Abstract:
:Acute phase proteins, synovial fluid (SF) cellular infiltrates, pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and Th1 (IL-2) and Th2 (IL-4) derived cytokine levels both in plasma and SF were examined in pauciarticular and polyarticular juvenile chronic arthritis (JCA) patients during the active (n = 22) and inactive (n = 14) period in order to determine pathogenic mechanisms and correlations between cytokines and laboratory parameters showing disease activity. The erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP) and IgG concentrations were found to be significantly elevated in the active period of JCA. In pauciarticular JCA patients, when compared with their peripheral blood lymphocyte subpopulations, SF CD3+ cells (73.1%) and HLA-DR+ active T cells (22.5%) were found to be significantly increased. In the active period of JCA, plasma TNF-alpha and IL-6 concentrations were significantly elevated. Plasma IL-2 and IL-4 levels were not elevated and were found to be similar to those in the inactive phase and in healthy controls. SF IL-6, TNF-alpha and IL-1alpha levels were extremely high in all the patients. SF IL-4 and IL-2 levels were all undetectable. There was a significant correlation between ESR values and plasma IL-6 levels and between serum CRP levels and plasma IL-6 and TNF-alpha concentrations. In conclusion, increased local production of pro-inflammatory cytokines appears to account for the articular manifestations of JCA. The impaired production of anti-inflammatory Th2-derived cytokines (IL-4) seems to cause increased production of inflammatory cytokines acting on the balance between them. The deficit in IL-2 production was not suggested to be primarily involved in the pathogenesis. In addition, not only CRP and ESR values, but also plasma IL-6 and TNF-alpha concentrations may be used as markers of disease activity.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Kutukculer N,Caglayan S,Aydogdu Fdoi
10.1007/BF01451007subject
Has Abstractpub_date
1998-01-01 00:00:00pages
288-92issue
4eissn
0770-3198issn
1434-9949journal_volume
17pub_type
杂志文章abstract::Streptococcus is well associated with a myriad of inflammatory diseases. Among others, this bacterium is linked to the triggering of psoriasis and to post-streptococcal reactive arthritis (PSRA), an arthritis which is typically confined to peripheral joints. Three patients who developed acute psoriatic spondyloarthrit...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-019-04695-y
更新日期:2019-09-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3282-1
更新日期:2016-11-01 00:00:00
abstract::Takayasu arteritis (TA) is a chronic inflammatory disease. Interleukin (IL)-6 and IL-10 are important cytokines involved in the immune response of TA in some ethnicities. We investigated whether the single-nucleotide polymorphism (SNP) of IL-6 and IL-10 genes and their expressions were associated with TA in a Chinese ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4260-6
更新日期:2019-01-01 00:00:00
abstract::Juvenile idiopathic arthritis (JIA) has rarely been reported among Black Africans. This retrospective case study was part of an audit of cases presenting to a private practice rheumatology clinic in Lagos, Nigeria. The objective of this study was to determine the clinical, laboratory, and radiographic features of pati...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1401-y
更新日期:2010-07-01 00:00:00
abstract::The aim of this study was to investigate generalized osteoarthritis (GOA) by combining X-ray grading of the knee, spine and hand using biochemical markers for arthritis, such as YKL-40 and urinary pyridinoline (Pyr). One hundred and thirty postmenopausal women with primary knee osteoarthritis (OA) aged 55-92 years wer...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0802-6
更新日期:2003-12-01 00:00:00
abstract::The aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2540-3
更新日期:2014-05-01 00:00:00
abstract::A 62-year-old man who suffered from severe deforming arthritis, secondary to chronic tophaceous gout with multilobular, solid, tender, enlarged subcutaneous nodules, and draining tophi in right second finger, was treated by free flap and finally got the more functional and aesthetic result. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1321-x
更新日期:2010-03-01 00:00:00
abstract::We report an adult case of reflex sympathetic dystrophy. In contrast to the usual findings in adults, three phase bone scintigraphy showed decreased bloodflow and bloodpool with hypofixation on delayed steady state bone scan of the affected lower limb. In spite of various therapeutic attempts severe dystrophy develope...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208035
更新日期:1991-03-01 00:00:00
abstract::We report the case of a 45-year-old Caucasian woman suffering from ankylosing spondylitis and undifferentiated connective tissue disease in whom the prevailing clinical features were retinal vasculitis and inflammatory low back pain. HLA typing revealed the concomitant presence of B27 and DR2 antigens. We hypothesise ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01451055
更新日期:1998-01-01 00:00:00
abstract::To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patient...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208026
更新日期:1991-03-01 00:00:00
abstract::Acute gouty arthritis (AGA) is an auto-inflammatory disease characterized by resolving spontaneously, which suggests that negative feedback loops control inflammatory and immunological responses to monosodium urate (MSU) crystals. By now, the molecular mechanism for spontaneous resolution of acute GA remains unclear; ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3109-5
更新日期:2016-09-01 00:00:00
abstract::A 78-year-old Japanese woman with Sjögren's syndrome complicating immune-mediated aplastic anaemia is described. A diagnosis of aplastic anaemia was made from severe pancytopenia with hypoplastic marrow. Laboratory studies suggested an association of bone marrow suppressive T-lymphocytes with the pathogenesis of aplas...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231538
更新日期:1993-06-01 00:00:00
abstract::The aim of this study is to compare effectiveness and safety of Infliximab (INF), Etanercept (ETN), and Adalimumab (ADA) in patients with psoriatic arthritis (PsA) with inadequate response to a previous disease-modifying antirheumatic drug (DMARD). One hundred consecutive PsA patients with inadequate response to a pre...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-009-1340-7
