Abstract:
:The effect of niflumic acid on hyaluronic acid and proteoglycan metabolism of human cartilage cells was investigated in vitro. Cartilage cells were obtained from five different donors. Niflumic acid levels used in the test systems ranged from 0 to 22 microgramsr/ml and were comparable to serum concentrations in humans after oral intake. Niflumic acid increased the synthesis rates of proteoglycan in some batches of isolated and monolayer-cultured chondrocytes. The effect on hyaluronate synthesis was less pronounced. The fact that this increase in the synthesis of proteoglycan was restricted to some of the donors whereas isolated cells or tissue samples from other individuals remained unaffected illustrates the heterogeneity of different human donors. Depression of proteoglycan synthesis in the presence of the drug was never observed.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Verbruggen G,Veys EM,Malfait AM,Schatteman L,Wieme N,Nimmegeers J,Gerin MG,Broddelez Cdoi
10.1007/BF02030238subject
Has Abstractpub_date
1990-03-01 00:00:00pages
32-41issue
1eissn
0770-3198issn
1434-9949journal_volume
9pub_type
杂志文章abstract::Forty-three of fifty-eight (74.1%) female patients with fibromyalgia completed an eight-week treatment period testing the combination of carisoprodol, paracetamol (acetaminophen) and caffeine versus placebo. Twenty-three patients received placebo and twenty active medication. In the placebo group 56.5% of the patients...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02030081
更新日期:1989-06-01 00:00:00
abstract::The relations between parameters obtained by clinical absorptiometric techniques, such as SPA, DPA, DXA and QCT, and geometrical and material parameters of bone structures are investigated. Two types of bone are considered: the diaphysis of a long bone, modelled as a hollow cylindrical structure consisting of compact ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the relationship among smoking, TNF-α-blocker therapy, and the dynamic changes in gut microbiota in patients with ankylosing spondylitis (AS). METHODS:Using a 16S rRNA sequence, 98 fecal samples of 20 AS patients collected after 0, 1, 3 and 6 months of anti-TNF-α treatment an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05032-4
更新日期:2020-09-01 00:00:00
abstract::A variety of cardiovascular clinical manifestations have been described in patients with spondyloarthritis, especially in well-established ankylosing spondylitis. These include both structural heart disease, conduction defects and ischemic heart disease. The true prevalence of cardiovascular involvement in patients wi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-2959-1
更新日期:2015-06-01 00:00:00
abstract::There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-013-2342-z
更新日期:2013-11-01 00:00:00
abstract::Psoriatic arthritis (PsA) is a chronic T cell-mediated inflammatory spondyloarthropathy affecting 10-40 % of psoriasis (PSO) patients (0.3-1.0 % of the general population). Recent epidemiological studies have shown an increased prevalence of cardiovascular (CV) risk factors and/or morbidity among PSO or PsA patients a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2743-7
更新日期:2014-01-01 00:00:00
abstract::The involvement of brain-derived neurotrophic factor (BDNF) in rheumatoid arthritis (RA) is largely unknown. The distribution of BDNF and its associated receptors, TrkB and p75, in the synovial tissue of patients with RA was examined and contrasted with that in patients with osteoarthritis (OA). Additionally, levels o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0910-4
更新日期:2008-10-01 00:00:00
abstract::The aim of this study was to evaluate in systemic sclerosis (SSc) retrospectively the effect of Bosentan and Sildenafil and their combination on Raynaud's phenomenon (RP), function, and capillaroscopic patterns. One hundred and twenty-three SSc patients (mean age ± sd, 57.69 ± 14.07 years) were retrospectively evaluat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3119-3
更新日期:2016-01-01 00:00:00
abstract::This study aims to identify the clinical predictors of arthritis in patients with psoriasis and to evaluate the use of musculoskeletal ultrasonography (US) as a predictor for inflammatory structural progression in psoriatic patients. Measures of association (odds ratio (OR)) were tested, in a prospective, cohort 1-yea...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2630-2
更新日期:2015-02-01 00:00:00
abstract::Musculoskeletal disorders represent a large and growing clinical challenge to primary care clinicians. Unfortunately, there appears to be a gap in current training and continuing education to meet this challenge. We used script concordance within a continuing medical education program entitled "Joint Adventures" to as...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0446-4
更新日期:2007-07-01 00:00:00
abstract::Articular involvement is described in a 58-year-old female patient with scleroderma. Radiological findings included intra-articular calcification, destructive osteoarthritis and selective involvement of the first metacarpal base. The discussion attempts to explain the way in which intra-articular calcification and ost...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032338
更新日期:1984-09-01 00:00:00
abstract::Employing a recently developed questionnaire we studied the self-esteem structure of 61 female fibromyalgia (FM) patients by comparing them with i) 40 healthy psychology students and ii) 37 patients suffering from rheumatoid arthritis. Depressed FM patients (n=36) had a high need to gain self-esteem through competence...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02247798
更新日期:1997-11-01 00:00:00
abstract::Muscle pain and weakness in a rheumatoid arthritis (RA) patient has a broad differential, and myositis should be considered early in the disease course as serious limb and life-threatening sequelae may occur. A 55-year-old woman with a past medical history of methotrexate-controlled RA presented with right leg pain fo...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-014-2657-4
更新日期:2015-10-01 00:00:00
abstract::To compare the efficacy and safety of aceclofenac (AC) and tenoxicam (TX) in the treatment of rheumatoid arthritis (RA), a multicentric parallel, randomized, double-blind trial of three months duration was performed in 292 patients: 145 were randomized to the AC treatment group and 147 to the TX treatment group. The t...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF02229644
