Abstract:
:In this scoping review, we sought to summarize the types of outcomes collected in pregnant patients with ankylosing spondylitis (AS), and to identify some methodological limitations related to pregnancy research in these patients. A comprehensive search was done to identify relevant articles in MEDLINE and Embase. We included 21 studies assessing pregnancy outcomes in AS. Most studies reported disease flare during pregnancy, and few reported improved disease activity or stable disease. Disease flare occurred in 25-80% of patients during pregnancy and in 30-100% during the postpartum. There was no increased risk of pre-eclampsia across all studies. Based on two case-control studies, there was an increased risk for prematurity and small for gestational age in AS pregnancies, pooled odds ratio (95% confidence interval) 1.99 (1.30-3.05) and 2.41 (1.22-4.77), respectively. The etiologies of cesarean section were not related to joint issues from AS but were related to other causes like pre-eclampsia and prematurity. Some key methodological issues were related to the study design, selection of study participants, disease classification, choice of control participants, and outcome measures. Based on the current literature review, some key areas for future research should evaluate the disease state at conception, effects of pharmacological treatment for AS during pregnancy, and long-term outcomes of children born to women with AS. The use of pregnancy registers and validated measurement tools in pregnancy will help to improve the state and quality of evidence in this field. Key Points • Disease flare during pregnancy in patients with ankylosing spondylitis (AS) occurred in 25-80% of the cases in the various studies, and in 30-100% of the cases during the postpartum period. • There was an increased risk for prematurity, and no increased risk of pre-eclampsia or small for gestational age. Etiologies of cesarean section were not related to the hip or sacroiliac joint affection of the disease but to other causes like pre-eclampsia and prematurity. • This study provides a comprehensive overview of issues related to research on pregnant women with ankylosing spondylitis (AS). We addressed methodological issues related to the study design, selection of study participants, disease classification, control choice, assessment of outcomes measures, and statistical analysis. • The use of pregnancy registers and validated disease activity measurement tools for pregnancy can enhance pregnancy research in women with AS.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Mokbel A,Lawson DO,Farrokhyar Fdoi
10.1007/s10067-021-05588-9subject
Has Abstractpub_date
2021-01-19 00:00:00eissn
0770-3198issn
1434-9949pii
10.1007/s10067-021-05588-9pub_type
杂志文章,评审abstract::IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...
journal_title:Clinical rheumatology
pub_type: 杂志文章
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doi:10.1007/s100670070034
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pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05234-w
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pub_type: 杂志文章
doi:10.1007/s10067-014-2525-2
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doi:10.1007/s10067-017-3868-2
更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-017-3831-2
更新日期:2018-02-01 00:00:00
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更新日期:2013-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF02229644
更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF02042773
更新日期:1982-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-017-3928-7
更新日期:2018-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231583
更新日期:1993-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231567
更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s100670200029
更新日期:2002-02-01 00:00:00
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pub_type: 信件
doi:10.1007/s10067-004-0922-7
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:This case-control study aimed to analyze the clinical features and determine the expression of type I interferon-induced genes in systemic lupus erythematosus (SLE) patients harboring the CD11b rs1143679 single-nucleotide polymorphism (SNP) and elucidate whether it is involved in the relapses of SLE. METHODS...
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pub_type: 杂志文章
doi:10.1007/s10067-020-05330-x
更新日期:2020-08-12 00:00:00
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pub_type: 杂志文章
doi:10.1007/pl00011216
更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-005-1150-5
更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-020-05132-1
更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-014-2642-y
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1007/s100670200016
更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-016-3207-z
更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00