Better effect of methotrexate on C-reactive protein during daily compared to weekly treatment in rheumatoid arthritis.

Abstract:

:Treatment with methotrexate (MTX) is well established in rheumatoid arthritis (RA), but dosing remains arbitrary as studies on the effect of different dosing schedules are lacking. In a randomised crossover design of 20 patients with RA, the effect of low (2.5mg) oral daily doses of MTX (15 mg weekly) was compared to intermittent weekly dosing (15 mg). C-reactive protein (CRP) values were lower and more stable on daily dosing compared to the significant (p < 0.05) changes in CRP observed during treatment with the same weekly dose. It may be postulated that nonresponders or patients with dose-dependent side effects may have clinical advantage from daily MTX dosing if hepatotoxicity and other side effects are not increased.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Seideman P

doi

10.1007/BF02231528

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

210-3

issue

2

eissn

0770-3198

issn

1434-9949

journal_volume

12

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:1997-06-01 00:00:00

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