Abstract：
:Antinuclear antibody (ANA) test results frequently affect the course of patients' evaluations, diagnosis, and treatment, but different laboratory centers may yield conflicting results. This study investigated the degree of agreement between laboratory results in a group of subjects who had ANA testing performed at two commercial laboratories. This was a chart review study, in which all ANA tests ordered by the authors from one commercial laboratory over a 4-year period were queried. Corresponding patient charts were reviewed, and if ANA testing had also been performed at the second commercial laboratory, subjects were entered into the study. The primary measurement was agreement between paired ANA results, and we performed sensitivity analysis using varying criteria defining agreement (criteria A to criteria D [strictest to most lenient definition of agreement]). Other data captured included relevant data obtained through the course of evaluation (e.g., presenting complaints, exam findings, other laboratory data) and final diagnoses. Of 101 paired ANA tests, there was 18 % agreement according to the strictest criteria and 42 % according to the most lenient. Of the seven subjects with ANA-associated rheumatic disease, none of the paired tests were in agreement according to criteria A (two agreed according to criteria D). Our findings demonstrate poor agreement between paired ANA tests performed at two commercial laboratories. The low level of agreement may have far-reaching clinical implications. Specifically, this finding calls into question the reliability of ANA testing as it is currently performed and suggests that results may in part depend upon the laboratory center to which patients are referred.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Abeles AM,Gomez-Ramirez M,Abeles M,Honiden Sdoi
10.1007/s10067-016-3241-xsubject
Has Abstractpub_date
2016-07-01 00:00:00pages
1713-8issue
7eissn
0770-3198issn
1434-9949pii
10.1007/s10067-016-3241-xjournal_volume
35pub_type
杂志文章abstract：:Ankylosing spondylitis (AS) is the prototype for spondyloarthritis primarily affecting young men. Geographic and ethnic variations exist in the prevalence and severity of AS and relate to the wide disparity in the frequency of human leukocyte antigen (HLA)-B27, a major genetic risk factor. The strength of the disease ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2058-5
更新日期：2012-11-01 00:00:00
abstract：:Biological agents, particularly anti-Tumour Necrosis Factor (TNF)-α agents, have emerged as an effective treatment in patients with chronic inflammatory diseases. An association between anti-TNF-α antibodies and reactivation of latent tuberculosis infection (LTBI) has been established. Appropriate screening for TB inf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-1938-z
更新日期：2012-05-01 00:00:00
abstract：:The aim of this study was to determine whether the prolactin -1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin -1149 G/T polymorphism and susceptibility to SLE or RA using alle...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-015-2904-3
更新日期：2015-04-01 00:00:00
abstract：:The sternocostoclavicular (SCC) region is subject to the same diseases that occur in joints, with congenital and developmental anomalies, inflammatory and infectious diseases, soft tissue and bone tumors as well as the seronegative spondyloarthropathies, including ankylosing spondylitis, reactive arthritis, enteropath...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-008-0905-1
更新日期：2008-07-01 00:00:00
abstract：:Type B insulin resistance syndrome is characterized by the formation of autoantibodies against insulin receptors, which can cause severe hyperglycemia and insulin resistance. Systemic lupus erythematosus is the most common underlying diseases of the syndrome. This report details our study of a case involving a Chinese...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-012-2098-x
更新日期：2013-02-01 00:00:00
abstract：:We investigated whether headache and family history of headache are risk factors for complex regional pain syndrome (CRPS) or not. Twenty-three CRPS patients and 69 healthy persons were interviewed whether or not they suffered from headache and had first-degree family history of headache. A headache sufferer was defin...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0161-6
更新日期：2006-09-01 00:00:00
abstract：:Determine the effect of daily low divided or single daily dose of prednisone on the longitudinal change in the number of tender and swollen joints and HAQ scores in African Americans (AA) with early rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-017-3943-8
更新日期：2018-02-01 00:00:00
abstract：:The purpose of this study is to evaluate the effects of targeting both the motivation and action phases of behaviour change in a 5-week intervention to increase physical activity (PA) among patients with rheumatoid arthritis (RA) not meeting current PA recommendations. In a randomised controlled trial, a control group...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-013-2425-x
更新日期：2015-02-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is associated with an increased risk of atherosclerotic cardiovascular disease (ACD). The atherogenic index of plasma (AIP), which is the logarithmic transformation of the plasma triglyceride (TG) level to the high-density lipoprotein level (HDL) ratio, has been suggested to be a novel mark...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4027-0
更新日期：2018-05-01 00:00:00
abstract：:The swift and accurate diagnosis of acute arterial occlusion and limb ischemia is critical to prevent morbidity from this vascular emergency as reported by Bettman et al. (Radiology 215:101-105, 2000). There are a number of imaging modalities available to the diagnosing physician. However, the most appropriate modalit...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1419-1
更新日期：2013-03-01 00:00:00
abstract：:This study aimed to compare the diagnostic value of ultrasonography to conventional radiography in detecting osteophytes and erosions in the midfoot joints in patients suffering from inflammatory and non-inflammatory joint disease. Patients with current foot radiographs were included and stratified in two cohorts: inf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3658-x
更新日期：2017-09-01 00:00:00
abstract：:This study aims to compare the mean platelet volume (MPV) levels in children and adults diagnosed with familial Mediterranean fever (FMF) during attack-free periods in order to find out whether it reflects the emergence of microalbuminuria/proteinuria and the development of amyloidosis or not. The study consisted of 6...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2257-8
更新日期：2013-08-01 00:00:00
