Abstract:
:We reviewed studies concerning immunomodulating therapy in systemic sclerosis. These comprise mostly uncontrolled trials and case reports. Some of these studies hint at a possible beneficial effect of antimetabolites (azathioprine, 5-fluoro-uracil and methotrexate), cyclosporine and interferon-gamma. However, to give a clearcut answer on the efficacy of these drugs in systemic sclerosis, controlled studies are urgently needed.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
van den Hoogen FH,Boerbooms AM,van de Putte LBdoi
10.1007/BF02114391subject
Has Abstractpub_date
1990-09-01 00:00:00pages
319-24issue
3eissn
0770-3198issn
1434-9949journal_volume
9pub_type
杂志文章,评审abstract::The current treatment for antiphospholipid syndrome (APS) with thrombotic manifestation is long-term anticoagulation. Vitamin K antagonists (VKA) are usually the agents of choice. However, VKA limitations, such as unpredictable anticoagulation effects due to interaction with diet and other drugs, require regular monit...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3030-y
更新日期:2016-03-01 00:00:00
abstract::Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02229707
更新日期:1996-05-01 00:00:00
abstract::Diffuse systemic sclerosis and the related syndromes were diagnosed in 115 patients during 1977-1987. Sixty-nine patients were available for clinical evaluation and analysis. These included 46 patients with diffuse systemic sclerosis, 2 with limited cutaneous systemic sclerosis, 2 with linear scleroderma, 18 with over...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207649
更新日期:1991-06-01 00:00:00
abstract::The aim of this study was to investigate the association between the polymorphism of transporters associated with antigen processing ( TAP1/TAP2) genes and rheumatoid arthritis in Chinese patients. A total of 100 RA patients and 99 healthy control subjects were enrolled. Analyses with polymerase chain reaction (PCR) b...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0769-3
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal tract, and kidney involvement. Microribonucleic acids (miRNAs) are 18-25 base-long non-coding RNA group acting on gene expression. They ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05441-5
更新日期:2020-10-10 00:00:00
abstract::We report a case of a 56-year-old woman with an alleged diagnosis of an acute coronary syndrome that was later correctly identified in our Cardiology Unit as antisynthetase syndrome (AS) with inflammatory cardiac involvement. In this case report, we focus on clinical features of this rare autoimmune disease aiming to ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-019-04527-z
更新日期:2019-08-01 00:00:00
abstract::A 71-year-old male rheumatoid patient presented with MRSA septic arthritis. The impact of this organism on musculoskeletal practice is discussed. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01450904
更新日期:1998-01-01 00:00:00
abstract::Infection is a major cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). To describe the pattern of serious infections in patients with SLE and to identify the predictors of infection-related mortality among SLE patients with serious infections, we prospectively studied all SLE pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4102-6
更新日期:2018-08-01 00:00:00
abstract::Mycobacterium bovis Bacillus Calmette-Guérin (BCG) instillations are used in bladder cancer treatment. Adverse effects can occur. Osteoarticular complications are mainly reactive arthritis, but true infections have been described, such as vertebral osteomyelitis. We made a review of M. bovis BCG vertebral osteomyeliti...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-019-04500-w
更新日期:2019-06-01 00:00:00
abstract::Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1405-7
更新日期:2010-09-01 00:00:00
abstract::We reported a case of dermatomyositis (DM) with liver disturbance in a 50-year-old Japanese female. She presented with fever, muscle weakness, and typical DM rashes. On clinical and serological examinations, the liver impairment was initially diagnosed as probable autoimmune hepatitis, which was denied by a histologic...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1397-3
更新日期:2010-08-01 00:00:00
abstract::The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3698-2
更新日期:2018-03-01 00:00:00
abstract::Joint lavage for knee osteoarthritis is an invasive procedure that can be stressful and painful. We aimed to assess the impact of music therapy on perioperative anxiety, pain and tolerability of the procedure in patients undergoing joint lavage performed with two needles. We randomized all patients diagnosed with knee...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-011-1925-9
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:The association between hyperuricemia and insulin resistance (IR) has been demonstrated by many studies, but the traditional IR indexes are too impractical to be used in clinical practice for the recognition of the IR state in individuals with hyperuricemia. Therefore, we aimed to further investigate the asso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04671-6
更新日期:2019-11-01 00:00:00
abstract::The objective of this study was to understand the patient experience of musculoskeletal imaging tests for investigation of inflammatory arthritis and factors that contribute to this experience. We conducted a thematic analysis of semi-structured interviews with 33 patients who had a recent peripheral joint musculoskel...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3760-0
更新日期:2018-08-01 00:00:00
abstract::Hyperimmunoglobulinemia D syndrome (HIDS) is newly recognized and resembles familial Mediterranean fever (FMF). It is inherited as an autosomal recessive trait. Mutation of the gene coding for mevalonate kinase is responsible for the disease. The gene is located at chromosome 12q24. The patients initially described we...
