A comparison of diflunisal and phenylbutazone in the treatment of ankylosing spondylitis.

Abstract:

:A 12-week double-blind randomized drug trial followed by an open extension period of 36 weeks was carried out in 38 male patients with ankylosing spondylitis (AS) to compare the efficacy and safety of diflunisal (500 mg twice daily) and phenylbutazone (200 mg twice daily). Both drugs proved to be effective in improving the severity of symptoms associated with AS, and this improvement was maintained throughout the open extension period. Initially diflunisal had a more pronounced and rapid analgesic action, whereas phenylbutazone was more effective in increasing axial mobility. During the study 9 patients dropped out: 3 in each treatment group due to side effects and 1 in each group due to lack of efficacy; another patient was lost to follow-up. The two drugs were similarly safe as judged by the occurrence of adverse clinical effects, mainly gastrointestinal. This study again demonstrates the value of phenylbutazone in AS but, taking into account the possible haematological side effects, the use of other NSAIDs is stressed. Diflunisal is an alternative capable of improving the painful stiffness associated with AS.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Franssen MJ,Gribnau FW,van de Putte LB

doi

10.1007/BF02032359

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

210-20

issue

2

eissn

0770-3198

issn

1434-9949

journal_volume

5

pub_type

临床试验,杂志文章,随机对照试验
  • Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians.

    abstract::Chronic hepatitis C virus (HCV) viremia has been known to provoke a plethora of autoimmune syndromes referred to as extrahepatic manifestations of chronic HCV infection. Aim of the current study was to assess the prevalence of rheumatologic manifestations among Egyptians with hepatitis C infection and its' association...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1463-x

    authors: Mohammed RH,ElMakhzangy HI,Gamal A,Mekky F,El Kassas M,Mohammed N,Abdel Hamid M,Esmat G

    更新日期:2010-12-01 00:00:00

  • Paget's sarcoma--with two illustrative cases.

    abstract::Two cases of Paget's sarcoma of bone are described. The first one is mainly characterized by the almost simultaneous degeneration of the only two existing locations of the underlying Paget's disease. The second case is one of monostotic Paget's disease of the scapula disclosed by the malignant degeneration. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031268

    authors: Huaux JP,Esselinckx W,Noel H,Grodos J,Nagant de Deuxchaisnes C

    更新日期:1984-12-01 00:00:00

  • Primary biliary cirrhosis (PBC)-CREST overlap syndrome with coexistence of Sjögren's syndrome and thyroid dysfunction.

    abstract::Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia (CREST) syndrome, a limited form of systemic sclerosis, is sometimes complicated by primary biliary cirrhosis (PBC). A 52- and 61-year-old Japanese woman with PBC-CREST overlap syndrome accompanied by Sjögren's syndrome, and Hashi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0178-x

    authors: Nakamura T,Higashi S,Tomoda K,Tsukano M,Sugi K

    更新日期:2007-04-01 00:00:00

  • Fungal arthritis of the knee caused by Mycoleptodiscus indicus.

    abstract::Mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. It is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. This is the first report of septic arthritis with this fungus in a healthy Canadian male. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1448-9

    authors: Dewar CL,Sigler L

    更新日期:2010-09-01 00:00:00

  • Cough as the presenting symptom of large vessel vasculitis.

    abstract::We report the case of a 57-year-old woman presenting with persistent cough, weight loss, and fever. An extensive work-up revealed laboratory signs of inflammation and a mild thickening of the aortic wall on computed tomographic scan of the thorax. These findings raised the suspicion of large vessel vasculitis that was...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-004-1052-y

    authors: Van der Schueren B,Lambert M

    更新日期:2005-08-01 00:00:00

  • Prednisolone pharmacokinetics in patients with rheumatoid arthritis, polymyalgia rheumatica and asthma.

    abstract::The pharmacokinetic profile of a single 10 mg oral dose of prednisolone was studied in three groups of six patients with rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and bronchial asthma (BA) who were already receiving steroid therapy. A fourth group of age and sex-matched normal controls was also studied. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02054250

    authors: Taggart AJ,Astbury C,Dixon JS,Bird HA

    更新日期:1986-09-01 00:00:00

  • Causes of death in hospitalized patients with systemic lupus erythematosus: a 10-year multicenter nationwide Chinese cohort.

