Abstract：
:Our aim was to determine reasons for admission, the prevalence and spectrum of infections, and the outcomes in a multiethnic cohort of hospitalized systemic lupus erythematosus (SLE) patients in Durban, South Africa. We reviewed the records of hospitalized SLE patients seen over a 79-month period; the demographic data, clinical manifestations, laboratory findings, reasons for admission, nature of infection, and outcome were recorded. Our 167 patients, comprising 59.3% Indians, 33.5% African Blacks, 5.4% Coloreds, and 1.8% Whites, had 327 admissions. Active disease and infections accounted for 218 (66.7%) and 115 (35.2%) admissions respectively, with 58 (17.7%) due to both active disease and infection. Features of active disease were mucocutaneous 33.0%, hematological 30.3%, renal 28.9%, and vasculitis 27.1%. Overall, 83 patients (49.7%) had 155 infections; pneumonia (36.8%), cutaneous sepsis (18.1%), tuberculosis (13.5%), urinary tract infections (12.9%), and septicemia (7.1%) were the most common. The organisms commonly isolated were Staphylococcus aureus 25.4%, Escherichia coli 20.3%, and Klebsiella species and Mycobacterium tuberculosis in 13.6% each. Serositis (odds ratio (OR) = 2.7, p = 0.005) and seizures (OR = 4.8, p = 0.007) were associated with increased risk of infection. Twenty-four (14.4%) patients died from infection and active disease; the patients who died had higher SLEDAI scores (p = 0.02) and longer duration of hospitalization (p = 0.03) but no significant associations on multiple logistic regression analysis. Bacterial infections, including tuberculosis, are common in SLE, and they are a major cause of mortality.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Dubula T,Mody GMdoi
10.1007/s10067-014-2847-0subject
Has Abstractpub_date
2015-03-01 00:00:00pages
479-88issue
3eissn
0770-3198issn
1434-9949journal_volume
34pub_type
杂志文章abstract：OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04802-z
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. METHODS:A total of 497 AAV patients were retrosp...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-04975-y
更新日期：2020-07-01 00:00:00
abstract：:Sarcoidosis is a multisystemic disease with cutaneous lesions present in about one fourth of patients. Cutaneous lesions may be specific or nonspecific based on the presence or the absence of sarcoidal granulomas. Subcutaneos sarcoidosis is the less frequent of the specific cutaneous lesions of sarcoidosis. We report ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-011-1731-4
更新日期：2011-08-01 00:00:00
abstract：:Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement mol...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-008-0838-8
更新日期：2008-04-01 00:00:00
abstract：:The aim of this research was to determine any correlations between Dickkopf-1 serum levels (Dkk-1, a natural inhibitor of the Wnt signaling pathway promoting osteoclastogenesis) and the Trabecular Bone Score (TBS), in systemic sclerosis (SSc) and rheumatoid arthritis (RA) patients. It also aimed at determining any dif...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4322-9
更新日期：2018-11-01 00:00:00
abstract：:We describe a 24-year old Caucasian man with gangrene of small bowels and intestinal resection due to mesenteric inflammatory veno-occlusive disease (MIVOD) who later developed deep vein thrombosis in his left leg. He had no clinical evidence of an underlying symptomatic connective tissue disease or Behçet's disease. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02230344
更新日期：1996-03-01 00:00:00
abstract：:Kidney involvement in immuno-mediated diseases is a life threatening complication to be early detected. Glomerulo-tubular functional indices, kidney-released enzymes and metabolic profiles were assessed in 21 patients with systemic lupus erythematosus, progressive systemic sclerosis and mixed cryoglobulinaemia, withou...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231679
更新日期：1996-01-01 00:00:00
abstract：:Autonomic nervous system (ANS) involvement has been studied in systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, Sjogren's syndrome, and ankylosing spondylitis but still has not been studied in psoriatic arthritis (PsA). The aim of this study was to investigate the prevalence and the nature of au...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2239-x
更新日期：2013-07-01 00:00:00
abstract：:We describe the case of a 26-year-old African female who was treated successfully with belimumab in a case of severe membranous lupus nephritis and retinal vasculitis, resistant to first line therapy. She presented initially with chronic dacryoadenitis and screening showed nephrotic-range proteinuria. Biopsy of the ki...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3153-1
更新日期：2016-06-01 00:00:00
abstract：:Pulse prednisolone hemisuccinate therapy (500 mg given intravenously on three occasions over two weeks) has been combined with either intramuscular sodium aurothiomalate or azathioprine in an assessment of 30 patients with rheumatoid arthritis. Significant improvement in a variety of clinical and biochemical assessmen...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02204452
更新日期：1988-06-01 00:00:00
abstract：:We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine sampl...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0632-z
更新日期：2007-12-01 00:00:00
abstract：:Statin-induced necrotising autoimmune myopathy (NAM) is a rare but disabling complication of statin therapy. Data regarding treatment and outcomes in these patients is sparse. We retrospectively identified those patients with a diagnosis of statin-induced NAM who were managed in a single-tertiary referral centre from ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3831-2
更新日期：2018-02-01 00:00:00
abstract：:To explore whether femoral cartilage thickness is related (and changes) with muscle strength in subjects with knee osteoarthritis (OA). Forty patients (27 F, 13 M) with knee OA-who were under quadriceps muscle strengthening program-were enrolled in the study. Isokinetic/isometric knee muscle strength measurements (at ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3271-4
