Prognostic significance of complement alleles Bf and C4 in early rheumatoid arthritis.

Abstract:

:The prognostic significance of class III major histocompatibility complex complement components, factor B (Bf), C4A and C4B, were studied in a 3-year prospective study of 73 patients with early RA. Patients with C4B null allele had higher disease activity with more radiological progression than patients with C4A null allele or patients without null allele. C4B null allele also associated with increased susceptibility to side effects from antirheumatic treatment. The Bf phenotypes did not associate with the severity of RA. C4B null allele may have prognostic significance in determining a special subgroup of RA patients with a more complicated course of the disease.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Paimela L,Leirisalo-Repo M,Lokki ML,Koskimies S

doi

10.1007/BF02238550

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

594-8

issue

6

eissn

0770-3198

issn

1434-9949

journal_volume

15

pub_type

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