    abstract::To estimate the mortality and describe the causes of death in a large multicenter cohort of hospitalized patients with SLE in China. This was a retrospective study of a nationwide SLE cohort (10 centers, 29,510 hospitalized patients) from 2005 to 2014 in China. Standardized mortality ratios (SMRs) were calculated for ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10067-018-4259-z

    authors: Wu XY,Yang M,Xie YS,Xiao WG,Lin J,Zhou B,Guan X,Luo CN,Che N,Liu XZ,Wang C,Teng JL,Cheng XB,Ye JN,Su YT,Shi H,Yin YF,Liu MR,Sun Y,Hu QY,Zhou ZC,Chi HH,Liu Y,Zhang X,Chen JW,Zhang MJ,Zhao DB,Yang CD,

    更新日期:2019-01-01 00:00:00

  • Efficacy and safety profile of intravenous tocilizumab versus intravenous abatacept in treating female Saudi Arabian patients with active moderate-to-severe rheumatoid arthritis.

    abstract:OBJECTIVES:To compare the efficacy and safety of tocilizumab with those of abatacept in patients with active rheumatoid arthritis not responding to anti-tumor necrosis factor therapy. METHODS:A prospective, open-label study was carried out on adult females with moderate-to-severe rheumatoid arthritis. Patients were ra...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10067-019-04508-2

    authors: Elmedany SH,Mohamed AE,Galil SMA

    更新日期:2019-08-01 00:00:00

  • Coexistence of ankylosing spondylitis and undifferentiated connective tissue disease.

    abstract::We report the case of a 45-year-old Caucasian woman suffering from ankylosing spondylitis and undifferentiated connective tissue disease in whom the prevailing clinical features were retinal vasculitis and inflammatory low back pain. HLA typing revealed the concomitant presence of B27 and DR2 antigens. We hypothesise ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF01451055

    authors: Galluzzo E,Taglione E,Bartolomei MP,Pasero G,Riente L

    更新日期:1998-01-01 00:00:00

  • Unusual articular abnormalities in scleroderma.

    abstract::Articular involvement is described in a 58-year-old female patient with scleroderma. Radiological findings included intra-articular calcification, destructive osteoarthritis and selective involvement of the first metacarpal base. The discussion attempts to explain the way in which intra-articular calcification and ost...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02032338

    authors: Albert J,Ott H

    更新日期:1984-09-01 00:00:00

  • Thrombocytopenia and thrombosis: a double-edged sword.

    abstract::Severe thrombocytopenia with bleeding associated with a life-threatening thrombotic manifestation in the setting of antiphospholipid syndrome is a major diagnostic and therapeutic challenge for the clinician. Hemorrhage is a less common complication than thrombosis in patients with APS, although severe thrombocytopeni...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-013-2416-y

    authors: Nyo MT,Kalla AA

    更新日期:2014-04-01 00:00:00

  • A case of myeloperoxidase-antineutrophil cytoplasmic antibody positive-polyarteritis nodosa complicated by interstitial pneumonia and rapidly progressive renal failure.

    abstract::A 73-year-old woman was admitted to our hospital because of persistent high fever and cough, generalized myalgia, and renal dysfunction. Laboratory examination revealed severe inflammatory signs, pulmonary fibrosis, progression of renal impairment with active nephritic urinary sediments, and a high titer of myeloperox...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0142-9

    authors: Sugimoto T,Kanasaki K,Koyama T,Yokomaku Y,Yasuda H,Kashiwagi A,Koya D

    更新日期:2007-03-01 00:00:00

  • A systematic review of the effect of TNF-alpha antagonists on lipid profiles in patients with rheumatoid arthritis.

    abstract::Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-010-1405-7

    authors: Pollono EN,Lopez-Olivo MA,Lopez JA,Suarez-Almazor ME

    更新日期:2010-09-01 00:00:00

  • Effect of delayed diagnosis on disease course and management of Churg-Strauss syndrome: a retrospective study.