更新日期：2016-08-01 00:00:00
abstract：:The aim of this study was to determine the serum interleukin-18 (IL-18) levels in patients with systemic lupus erythematosus (SLE) and to assess their relationship with disease activity. Thirty-five patients with SLE and 35 age- and sex-matched controls were enrolled in this study. Paired serum samples were collected ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-0867-x
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To assess whether systemic sclerosis (SSc) is associated with total knee arthroplasty (TKA) outcomes. METHODS:We used the 1998-2014 US National Inpatient Sample. We conducted multivariable-adjusted logistic regression analyses to examine the association of a diagnosis of SSc with post-TKA in-hospital complic...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04754-4
更新日期：2020-01-01 00:00:00
abstract：:Identification of patients with exposure to viral hepatitis is an important part of the care of patients with inflammatory arthritis. This study was conducted to assess the extent of hepatitis B and C screening, and the prevalence of viral hepatitis in a cohort of patients with established rheumatoid arthritis (RA). T...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2612-4
更新日期：2014-12-01 00:00:00
abstract：:Articular involvement is described in a 58-year-old female patient with scleroderma. Radiological findings included intra-articular calcification, destructive osteoarthritis and selective involvement of the first metacarpal base. The discussion attempts to explain the way in which intra-articular calcification and ost...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02032338
更新日期：1984-09-01 00:00:00
abstract：:We describe two cases of rheumatoid arthritis (RA) patients and concomitant hepatitis C virus infection (HCV), treated with cyclosporine A (CsA) and anti-TNF-alpha agents. SGOT/SGPT and HCV-RNA serum levels remained unchanged longer than 1 year of treatment. No side effects were registered. We suggest that combination...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0412-1
更新日期：2007-07-01 00:00:00
abstract：:In the early stage of the COVID-19 pandemic, Belgian health authorities endorsed the interim guidelines for the treatment of COVID-19 pneumonia: hydroxychloroquine (HCQ) recommended for treatment of hospitalized patients with moderate to severe disease. As a growing number of patients were admitted, inevitably, our in...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-020-05572-9
更新日期：2021-01-15 00:00:00
abstract：OBJECTIVES:The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM). METHODS:Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2,...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04503-7
更新日期：2019-08-01 00:00:00
abstract：:Up to now, there is no uniformly accepted treatment for avascular necrosis (AN) that alleviates pain and retards its progression. The aim of clinical and surgical treatments is usually only to improve blood support in the avascular area. The objective of the present study was to make a systematic review of the use of ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-008-0861-9
更新日期：2008-06-01 00:00:00
abstract：:In this scoping review, we sought to summarize the types of outcomes collected in pregnant patients with ankylosing spondylitis (AS), and to identify some methodological limitations related to pregnancy research in these patients. A comprehensive search was done to identify relevant articles in MEDLINE and Embase. We ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-021-05588-9
更新日期：2021-01-19 00:00:00
abstract：:The antichromatin antibody (aCT) has been described as a useful marker for lupus nephropathy. The relevance of its nephritogenic potential may be appropriately evaluated in the context of renal histopathology. Therefore, the present study investigated the relationship of aCT with a particular histopathologic class of ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0939-4
更新日期：2008-11-01 00:00:00
abstract：:Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-010-1405-7
更新日期：2010-09-01 00:00:00
abstract：:Septic sacroiliitis in childhood is a relatively rare condition. We describe a case of septic sacroiliitis occurring in an 11-year-old girl in whom the diagnosis was suspected on clinical findings and bone scan. Immunoscintigraphy with 99mTc-labelled antigranulocyte antibodies further supported the hypothesis for a se...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231689
更新日期：1996-01-01 00:00:00
abstract：:Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and e...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3563-3
更新日期：2017-04-01 00:00:00
abstract：:Anti-CCP (cyclic citrullinated peptide) is considered the most useful laboratory tool in the diagnosis of rheumatoid arthritis (RA). Some authors have also found this autoantibody in patients with scleroderma (SSc). The study aimed to investigate the prevalence of anti-CCP antibodies in SSc patients from Southern Braz...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1930-z
更新日期：2012-05-01 00:00:00
abstract：:In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of met...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02208347
更新日期：1995-05-01 00:00:00
abstract：:Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH analogs are extensively used in in vitro fertilization and treatment of sex hormone-dependent cancers due to their ability to bring about 'chemical castration'. Recently it has been showed that it also plays an important role in the m...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1426-2
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS:In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Dem...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05094-4
更新日期：2020-12-01 00:00:00