journal_title:Clinical rheumatology
pub_type: 信件
doi:10.1007/s10067-004-0953-0
更新日期:2005-02-01 00:00:00
abstract::A 65-year-old woman presented with vertebral fractures of the lumbar spine and a history of pathological fractures following minor trauma, which had occurred before the onset of menopause. Her past medical history was significant for intermittent low back pain since childhood, which was attributed to thoracolumbar sco...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050052
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between disease activity and cognitive impairment in patients with rheumatoid arthritis (RA). METHODS:A total of 464 patients from the rheumatoid arthritis registry of two academic centers, Siriraj and Phramongkutklao hospitals, were included. Demographic, clinical, and laborat...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04488-3
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Our aim was to investigate the prevalence value of a high-avidity antinuclear antibody (ANA) of the IgG isotype (HA IgG ANA) compared with that of ANAs of other isotypes in patients with systemic lupus erythematosus (SLE) and to assess the associations of HA IgG ANA with the activity of SLE and lupus nephrit...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05040-4
更新日期:2020-09-01 00:00:00
abstract::The burden of anxiety in patients with systemic lupus erythematosus (SLE) compared to those with other inflammatory rheumatological conditions is unclear. We aimed to compare the frequency and level of anxiety between patients with SLE, rheumatoid arthritis (RA), and gout and healthy individuals and explore independen...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1651-8
更新日期:2011-06-01 00:00:00
abstract::This study aims to determine the prevalence and clinical significance of anti-CCP isotype IgA in a population of patients with primary Sjögren's syndrome (pSS). Sixty-two patients diagnosed according to the USA-European classification criteria for pSS were examined two to four times during a 60.4-month follow-up, and ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1675-0
更新日期:2011-03-01 00:00:00
abstract::The authors describe an atypical case of a patient having giant cell arteritis presenting only with fever, diagnosed by positron emission tomography and subsequently confirmed by temporal artery biopsy. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0831-7
更新日期:2008-06-01 00:00:00
abstract::This study aims to examine the needs and preferences regarding the delivery of health care services and information provision and their determinants in patients with systemic sclerosis (SSc). A questionnaire was sent to 77 SSc outpatients, comprising 27 items on health care needs within the domains physical, psycholog...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1645-6
更新日期:2011-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multi-system chronic inflammatory disease with a broad spectrum of clinical and serological manifestations. Although clinical evidence of proximal skeletal muscle involvement is not rare in patients with SLE, there is no knowledge about the effects of SLE on the macroscopic stru...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2249-8
更新日期:2013-08-01 00:00:00
abstract::In a great majority of patients with systemic lupus erythematosus (SLE) lymphocytotoxic antibodies (LCA) are detected. The reported prevalence depends on the methods of detection and definition of test-positivity. The pathogenetic role of LCA remains unclear. Different reports show that LCA can have an influence on mo...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02229861
更新日期:1994-03-01 00:00:00
abstract::Gastrointestinal tract (GIT) is the most common organ system involved in systemic sclerosis (SSc). GIT involvement is mainly attributed to GIT dismobility and wide mouth diverticular. GIT involvement in SSc can be also severely debilitating and even life threatening. To our knowledge, the presence of gastrointestinal ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0264-8
更新日期:2007-06-01 00:00:00
abstract::This study quantified the association between recreational physical activity and daily function in women with fibromyalgia, and determined if this association is mediated by symptoms of pain, depression, or body mass. Twenty-three women diagnosed with fibromyalgia participated in an observational survey study. Recreat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2386-0
更新日期:2015-01-01 00:00:00
abstract::The objectives of this study are to assess the risk of asymptomatic cranial neuropathy among patients with systemic lupus erythematosus (SLE) and find any association with disease activity and antiribosomal P antibodies. This study is a case-control study including 60 female patients and 30 healthy female controls. Di...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2679-y
更新日期:2014-01-01 00:00:00
abstract::Total body bone mineral (TBBM) measured by dual photon absorptiometry and local bone mineral (BMC) measured by single photon absorptiometry were determined in 55 patients with definite or classical rheumatoid arthritis. All of them had been on a steady dose of anti-inflammatory drugs for at least 12 months, and furthe...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041401
更新日期:1983-09-01 00:00:00
abstract::The objective of this study was to determine possible differences in the outcome of patients with rheumatoid arthritis (RA) with disease onset early and late in life. As part of a broader outcome study of RA which included patients seen in the division of Rheumatology of Hospital Universitario Marqués de Valdecilla of...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-1067-4
更新日期:2005-09-01 00:00:00