OPG/RANKL system imbalance in a case of hepatitis C-associated osteosclerosis: the pathogenetic key?

Abstract:

:Hepatitis C-associated osteosclerosis (HCAO) is an impressive example of acquired diffuse osteosclerosis in adults, recently described in ten patients infected with hepatitis C virus (HCV). Its hallmark is a painful and generalized increase of bone mass. Bone biopsies show enhanced accretion rate, usually without histological abnormalities. The HCAO pathogenesis is hitherto unknown. HCV might induce a slow bone cell infection and the production of bone growth factors, such as insulin-like growth factors. Recently, receptor activator of nuclear factor-kappaB (RANK), its ligand (RANKL), and soluble decoy receptor osteoprotegerin (OPG) have been identified as a pivotal cytokine system in the bone remodeling control. We describe the 11th case of HCAO. Notably, the patient's bone biopsy showed the presence of a high number of OPG-positive osteoblasts, a slight increase of RANKL-positive stromal cells, and a dramatic reduction of the osteoclasts. Moreover, OPG serum levels were increased. These findings reported here for the first time are consistent with a pathogenetic role of the OPG/RANKL system imbalance in HCAO.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Manganelli P,Giuliani N,Fietta P,Mancini C,Lazzaretti M,Pollini A,Quaini F,Pedrazzoni M

doi

10.1007/s10067-004-1031-3

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

296-300

issue

3

eissn

0770-3198

issn

1434-9949

journal_volume

24

pub_type

杂志文章
  • Histological analysis of synovium in cases of effect attenuation associated with infliximab therapy in rheumatoid arthritis.

    abstract::To investigate the histological changes of synovium in cases of effect attenuation occurring after the use of infliximab in the treatment of rheumatoid arthritis (RA), we histologically assessed synovial tissue from ten methotrexate-treated RA patients and 12 infliximab-treated RA patients after arthroscopic synovecto...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-0850-z

    authors: Kanbe K,Inoue K,Inoue Y,Suzuki Y

    更新日期:2008-06-01 00:00:00

  • A systematic review of the effect of TNF-alpha antagonists on lipid profiles in patients with rheumatoid arthritis.

    abstract::Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-010-1405-7

    authors: Pollono EN,Lopez-Olivo MA,Lopez JA,Suarez-Almazor ME

    更新日期:2010-09-01 00:00:00

  • Secondary amyloidosis in progressive systemic sclerosis.

    abstract::Progressive systemic sclerosis (PSS) is a connective tissue disease that may affect many organs, including the kidneys. It is quite rare to see secondary amyloidosis due to PSS. We present a patient with a 9-year history of PSS who developed nephrotic syndrome, and whose renal biopsy was compatible with secondary amyl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670170048

    authors: Pamuk GE,Pamuk ON,Altiparmak MR,Tanverdi M,Uygun N,Yurdakul S

    更新日期:2001-01-01 00:00:00

  • Ultrasound elastography-based assessment of the elasticity of the supraspinatus muscle in impingement syndrome: does elastography has any diagnostic value?

    abstract::Ultrasound elastography (UE) is a new ultrasound-based imaging technique that provides information about elasticity and stiffness of tissues. This cross-sectional study aimed to identify the diagnostic importance of UE in supraspinatus impingement syndrome. Forty-one subjects, aged 38-70 years, were included in the st...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3928-7

    authors: Demirel A,Baykara M,Koca TT,Berk E

    更新日期:2018-06-01 00:00:00

  • A case of anti-Jo1 myositis with pleural effusions and pericardial tamponade developing after exposure to a fermented Kombucha beverage.

    abstract::The pathogenesis of the idiopathic inflammatory myopathies has been postulated to be an environmental trigger causing the expression of the disease in a genetically predisposed patient. We report a case of anti-Jo1 antibody-positive myositis which was associated with pleural effusions, pericardial effusion with tampon...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-004-0890-y

    authors: Derk CT,Sandorfi N,Curtis MT

    更新日期:2004-08-01 00:00:00

  • Infliximab therapy for familial Mediterranean fever-related amyloidosis: case series with long term follow-up.

