Abstract:
:Hepatitis C-associated osteosclerosis (HCAO) is an impressive example of acquired diffuse osteosclerosis in adults, recently described in ten patients infected with hepatitis C virus (HCV). Its hallmark is a painful and generalized increase of bone mass. Bone biopsies show enhanced accretion rate, usually without histological abnormalities. The HCAO pathogenesis is hitherto unknown. HCV might induce a slow bone cell infection and the production of bone growth factors, such as insulin-like growth factors. Recently, receptor activator of nuclear factor-kappaB (RANK), its ligand (RANKL), and soluble decoy receptor osteoprotegerin (OPG) have been identified as a pivotal cytokine system in the bone remodeling control. We describe the 11th case of HCAO. Notably, the patient's bone biopsy showed the presence of a high number of OPG-positive osteoblasts, a slight increase of RANKL-positive stromal cells, and a dramatic reduction of the osteoclasts. Moreover, OPG serum levels were increased. These findings reported here for the first time are consistent with a pathogenetic role of the OPG/RANKL system imbalance in HCAO.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Manganelli P,Giuliani N,Fietta P,Mancini C,Lazzaretti M,Pollini A,Quaini F,Pedrazzoni Mdoi
10.1007/s10067-004-1031-3subject
Has Abstractpub_date
2005-06-01 00:00:00pages
296-300issue
3eissn
0770-3198issn
1434-9949journal_volume
24pub_type
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