更新日期:2010-04-01 00:00:00
abstract::The "A disintegrin and metalloprotease" (ADAM) family is thought to play an important role in tissue destruction and inflammatory reactions. ADAM-17 was first described as the protease responsible for tumor necrosis factor (TNF)-α shedding. Here, we have shown the expression of ADAM-17 in inflammatory myopathy and dem...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4014-5
更新日期:2018-04-01 00:00:00
abstract::Little data exists from the developing world on pregnancy in systemic lupus erythematosus (SLE). A 10-year review of pregnancies in lupus patients was conducted at a tertiary hospital in a developing country. Forty-seven pregnancies in 31 patients were identified. Eleven (23%) booked after 20 weeks gestation. There we...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0749-0
更新日期:2008-05-01 00:00:00
abstract::A 65-year-old woman presented with vertebral fractures of the lumbar spine and a history of pathological fractures following minor trauma, which had occurred before the onset of menopause. Her past medical history was significant for intermittent low back pain since childhood, which was attributed to thoracolumbar sco...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050052
更新日期:1999-01-01 00:00:00
abstract::The level of the N terminal fragment of procollagen III (P3NP) levels of 100 consecutive patients affected by rheumatoid arthritis (RA) were evaluated in comparison with disease activity markers (erythrocytes sedimentation rate, C reactive protein), immunological status (rheumatoid factors, immune complexes) and joint...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02283106
更新日期:1992-12-01 00:00:00
abstract::Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1405-7
更新日期:2010-09-01 00:00:00
abstract::A 63-year-old man with hypertrophic pachymeningitis (HP) and an undifferentiated connective tissue disease is described. Combined therapy with prednisolone and azathioprine improved his symptoms. The association between an undifferentiated connective tissue disease and HP is discussed. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0018-z
更新日期:2006-05-01 00:00:00
abstract::While fibromyalgia is frequently associated with ear-related symptoms such as feeling of ear fullness, earache, and tinnitus, the pathogenesis of these ear-related symptoms in fibromyalgia patients is unknown. Here, we focused on clarifying the pathogenesis of ear fullness, a particularly common symptom observed in fi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2287-2
更新日期:2013-10-01 00:00:00
abstract::We report two cases of a full-thickness rotator cuff tear followed by acromioclavicular cyst formation in patients with longstanding erosive polyarticular rheumatoid arthritis. One of the consequences of a rotator cuff tear is articular instability with upward migration of the humeral head. The ensuing chronic frictio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01452269
更新日期:1998-01-01 00:00:00
abstract::Articular involvement is described in a 58-year-old female patient with scleroderma. Radiological findings included intra-articular calcification, destructive osteoarthritis and selective involvement of the first metacarpal base. The discussion attempts to explain the way in which intra-articular calcification and ost...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032338
更新日期:1984-09-01 00:00:00
abstract::We investigated the occurrence of an active cytomegalovirus (CMV) infection in patients with polyarteritis nodosa (PAN). Eleven patients with PAN were screened for the presence of CMV-DNA in their blood using the polymerase chain reaction (PCR). Serum anti-CMV IgG and anti-CMV IgM antibodies were determined by enzyme-...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050148
更新日期:1999-01-01 00:00:00
abstract::A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0037-9
更新日期:2006-07-01 00:00:00
abstract::This study aims to explore patient's concerns when discussing sexual problems caused by chronic low back pain with their healthcare provider. It also aims to identify factors influencing and limiting such communication. A cross-sectional analysis of 100 consenting chronic low back pain sexually active patients was car...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2299-y
更新日期:2013-10-01 00:00:00
abstract::The objective of this study is to identify baseline factors associated with rheumatoid arthritis (RA) diagnosis at the end of 1-year follow-up in a cohort of patients with very recent onset arthritis. Incident cases with self-reported arthritis ( journal_title:Clinical rheumatology pub_type: 杂志文章 doi:10.1007/s10067-009-1206-z 更新日期:2009-10-01 00:00:00
abstract::We describe two cases of rheumatoid arthritis (RA) patients and concomitant hepatitis C virus infection (HCV), treated with cyclosporine A (CsA) and anti-TNF-alpha agents. SGOT/SGPT and HCV-RNA serum levels remained unchanged longer than 1 year of treatment. No side effects were registered. We suggest that combination...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0412-1
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:Our aim was to investigate the prevalence value of a high-avidity antinuclear antibody (ANA) of the IgG isotype (HA IgG ANA) compared with that of ANAs of other isotypes in patients with systemic lupus erythematosus (SLE) and to assess the associations of HA IgG ANA with the activity of SLE and lupus nephrit...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05040-4
更新日期:2020-09-01 00:00:00
abstract::The aim of this study was to ascertain whether fibromyalgia patients with positive ANA develop other features of connective tissue disease over 2-4 years' follow-up. Patients attending our clinic with a diagnosis of fibromyalgia were identified. All ANA-positive patients (n = 12) were recruited and matched for age and...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200118
更新日期:2002-11-01 00:00:00
abstract::A correlation study was performed on the degree of muscle weakness in 36 patients with dermatomyositis and 69 with polymyositis in relation to muscle biopsy findings, electromyography (EMG) abnormalities, and serum concentrations of creatine kinase (CK), aspartate aminotransferase (AST) and alanine aminotransferase (A...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030515
更新日期:1990-12-01 00:00:00