    abstract::Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent self-limited attacks of fever and polyserositis. Reactive amyloid A amyloidosis is the most devastating complication of FMF, and amyloidosis continues to occur in the colchicine era in untreated and noncompliant patients. U...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-012-2009-1

    authors: Özçakar ZB,Yüksel S,Ekim M,Yalçınkaya F

    更新日期:2012-08-01 00:00:00

  • Safety and tolerability of duloxetine in the treatment of patients with fibromyalgia: pooled analysis of data from five clinical trials.

    abstract::The purpose of this report is to describe the overall safety profile of both short- and longer-term duloxetine treatment of fibromyalgia. Data from four double-blind, randomized, placebo-controlled studies (two with 6-month open-label extension phases) and a 1-year, open-label safety study were included. Safety measur...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10067-009-1203-2

    authors: Choy EH,Mease PJ,Kajdasz DK,Wohlreich MM,Crits-Christoph P,Walker DJ,Chappell AS

    更新日期:2009-09-01 00:00:00

  • A predictive model for remission and low disease activity in patients with established rheumatoid arthritis receiving TNF blockers.

    abstract::The objective of this study was to identify predictors for remission or low disease activity (LDA) in established rheumatoid arthritis (RA) at 12 months of anti-TNF-α therapy. We have performed a prospective observational study in 90 consecutive patients with active RA receiving TNF-α inhibitors. Baseline and standard...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2146-6

    authors: Pomirleanu C,Ancuta C,Miu S,Chirieac R

    更新日期:2013-05-01 00:00:00

  • CMV enteritis causing ileal perforation in underlying lupus enteritis.

    abstract::We report a case of cytomegalovirus (CMV) enteritis in a 31 year-old -woman with lupus enteritis. In August 2002 the patient complained of severe abdominal pain. An abdominopelvic CT scan at the time showed free air in the peritoneal cavity and wall thickening of the ileal loop. She was diagnosed as having panperitoni...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-003-0825-z

    authors: Bang S,Park YB,Kang BS,Park MC,Hwang MH,Kim HK,Lee SK

    更新日期:2004-02-01 00:00:00

  • Fungal arthritis of the knee caused by Mycoleptodiscus indicus.

    abstract::Mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. It is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. This is the first report of septic arthritis with this fungus in a healthy Canadian male. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1448-9

    authors: Dewar CL,Sigler L

    更新日期:2010-09-01 00:00:00

  • The impact of depression, microvasculopathy, and fibrosis on development of erectile dysfunction in men with systemic sclerosis.

    abstract::This article is a small case series that aims to discuss the impact of depression, vascular, and fibrotic changes on development of erectile dysfunction (ED) in patients with systemic sclerosis (SSc). In this paper, we present five male patients with SSc, aged 30-48 years. All patients are nonsmokers, and their past m...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0567-4

    authors: Ostojic P,Damjanov N

    更新日期:2007-10-01 00:00:00

  • Gout in males: a possible role for COMT hypomethylation.

    abstract:OBJECTIVE:Gout is a common inflammatory disease, and the prevalence of gout in men is significantly higher than in women. Catechol-O-methyltransferase (COMT) regulates dopamine activity and metabolism, thereby participating in the uric acid metabolism, which in turn affects the occurrence of gout. Our study aimed to in...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04607-0

    authors: Ying X,Chen Y,Zheng Z,Duan S

    更新日期:2019-10-01 00:00:00

  • Microangiopathy and forearm arterial blood flow in systemic sclerosis: a controlled study.

    abstract:OBJECTIVE:The aim of the study was to evaluate the interrelationship between the micro- and macrovasculature. METHODS:This is a cross-sectional study that examined SSc patients and fibromyalgia (FM) patients as controls. We assessed forearm peripheral vascular status and nailfold capillaroscopy. We evaluated the assoc...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05025-3

    authors: Bieber A,Dolnikov K,Chizik V,Novofastovsky I,Fawaz A,Balbir-Gurman A,Mader R

    更新日期:2020-09-01 00:00:00

  • Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians.

    abstract::Chronic hepatitis C virus (HCV) viremia has been known to provoke a plethora of autoimmune syndromes referred to as extrahepatic manifestations of chronic HCV infection. Aim of the current study was to assess the prevalence of rheumatologic manifestations among Egyptians with hepatitis C infection and its' association...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1463-x

    authors: Mohammed RH,ElMakhzangy HI,Gamal A,Mekky F,El Kassas M,Mohammed N,Abdel Hamid M,Esmat G