    abstract::Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2127-9

    authors: Sokołowska B,Szczeklik W,Mastalerz L,Kuczia P,Wodkowski M,Stodółkiewicz E,Macioł K,Musiał J

    更新日期:2013-03-01 00:00:00

  • Mean platelet volume as an indicator of disease activity in juvenile SLE.

    abstract::The aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2540-3

    authors: Yavuz S,Ece A

    更新日期:2014-05-01 00:00:00

  • Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.

    abstract::We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine sampl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0632-z

    authors: Otukesh H,Chalian M,Hoseini R,Chalian H,Hooman N,Bedayat A,Yazdi RS,Sabaghi S,Mahdavi S

    更新日期:2007-12-01 00:00:00

  • Impact of TNF-α inhibitor on lipid profile and atherogenic index of plasma in axial spondyloarthritis: 2-year follow-up data from the Catholic Axial Spondyloarthritis COhort (CASCO).

    abstract::To evaluate the influence of TNF-α inhibitor on lipid profile and atherogenic index of plasma (AIP) in axial spondyloarthritis (axSpA) patients with long-term use of stable dose TNF-α inhibitor. AxSpA patients were enrolled in the Catholic Axial Spondyloarthritis COhort (CASCO). We collected their data annually and an...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04767-z

    authors: Min HK,Lee J,Ju JH,Park SH,Kwok SK

    更新日期:2020-02-01 00:00:00

  • Antinuclear antibody testing: discordance between commercial laboratories.

    abstract::Antinuclear antibody (ANA) test results frequently affect the course of patients' evaluations, diagnosis, and treatment, but different laboratory centers may yield conflicting results. This study investigated the degree of agreement between laboratory results in a group of subjects who had ANA testing performed at two...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3241-x

    authors: Abeles AM,Gomez-Ramirez M,Abeles M,Honiden S

    更新日期:2016-07-01 00:00:00

  • PASE and EARP questionnaires for the identification of enthesitis, synovitis, and tenosynovitis in patients with psoriasis.

    abstract::The aim of this study was to assess the diagnostic value of the Psoriatic Arthritis Screening Evaluation (PASE) and Early Psoriatic Arthritis Screening Questionnaire (EARP) questionnaires in the ultrasonographic detection of enthesitis, synovitis, and tenosynovitis. A cross-sectional study was done in a total of 96 co...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3392-9

    authors: Vidal D,Reina D,Martin JL,Cerdà D,Estrada P,García-Diaz S,Navarro V,Peramiquel L,Roig D,Torrente V,Corominas H

    更新日期:2016-10-01 00:00:00

  • Arterial occlusion causing large bowel infarction--a reflection of clotting diathesis in SLE.

    abstract::The patient, a 44-year old woman with systemic lupus erythematosus, (SLE), developed infarction of the bowel and spleen after occlusion of the inferior mesenteric and splenic arteries, necessitating colectomy and splenectomy. She had had previous cerebral thromboses and a lower limb deep vein thrombosis. Histological ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02030977

    authors: Asherson RA,Morgan SH,Harris EN,Gharavi AE,Krausz T,Hughes GR

    更新日期:1986-01-01 00:00:00

  • The renal effects of the addition of low-dose aspirin to COX-2 selective and nonselective antiinflammatory drugs.

    abstract:OBJECTIVE:We aimed to evaluate the effect on renal functions and blood pressure of the addition of low dose aspirin (LDA) to cyclooxygenase-2 (COX-2) inhibitors or nonselective NSAIDs. METHODS:Two groups each containing 14 patients with one group using celecoxib and the other indomethacin regularly for at least 1 week...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,信件

    doi:10.1007/s10067-005-1167-9

    authors: Pamuk ON,Cakir N

    更新日期:2006-02-01 00:00:00

  • Severity of symptoms persists for decades in fibromyalgia-a 26-year follow-up study.

    abstract::The aim of this study is to find out the outcome of 28 patients who got the diagnosis of primary fibromyalgia (pFM) 26 years ago. In 1986, 56 patients with widespread pain were examined and filled in a base questionnaire (BQ). Of them, 42 fulfilled the Yunus criteria for pFM. Twenty-six years later, addresses of 38 pa...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3967-0

    authors: Isomeri R,Mikkelsson M,Partinen M,Kauppi MJ

    更新日期:2018-05-01 00:00:00

  • Effect of ankylosing spondylitis on health-related quality of life and different aspects of social life in young patients.

