A case of myeloperoxidase-antineutrophil cytoplasmic antibody positive-polyarteritis nodosa complicated by interstitial pneumonia and rapidly progressive renal failure.

Abstract:

:A 73-year-old woman was admitted to our hospital because of persistent high fever and cough, generalized myalgia, and renal dysfunction. Laboratory examination revealed severe inflammatory signs, pulmonary fibrosis, progression of renal impairment with active nephritic urinary sediments, and a high titer of myeloperoxidase-antineutrophil cytoplasmic antibody, indicating that she might have microscopic polyangiitis with interstitial pneumonia and rapidly progressive glomerulonephritis. Her renal biopsy, however, showed tubulointerstitial changes with mild glomerular abnormalities, and renal angiography revealed that she had vascular lesions of medium-sized arteries, which were compatible with classical polyarteritis nodosa. Tissue biopsy of the clinically affected organ should be considered in anyone suspected to have vasculitis.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Sugimoto T,Kanasaki K,Koyama T,Yokomaku Y,Yasuda H,Kashiwagi A,Koya D

doi

10.1007/s10067-005-0142-9

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

429-32

issue

3

eissn

0770-3198

issn

1434-9949

journal_volume

26

pub_type

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