Abstract:
:In a great majority of patients with systemic lupus erythematosus (SLE) lymphocytotoxic antibodies (LCA) are detected. The reported prevalence depends on the methods of detection and definition of test-positivity. The pathogenetic role of LCA remains unclear. Different reports show that LCA can have an influence on mononuclear cell function, e.g., on production of interferon, or specifically on T-cell function. In several studies T-cell specificity of LCA cannot be shown. Sometimes an overlap between LCA and anti-B2M antibodies is found, suggesting that LCA have anti-B2M activity. Anti-B2M activity might have an impact on T-cell as well as on B cell function. Next to the anti-B2M activity, binding to nuclear material is claimed. Investigating the role of LCA in respect to lymphopenia, a direct relationship cannot be found; however, LCA might induce interferon production, resulting in lymphopenia. Several studies show or claim a relationship between the presence of LCA and neurological manifestations in SLE patients; the results, however, remain questionable due to the difference in detection methods as well as in definition of central nervous system (CNS) involvement. In other studies, an increased incidence of LCA is reported in relatives of SLE patients as well. In addition, LCA are reported in quite a lot of other diseases such as rheumatoid arthritis, ankylosing spondylitis, malignancies and viral illnesses. This latter association has led to the assumption that LCA might have a virus-related origin.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Osman C,Swaak AJdoi
10.1007/BF02229861subject
Has Abstractpub_date
1994-03-01 00:00:00pages
21-7issue
1eissn
0770-3198issn
1434-9949journal_volume
13pub_type
杂志文章,评审abstract::The purpose of the study was to assess the 1-year outcome of definitive reactive arthritis (ReA) after a waterborne outbreak. A cohort of 21 patients (15 females and 6 males, median age 54 years) with ReA related to an extensive waterborne outbreak in Finland was clinically followed-up by rheumatologists with visits a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
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abstract::A pair of identical twins suffering from ankylosing spondylitis is reported. One brother developed an earlier-onset disease and showed ossification of the posterior longitudinal ligament and the flavum ligament in his cervical spine. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02249033
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to develop an understanding of treatment preferences in patients with inflammatory arthritis (IA) [rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)] focussing on treatment attributes that patients' value, their relative importan...
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
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更新日期:1986-09-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
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更新日期:2016-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01451288
更新日期:1998-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0255-9
更新日期:2007-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02238968
更新日期:1997-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:2007-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0970-5
更新日期:2008-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200081
更新日期:2002-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-1083-x
更新日期:2009-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0691-1
更新日期:2008-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-014-2566-6
更新日期:2014-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2098-x
更新日期:2013-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4289-6
更新日期:2018-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4197-9
更新日期:2018-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1343-4
更新日期:2010-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041395
更新日期:1983-09-01 00:00:00
abstract::The aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2540-3
更新日期:2014-05-01 00:00:00