Abstract：
:In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's phenomenon (RP) and healthy controls. Forty SSc patients, 18 primary RP cases, and 20 healthy controls were included in our study. The demographic and clinical features of patients with SSc were recorded. The serum levels of vascular endothelial growth factor (VEGF), vascular endothelial (VE)-cadherin, interleukin (IL)-20, IL-22, and IL-23 were assessed. In the SSc group, IL-20 level was significantly lower than in both primary RP group and controls (p values <0.001). VE-cadherin level in SSc was significantly higher than in primary RP (p = 0.016). The IL-22 and IL-23 and VEGF levels of SSc, primary RP, and control groups were similar (p values >0.05). In SSc patients, IL-23 correlated negatively with VEGF (r = -0.36, p = 0.025) and positively with VE-cadherin (r = 0.55, p < 0.001). IL-20 levels in SSc patients correlated with disease duration (r = 0.32, p = 0.044). SSc patients with limited involvement had significantly higher VE-cadherin levels than SSc patients with diffuse involvement (p = 0.044). We observed that IL-20 which is an IL-10 group angiogenesis indicator was observed to be suppressed in SSc, suggesting abnormal angiogenesis.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Aydoğdu E,Pamuk ÖN,Dönmez S,Pamuk GEdoi
10.1007/s10067-013-2317-0subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1599-603issue
11eissn
0770-3198issn
1434-9949journal_volume
32pub_type
杂志文章abstract：:The aim of this study is to describe the clinical features of Lebanese patients with Behçet's disease (BD) followed up at a tertiary care center in Lebanon. A retrospective review of medical records of 90 patients who fulfilled the International Study Group (ISG) criteria for diagnosis was performed. The clinical char...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0058-4
更新日期：2006-05-01 00:00:00
abstract：:Seventy-nine patients suffering from rheumatoid factor positive rheumatoid arthritis (RA) were included in this study. In each patient disease activity was assessed three times at two-week intervals during a four-week period. All factors that might possibly influence RA, except atmospheric conditions (AC) were held co...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02206665
更新日期：1991-12-01 00:00:00
abstract：:Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB inf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-1938-z
更新日期：2012-05-01 00:00:00
abstract：:We aimed to investigate the possible effects of thioredoxin 1 (Trx1) on the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and elucidate the possible mechanisms involved. We investigated the distribution and expression of Trx1 in synovial tissues from RA and osteoarthritis (...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3832-1
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Visfatin is an adipokine and has a crucial role in pro-inflammatory response. The aim of this study was investigating the visfatin levels of gingival crevicular fluid (GCF) in patients with systemic lupus erythematosus (SLE) and chronic periodontitis and healthy subjects. MATERIALS AND METHODS:Sixty non-obe...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04708-w
更新日期：2019-11-01 00:00:00
abstract：:Initial treatment of trapeziometacarpal osteoarthritis (TMO) often consists of intra-articular injection of corticosteroids or hyaluronic acid. Several studies have shown that ultrasound (US)-guided injections demonstrate greater precision and effectiveness when compared to blind techniques. The aim of our study was t...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1730-5
更新日期：2011-09-01 00:00:00
abstract：:A white female patient developed overlapping features of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) with severe pulmonary compromise. She was treated with steroids and azathioprine, which improved her clinical condition and spirometric status. In May 2002 she presented with continuous pain in her ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-1048-7
更新日期：2005-08-01 00:00:00
abstract：:The aim of this study was to investigate the association between the polymorphism of transporters associated with antigen processing ( TAP1/TAP2) genes and rheumatoid arthritis in Chinese patients. A total of 100 RA patients and 99 healthy control subjects were enrolled. Analyses with polymerase chain reaction (PCR) b...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0769-3
更新日期：2004-02-01 00:00:00
abstract：UNLABELLED:It has been suggested that in some patients non-traumatic aseptic osteonecrosis of the hip (AOH) could be the result of the intra-osseous thrombosis. Antiphospholipid antibodies (APL) have been associated with venous and arterial occlusive events and the association between AOH and APL syndrome has been repo...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02242453
更新日期：1997-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3530-4
更新日期：2017-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2847-0
更新日期：2015-03-01 00:00:00
abstract：:In the study of pathophysiological mechanisms in growth abnormalities of the juvenile knee in arthritis an animal model in dogs was developed. Arthritis was induced by intra-articular injections of Carrageenan. Prominent growth changes were enlargement of the distal femoral epiphysis, patellar squaring and decreased e...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02030752
更新日期：1984-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-1067-4
更新日期：2005-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02231528
更新日期：1993-06-01 00:00:00
abstract：:The aim of this study was to determine the emotional and sociodemographic characteristics of patients with ankylosing spondylitis (AS) and to investigate the impact of the disease on their social life and quality of life (QOL). This study included 101 patients with the diagnosis of AS. All patients filled in a questio...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-1150-5
更新日期：2006-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02201003
更新日期：1987-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-002-8277-4
更新日期：2002-05-01 00:00:00
abstract：:A case of polymyositis associated with scleroderma, adult coeliac disease, diabetes mellitus and IgA nephropathy is reported in a 33-year-old male. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031278
更新日期：1984-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1333-6
更新日期：2010-03-01 00:00:00
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journal_title：Clinical rheumatology
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF02283106
更新日期：1992-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-017-3760-0
更新日期：2018-08-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02208694
更新日期：1991-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-010-1530-3
更新日期：2010-10-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04665-4
更新日期：2019-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0802-6
更新日期：2003-12-01 00:00:00
abstract：INTRODUCTION/OBJECTIVES:Cardiovascular risk management of patients with systemic lupus erythematosus (SLE) is medically relevant. The objectives were to estimate the cardiovascular risk by different strategies in patients with SLE, analyzing which proportion of patients would be candidates to receive statin therapy, an...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04856-z
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION/OBJECTIVES:We hypothesized that mechanical compression of the knee in rheumatoid arthritis (RA) would mobilize occult extractable fluid and improve arthrocentesis success. METHODS:Sixty-seven consecutive knees with RA and 186 knees with OA and were included. Conventional arthrocentesis was performed and s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04524-2
更新日期：2019-08-01 00:00:00
abstract：:The original version of this article was revised due to a retrospective Open Access order. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10067-020-05278-y
更新日期：2020-10-01 00:00:00
abstract：:The aim of the study was to describe the long-term toxicity of antirheumatic and anti-inflammatory drugs in a paediatric rheumatology clinic population. One hundred and seventeen children were studied on first admission to a paediatric rheumatology clinic and after a mean of 8.6 +/- 0.4 years of follow-up. Medical rec...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01451288
更新日期：1998-01-01 00:00:00