    更新日期:2010-12-01 00:00:00

  • Type I osteogenesis imperfecta: diagnostic difficulties.

    abstract::A 65-year-old woman presented with vertebral fractures of the lumbar spine and a history of pathological fractures following minor trauma, which had occurred before the onset of menopause. Her past medical history was significant for intermittent low back pain since childhood, which was attributed to thoracolumbar sco...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670050052

    authors: Bischoff H,Freitag P,Jundt G,Steinmann B,Tyndall A,Theiler R

    更新日期:1999-01-01 00:00:00

  • Cross-cultural adaptation, validity, and reliability of the Turkish version of the Patient-Rated Elbow Evaluation.

    abstract:INTRODUCTION:The Patient-Rated Elbow Evaluation (PREE) is a joint-specific, self-administered outcome measure used to determine the level of pain and disability in patients with various elbow pathologies. The aim of this study was to cross-culturally adapt the PREE into Turkish (PREE-T) and to test its reliability and ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04665-4

    authors: Hazar Kanik Z,Pala OO,Karabicak GO,Citaker S

    更新日期:2019-11-01 00:00:00

  • The role of outcome expectancies for a training program consisting of meditation, breathing exercises, and cold exposure on the response to endotoxin administration: a proof-of-principle study.

    abstract::Expectancies play a major role for the treatment outcome of a broad variety of immune-mediated conditions and may strengthen or mimic the effects of regular long-term therapies. This study adds to a recently published study of Kox et al. (PNAS 111:7379-7384, 2014) on the ability to voluntarily influence the physiologi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10067-015-3009-8

    authors: van Middendorp H,Kox M,Pickkers P,Evers AW

    更新日期:2016-04-01 00:00:00

  • The effect of anti-TNF agent on oxidation status in patients with ankylosing spondylitis.

    abstract::The aim of this study was to comparatively evaluate oxidative status of ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor (TNF) or non-steroid anti-inflammatory drugs (NSAID). Forty-seven patients with AS and 27 healthy controls were enrolled. Of these, 23 were on anti-TNF (group 1) and 24 on N...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1325-6

    authors: Karkucak M,Capkin E,Alver A,Akyuz A,Kiris A,Ak E,Topbas M,Tosun M

    更新日期:2010-03-01 00:00:00

  • Circulating intercellular adhesion molecules-1 and autoantibodies including anti-endothelial cell, anti-cardiolipin, and anti-neutrophil cytoplasma antibodies in patients with vasculitis.

    abstract::Circulating intercellular adhesion molecule-1 (ICAM-1) and 3 types of autoantibodies were measured in 30 patients with angiographical or pathological proved vasculitis. There were 18 patients with systemic vasculitis and 12 patients with cutaneous vasculitis. The measured antibodies included anti-endothelial cell anti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02231583

    authors: Wang CR,Liu MF,Tsai RT,Chuang CY,Chen CY

    更新日期:1993-09-01 00:00:00

  • Cost of medication errors in rheumatic patients in Mexico.

    abstract::This study aims to measure the frequency of medication error (ME) in rheumatology outpatients of the Social Security System (SS) in Mexico and to measure the costs by comparing the days lost at work as direct consequence of the medication error against the theoretical cost of no error in the process. A prospective 6-m...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1837-8

    authors: Aceves-Avila FJ,Benites-Godínez V,Ramos-Remus C

    更新日期:2011-11-01 00:00:00

  • Priority-setting tools for rheumatology disease referrals: a review of the literature.

    abstract::As part of a larger body of work to develop a rheumatology priority referral score, a literature review was conducted. The objective of the literature review was to identify preexisting priority-setting, triage, and referral tools/scales developed to guide referrals from primary care to specialist care/consultation us...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-0938-5

    authors: De Coster C,Fitzgerald A,Cepoiu M,Investigators of the Western Canada Waiting List Project (WCWL).