    abstract::The aim of this study was to determine the emotional and sociodemographic characteristics of patients with ankylosing spondylitis (AS) and to investigate the impact of the disease on their social life and quality of life (QOL). This study included 101 patients with the diagnosis of AS. All patients filled in a questio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-1150-5

    authors: Ozgül A,Peker F,Taskaynatan MA,Tan AK,Dinçer K,Kalyon TA

    更新日期:2006-03-01 00:00:00

  • In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up.

    abstract::This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n=90) were included prospectively and followed up ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2569-3

    authors: Emad Y,Anbar A,Abo-Elyoun I,El-Shaarawy N,Al-Hanafi H,Darwish H,Gamil M,Rasker JJ

    更新日期:2014-06-01 00:00:00

  • Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction.

    abstract::Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diag...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-1074-y

    authors: Ebina K,Fukuhara A,Ando W,Hirao M,Koga T,Oshima K,Matsuda M,Maeda K,Nakamura T,Ochi T,Shimomura I,Yoshikawa H,Hashimoto J

    更新日期:2009-04-01 00:00:00

  • Idiopathic portal hypertension associated with systemic sclerosis and Sjögren's syndrome.

    abstract::We report a patient with idiopathic portal hypertension (IPH) associated with systemic sclerosis (SSc) and Sjögren's syndrome. A 72-year-old Japanese woman was admitted to our hospital because of Raynaud's phenomenon, sclerodactyly, and dyspnea. The patient had splenomegaly, esophageal varices in the absence of extrah...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-1084-y

    authors: Kogawa H,Migita K,Ito M,Takii Y,Daikoku M,Nakao M,Miyashita T,Kimura H,Ezaki H,Nakamura M,Yatsuhashi H,Eguchi K,Ishibashi H

    更新日期:2005-09-01 00:00:00

  • Methotrexate-treated arthritis and lymphoproliferative disease--coincidence only?

    abstract::This paper describes four patients with inflammatory joint diseases treated with methotrexate who developed lymphoma either of unusual type or with bizarre clinical features. The pathogenesis of this unusual condition is discussed and the difficulty in differentiating it from the features of the initial disease is emp...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670170112

    authors: Braun-Moscovici Y,Schapira D,Balbir-Gurman A,Nahir AM

    更新日期:2001-01-01 00:00:00

  • Potential risk factors for reactive arthritis and persistence of symptoms at 2 years: a case-control study with longitudinal follow-up.

    abstract::The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 month...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3911-3

    authors: Garcia Ferrer HR,Azan A,Iraheta I,Von Feldt J,Espinoza LR,Manasson J,Scher JU,Garcia Kutzbach A,Ogdie A

    更新日期:2018-02-01 00:00:00

  • Systems to assess the progression of finger joint osteoarthritis and the effects of disease modifying osteoarthritis drugs.

    abstract::Our objective was to assess the progression of osteoarthritis (OA) using scoring systems based on the anatomical changes recorded in the finger joints on standard radiographs and to test how far these scoring systems could be used to evaluate the effects of candidate "disease modifying osteoarthritis drugs" (DMOAD). T...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s10067-002-8290-7

    authors: Verbruggen G,Goemaere S,Veys EM

    更新日期:2002-06-01 00:00:00

  • Glucocorticoid and cyclosporine refractory adult onset Still's disease successfully treated with tocilizumab.

    abstract::We report a 29-year-old Japanese woman with disseminated intravascular coagulation (DIC) and adult onset Still's disease (AOSD). Her disease was refractory to high-dose glucocorticoids, two courses of steroid pulse therapy, and addition of cyclosporine (3.5 mg/kg/day). The serum interleukin-6 level was markedly elevat...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1097-z

    authors: Matsumoto K,Nagashima T,Takatori S,Kawahara Y,Yagi M,Iwamoto M,Okazaki H,Minota S

    更新日期:2009-04-01 00:00:00