abstract：:To date, there have been very few studies on the age dependence of maximal isometric muscle strength (MIMS) in healthy subjects aged 20-80 years, based upon measurements of a large number of functional muscle groups (FMGs). Using a hand-held pull gauge it is possible to measure MIMS of nearly every FMG. The objectives...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050026
更新日期：2000-01-01 00:00:00
abstract：:Pulse prednisolone hemisuccinate therapy (500 mg given intravenously on three occasions over two weeks) has been combined with either intramuscular sodium aurothiomalate or azathioprine in an assessment of 30 patients with rheumatoid arthritis. Significant improvement in a variety of clinical and biochemical assessmen...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02204452
更新日期：1988-06-01 00:00:00
abstract：:Hepatitis C-associated osteosclerosis (HCAO) is an impressive example of acquired diffuse osteosclerosis in adults, recently described in ten patients infected with hepatitis C virus (HCV). Its hallmark is a painful and generalized increase of bone mass. Bone biopsies show enhanced accretion rate, usually without hist...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-1031-3
更新日期：2005-06-01 00:00:00
abstract：:The aim of this study was to determine the emotional and sociodemographic characteristics of patients with ankylosing spondylitis (AS) and to investigate the impact of the disease on their social life and quality of life (QOL). This study included 101 patients with the diagnosis of AS. All patients filled in a questio...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-1150-5
更新日期：2006-03-01 00:00:00
abstract：:The aim of this study was to evaluate the safety and efficacy of azathioprine in the treatment of interstitial lung disease (ILD) associated with systemic sclerosis (SSc). The records of patients with SSc with ILD who were treated with azathioprine were reviewed. Patients were treated with azathioprine and low-dose pr...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-004-0906-7
更新日期：2004-08-01 00:00:00
abstract：INTRODUCTION/OBJECTIVES:We hypothesized that mechanical compression of the knee in rheumatoid arthritis (RA) would mobilize occult extractable fluid and improve arthrocentesis success. METHODS:Sixty-seven consecutive knees with RA and 186 knees with OA and were included. Conventional arthrocentesis was performed and s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04524-2
更新日期：2019-08-01 00:00:00
abstract：:We and others have previously shown that IL-17 is elevated in the synovial fluid of patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA) having acute synovitis. Major source for IL-17 is Th17 cells, which differentiate from Th0 cells under the influence of TGF-β and IL-6, IL1-β and are ma...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1646-5
更新日期：2011-06-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) has rarely being reported among African Blacks, in contrast with African-Americans. Such reports have been mostly case reports. Our encounter with new cases shows that this disease may not be rare after all. The objective of this study was to study the clinical presentations, laborat...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1139-6
更新日期：2009-06-01 00:00:00
abstract：:The aim of this study was to describe how persons with rheumatoid arthritis (RA) of working age experience and handle their fatigue in everyday life. Six focus group discussions were conducted focusing on experiences of fatigue in 25 persons with RA (19 women, 6 men), aged 20-60 years. The discussions were recorded, t...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2133-y
更新日期：2013-05-01 00:00:00
abstract：:This study quantified the association between recreational physical activity and daily function in women with fibromyalgia, and determined if this association is mediated by symptoms of pain, depression, or body mass. Twenty-three women diagnosed with fibromyalgia participated in an observational survey study. Recreat...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2386-0
更新日期：2015-01-01 00:00:00
abstract：:To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patient...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02208026
更新日期：1991-03-01 00:00:00
abstract：:This study shows that N-acetyl-galactosamine and N-acetyl-glucosamine can diminish the production of superoxide anion from cytochalasin-B treated PMNs stimulated with FMLP. Inhibition ranged from 80.9% to 1.8%. N-acetyl-galactosamine was superior to N-acetyl-glucosamine, but both showed their action in a dose-related ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02207968
更新日期：1992-06-01 00:00:00
abstract：:Charcot joint or neuropathic arthropathy is described in certain neurological conditions. We report the case of a man who presented with a swollen ankle 10 days after a long walk, which rapidly progressed to a Charcot joint. A neurological examination revealed areflexia and insensitivity to temperature and pain. Elect...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050036
更新日期：2000-01-01 00:00:00
abstract：:To investigate the histological changes of synovium in cases of effect attenuation occurring after the use of infliximab in the treatment of rheumatoid arthritis (RA), we histologically assessed synovial tissue from ten methotrexate-treated RA patients and 12 infliximab-treated RA patients after arthroscopic synovecto...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0850-z
更新日期：2008-06-01 00:00:00
abstract：:Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02229707
更新日期：1996-05-01 00:00:00
abstract：:We report the case of a 45-year-old Caucasian woman suffering from ankylosing spondylitis and undifferentiated connective tissue disease in whom the prevailing clinical features were retinal vasculitis and inflammatory low back pain. HLA typing revealed the concomitant presence of B27 and DR2 antigens. We hypothesise ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01451055
更新日期：1998-01-01 00:00:00
abstract：:In patients with rheumatoid arthritis who had symptomatic knee joints at the start of anti-tumor necrosis factor (TNF) therapy, the relationship between local symptoms and knee joint destruction at 94 weeks was retrospectively investigated. Among the patients with rheumatoid arthritis and received anti-TNF therapy, th...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2181-y
更新日期：2013-06-01 00:00:00
abstract：:The aim of the study was to demonstrate the effectiveness of sulphurous water in patients with osteoarthritis of the hand. Forty-seven patients with osteoarthritis of the hand were enrolled into the double-blind, randomized, controlled study, satisfying ACR criteria. One group of the patients (n = 24) received balneot...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-012-2026-0
更新日期：2012-10-01 00:00:00
