Polyarteritis nodosa and cytomegalovirus: diagnosis by polymerase chain reaction.

Abstract:

:We investigated the occurrence of an active cytomegalovirus (CMV) infection in patients with polyarteritis nodosa (PAN). Eleven patients with PAN were screened for the presence of CMV-DNA in their blood using the polymerase chain reaction (PCR). Serum anti-CMV IgG and anti-CMV IgM antibodies were determined by enzyme-linked immunosorbent assays (ELISA). The ELISA for IgM was negative in all cases whereas that for IgG was positive in eight cases. Only one patient was positive for CMV-DNA by PCR. He presented with myalgia, polyarthralgia, fever and weight loss, suggesting PAN activity. CMV infection was uncommon in our series of patients with PAN, despite disease activity and immunosuppressor therapy. The finding of a transient CMV infection in one case at the beginning of PAN activity suggests that CMV may be involved in the pathogenesis of PAN.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Fernandes SR,Bértolo MB,Rossi CL,Samara AM,Bonon SH,Durante P,Costa SC

doi

10.1007/s100670050148

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

501-3

issue

6

eissn

0770-3198

issn

1434-9949

journal_volume

18

pub_type

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