Abstract：
:At the intersection of atopy and autoimmunity, we present a patient with seronegative rheumatoid arthritis (RA) who developed hypereosinophilia, without evidence of other etiologies, as she became rheumatoid factor (RF) positive. Although the magnitude of eosinophilia in patients with RA has been thought to reflect the severity or activity of the RA, in our patient, eosinophilia developed at a time when the patient's synovitis was well controlled. Although eosinophilia may reflect associated drug hypersensitivity, discontinuation of the medications utilized to control our patient's disease, adalimumab and methotrexate, did not promote clinical improvement. Probably the most curious aspect of our patient was the concomitant development of rheumatoid factor seropositivity in the setting of previously seronegative RA. The temporal relationship between the development of peripheral eosinophilia and seroconversion suggests a possible connection between these events. We speculate that the T cell cytokine production that can induce eosinophilia may simultaneously activate RF production.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Rosenstein RK,Panush RS,Kramer N,Rosenstein EDdoi
10.1007/s10067-014-2566-6subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1685-8issue
11eissn
0770-3198issn
1434-9949journal_volume
33pub_type
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