    更新日期:2008-11-01 00:00:00

  • Power Doppler ultrasonography of painful Achilles tendons and entheses in patients with and without spondyloarthropathy: a comparison with clinical examination and contrast-enhanced MRI.

    abstract::The objective of this study was to describe ultrasonography (US) and magnetic resonance imaging (MRI) findings at painful Achilles tendons and entheses in patients with and without spondyloarthropathy (SpA and non-SpA) and healthy control persons (CTRLs). Particularly, we aimed to investigate if any changes differenti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2111-4

    authors: Wiell C,Szkudlarek M,Hasselquist M,Møller JM,Nørregaard J,Terslev L,Ostergaard M

    更新日期:2013-03-01 00:00:00

  • Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study.

    abstract::Reduced physical function and health-related quality of life are common in rheumatoid arthritis (RA), and further studies are needed that examine novel determinates of reduced physical function in RA. This study examines whether frailty, a state of increased vulnerability to stressors, is associated with differences i...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10067-017-3541-9

    authors: Andrews JS,Trupin L,Yelin EH,Hough CL,Covinsky KE,Katz PP

    更新日期:2017-05-01 00:00:00

  • Watch out for 'pins and needles' in hands--it may be a case of gout.

    abstract::We encountered only three patients of carpal tunnel syndrome (CTS) due to tophaceous gout during 25 years of practice in a 'hand clinic' situated in a large metropolis in West India. In two patients, the CTS was bilateral, a rare occurrence in gout. There was an unwarranted delay (up to 9 years) in the diagnosis of bo...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0672-4

    authors: Patil VS,Chopra A

    更新日期:2007-12-01 00:00:00

  • Study of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and T-cell-derived (IL-2, IL-4) cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis: correlations with clinical and laboratory parameters.

    abstract::Acute phase proteins, synovial fluid (SF) cellular infiltrates, pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and Th1 (IL-2) and Th2 (IL-4) derived cytokine levels both in plasma and SF were examined in pauciarticular and polyarticular juvenile chronic arthritis (JCA) patients during the active (n = 22) and inactive (...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF01451007

    authors: Kutukculer N,Caglayan S,Aydogdu F

    更新日期:1998-01-01 00:00:00

  • One-year efficacy and safety of single or one to three weekly injections of hylan G-F 20 for knee osteoarthritis: a systematic literature review and meta-analysis.

    abstract::The aim of this study was to evaluate the long-term efficacy and safety of single or 1-3 weekly injections of hylan G-F 20 at 1 year following the first injection for knee osteoarthritis (OA). Searches were conducted in PubMed/MEDLINE, Embase, and CENTRAL and included relevant conference proceedings (January 1, 1995-A...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-020-05477-7

    authors: De Lucia O,Jerosch J,Yoon S,Sayre T,Ngai W,Filippou G

    更新日期:2020-10-27 00:00:00

  • Focal myositis presenting as pseudothrombophlebitis of the arm.

    abstract::We described a 21-year-old woman with a diagnosis of Sjögren syndrome that came for consultation with a localized mass over her left arm of fast growth. Lab results were normal; a Doppler ultrasound showed the presence of partial thrombosis in the left axillary vein; a magnetic resonance imaging showed edema on the bi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-015-3133-5

    authors: Roverano S,Ortiz A,Paira S

    更新日期:2016-04-01 00:00:00

  • Cough as the presenting symptom of large vessel vasculitis.

    abstract::We report the case of a 57-year-old woman presenting with persistent cough, weight loss, and fever. An extensive work-up revealed laboratory signs of inflammation and a mild thickening of the aortic wall on computed tomographic scan of the thorax. These findings raised the suspicion of large vessel vasculitis that was...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-004-1052-y

    authors: Van der Schueren B,Lambert M

    更新日期:2005-08-01 00:00:00

  • Investigations concerning vitamin A transport in rheumatic diseases.

    abstract::The investigation concerned changes in vitamin A derivatives (retinol and retinyl) content in serum of patients suffering from two types of rheumatic diseases--rheumatoid arthritis (RA) and osteoarthrosis. Healthy women of similar age served as control. It was found that the retinol content of the serum in the group s...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02042773

    authors: Mezes M,Bartosiewicz B

    更新日期:1982-09-01 00:00:00

  • Treatment of therapy-resistant sarcoidosis with adalimumab.

    abstract::A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0037-9

    authors: Callejas-Rubio JL,Ortego-Centeno N,Lopez-Perez L,Benticuaga MN

    更新日期:2006-07-01 00:00:00