更新日期:1996-09-01 00:00:00
abstract::We investigated the association between smoking and the disease activity, functional ability, physical mobility, and systemic inflammation in Chinese ankylosing spondylitis (AS) patients. Seventy five male Chinese AS patients in Taiwan were enrolled in the cross-sectional study. These patients fulfilled the 1984 modif...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2165-y
更新日期:2013-05-01 00:00:00
abstract::The objective of this study is to identify the clinical differences between infectious meningitis and neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with SLE. Clinical manifestations, laboratory test results, and prognoses of 14 SLE patients complicated with various infectious meningitis, hospitaliz...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2726-8
更新日期:2015-02-01 00:00:00
abstract::The aim of this study was to evaluate whether modifiable cardiovascular disease (CVD) risk factors, e.g. atherogenic blood lipids, hypertension and lifestyle-related factors such as smoking, diet and physical inactivity, differ among patients with ankylosing spondylitis (AS) in comparison to the general population. Ei...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2410-4
更新日期:2014-01-01 00:00:00
abstract::In this scoping review, we sought to summarize the types of outcomes collected in pregnant patients with ankylosing spondylitis (AS), and to identify some methodological limitations related to pregnancy research in these patients. A comprehensive search was done to identify relevant articles in MEDLINE and Embase. We ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-021-05588-9
更新日期:2021-01-19 00:00:00
abstract::A prospective, randomised, double-blind study was carried out to compare the respective efficacies of transforaminal and interspinous epidural corticosteroid injections in discal radiculalgia. Thirty-one patients (18 females, 13 males) with discal radicular pain of less than 3 months' duration were consecutively rando...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s10067-003-0736-z
更新日期:2003-10-01 00:00:00
abstract::We encountered only three patients of carpal tunnel syndrome (CTS) due to tophaceous gout during 25 years of practice in a 'hand clinic' situated in a large metropolis in West India. In two patients, the CTS was bilateral, a rare occurrence in gout. There was an unwarranted delay (up to 9 years) in the diagnosis of bo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0672-4
更新日期:2007-12-01 00:00:00
abstract::To compare Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA) with PCP in patients with non-RA connective tissue diseases (CTDs) in order to clarify the characteristics of the former. We extracted consecutive patients satisfying the following criteria for "clinical PCP": (1) positive plasma β-D-gl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4157-4
更新日期:2018-08-01 00:00:00
abstract::Seventy-nine patients suffering from rheumatoid factor positive rheumatoid arthritis (RA) were included in this study. In each patient disease activity was assessed three times at two-week intervals during a four-week period. All factors that might possibly influence RA, except atmospheric conditions (AC) were held co...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206665
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVES:The invalidation or social pain is an important but neglected issue in polysymptomatology of fibromyalgia (FM). This study sought whether tracing-perceived invalidation could be effective to discriminate between the presence and absence of FM in chronic pain patients with respect to five different sources, i...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05515-4
更新日期:2021-01-07 00:00:00
abstract::Pulse therapy is one of the most well-known methods used in the treatment of juvenile rheumatoid arthritis. This study assessed the outcome of methylprednisolone pulse therapy, its rate of efficacy, and its associated complications in patients with juvenile rheumatoid arthritis (JRA). This cross-sectional study was pe...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0919-8
更新日期:2008-11-01 00:00:00
abstract::The aim of this study was to evaluate clinical remission and MDA in PsA patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Concomitant therapies as well as comorbidities were assessed. Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3769-4
更新日期:2017-10-01 00:00:00
abstract::Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic diseases and concomitant Chagas disease under RT to detect CDR and to describe a possible relationship between CDR and specific RT. An observational, ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-021-05581-2
更新日期:2021-01-12 00:00:00
abstract::The level of the N terminal fragment of procollagen III (P3NP) levels of 100 consecutive patients affected by rheumatoid arthritis (RA) were evaluated in comparison with disease activity markers (erythrocytes sedimentation rate, C reactive protein), immunological status (rheumatoid factors, immune complexes) and joint...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02283106
更新日期:1992-12-01 00:00:00
abstract::To study the clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia (AIRD-OP), the clinical presentation, radiological findings, treatment, and outcome of AIRD-OP patients were analyzed, in comparison with patients with cryptogenic organizing pneumonia (COP). A total of 131 OP patients w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3694-6
更新日期:2018-04-01 00:00:00
abstract::Ochronosis involves primarily the large cartilaginous joint surfaces, ribs, intervertebral discs, ear cartilage etc. We report on a 53-year-old woman with typical alkaptonuric ochronosis with dark urine, blue-black pigmentation of the auriculae and hands, focal brown hyperpigmentation of the sclera, spondylarthropathy...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-002-8277-4
更新日期:2002-05-01 00:00:00
abstract::Our aim was to determine reasons for admission, the prevalence and spectrum of infections, and the outcomes in a multiethnic cohort of hospitalized systemic lupus erythematosus (SLE) patients in Durban, South Africa. We reviewed the records of hospitalized SLE patients seen over a 79-month period; the demographic data...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2847-0
更新日期:2015-03-01 00:00:00