Abstract：
INTRODUCTION:Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal tract, and kidney involvement. Microribonucleic acids (miRNAs) are 18-25 base-long non-coding RNA group acting on gene expression. They have been shown to be effective on the immune system studies to date. METHOD:In our study, 24 IgAV children with skin and joint involvement and 24 healthy children were included. Five different miRNAs (miR-33, miR-34, miR-122, miR-204, and miR451) known to be expressed in plasma and related with autoimmunity pathogenesis were evaluated. miRNAs were compared between the active period of the disease, the post-treatment period, and the healthy group using the real-time PCR method. RESULTS:Expression levels of miRNA-33 and miRNA-34 increased significantly in active period of the patients compare with inactive period and control groups. The expression levels of miRNA-122 and miRNA-204 decreased significantly in active period of the patients compare with other two groups. There was no significant difference in miRNA-451 levels. CONCLUSIONS:With the experience we gained from our recent studies, we think that miRNA-204 may be a significant biomarker in autoimmune diseases. Our study is the first study between IgAV and miRNAs in children. More studies are needed to reveal this relationship. Key Points • This is the first paper to show the relationship between miRNAs and childhood IgAV. • It will provide a new perspective to evaluate the pathogenesis of the disease.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Cebi AH,Demir F,Ikbal M,Kalyoncu Mdoi
10.1007/s10067-020-05441-5subject
Has Abstractpub_date
2020-10-10 00:00:00eissn
0770-3198issn
1434-9949pii
10.1007/s10067-020-05441-5pub_type
杂志文章abstract：:Small synovial cysts are a common manifestation of juvenile idiopathic arthritis; large brachial cysts, however, are a rare sign of the disease and they must be differentiated from other soft tissue swelling which are not related to articular involvement. We describe the case of three children with juvenile idiopathic...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0860-x
更新日期：2008-12-01 00:00:00
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journal_title：Clinical rheumatology
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：1995-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF03342632
更新日期：1995-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-1009-7
更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-016-3347-1
更新日期：2016-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,已发布勘误
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更新日期：2019-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02032359
更新日期：1986-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1898-8
更新日期：2012-04-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02041395
更新日期：1983-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3608-7
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s100670050131
更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04462-z
更新日期：2019-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04733-9
更新日期：2019-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 历史文章,杂志文章
doi：10.1007/s10067-016-3493-5
更新日期：2017-01-01 00:00:00
