Abstract:
:Tumour necrosis factor alpha (TNF alpha) and interleukin-2 (IL-2) are potential immunological mediators of pathogenetic changes in rheumatoid arthritis. We measured the concentrations of TNF alpha and IL-2 in plasma from 2 groups of patients suffering from rheumatoid arthritis (RA). One group had high and one had low disease activity. In addition, in connection with steroid treatment in the high disease activity group, TNF alpha was significantly increased in plasma from RA patients with high disease activity compared with those of low disease activity (p = 0.0009). Furthermore, TNF alpha decreased significantly in relation to steroid medication, parallel to clinical improvement (p = 0.016). All IL-2 concentration measurements were within the estimated normal range. The increased TNF alpha plasma levels in patients with rheumatoid arthritis with high disease activity, might result from activated white mononuclear cells in the inflamed joints. This might, in part, support the theory that TNF alpha is a possible mediator of pathogenetic changes known to occur in rheumatoid arthritis.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Espersen GT,Vestergaard M,Ernst E,Grunnet Ndoi
10.1007/BF02206655subject
Has Abstractpub_date
1991-12-01 00:00:00pages
374-6issue
4eissn
0770-3198issn
1434-9949journal_volume
10pub_type
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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更新日期:1995-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
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更新日期:1996-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1994-09-01 00:00:00
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02201003
更新日期:1987-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3707-5
更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
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更新日期:2006-02-01 00:00:00
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更新日期:2019-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2202-x
更新日期:2013-04-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:2013-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00