Proteoglycan metabolism in isolated chondrocytes from human cartilage. Influence of niflumic acid.

Abstract:

:The effect of niflumic acid on hyaluronic acid and proteoglycan metabolism of human cartilage cells was investigated in vitro. Cartilage cells were obtained from five different donors. Niflumic acid levels used in the test systems ranged from 0 to 22 microgramsr/ml and were comparable to serum concentrations in humans after oral intake. Niflumic acid increased the synthesis rates of proteoglycan in some batches of isolated and monolayer-cultured chondrocytes. The effect on hyaluronate synthesis was less pronounced. The fact that this increase in the synthesis of proteoglycan was restricted to some of the donors whereas isolated cells or tissue samples from other individuals remained unaffected illustrates the heterogeneity of different human donors. Depression of proteoglycan synthesis in the presence of the drug was never observed.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Verbruggen G,Veys EM,Malfait AM,Schatteman L,Wieme N,Nimmegeers J,Gerin MG,Broddelez C

doi

10.1007/BF02030238

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

32-41

issue

1

eissn

0770-3198

issn

1434-9949

journal_volume

9

pub_type

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