Abstract:
:This study aims to characterize the clinical features of a cohort of patients diagnosed with systemic sclerosis (SSc) after the age of 75 and compare them to a group diagnosed at a younger age. We record the review of 769 patients diagnosed with SSc over the past 16 years. Utilizing a nested case-control model, we compare demographics, disease severity, morbidity, and mortality data of all patients diagnosed after the age of 75 to sex- and disease-type-matched, randomly selected group of patients diagnosed with SSc before the age of 60. Twelve patients were diagnosed with SSc after the age of 75, seven with the diffuse, and five with the limited form. It took longer to diagnose SSc in the older patients, and comparison of disease severity revealed a worse pulmonary picture and a more frequent development of malignancy in the older patients as compared with the younger ones. During a mean follow-up of 36.2 months, our cohort of patients did not have worsening in their disease severity, though 6 months after the last follow-up, six patients died. We conclude that a diagnosis of SSc at an older age appears to be a poor prognostic indicator related to both disease severity and comorbidities. A higher clinical suspicion will lead to an earlier diagnosis and a potential decrease in morbidity and mortality.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Derk CT,Artlett CM,Jimenez SAdoi
10.1007/s10067-005-0177-ysubject
Has Abstractpub_date
2006-11-01 00:00:00pages
831-4issue
6eissn
0770-3198issn
1434-9949journal_volume
25pub_type
杂志文章abstract:OBJECTIVE:MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, m...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05573-8
更新日期:2021-01-02 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of the commonly used urate-lowering therapies (ULTs): febuxostat, allopurinol, and lesinurad in hyperuricemic patients with gout. METHODS:We included all randomized controlled trials (RCTs) that compared ULTs with placebo or head to head. The primary efficacy endpoint was t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05272-4
更新日期:2021-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3282-1
更新日期:2016-11-01 00:00:00
abstract::Diffuse systemic sclerosis and the related syndromes were diagnosed in 115 patients during 1977-1987. Sixty-nine patients were available for clinical evaluation and analysis. These included 46 patients with diffuse systemic sclerosis, 2 with limited cutaneous systemic sclerosis, 2 with linear scleroderma, 18 with over...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207649
更新日期:1991-06-01 00:00:00
abstract::Heterogenous population of cells, including macrophages, synoviocytes and lymphocytes play important roles in the immunopathogenesis of rheumatoid arthritis (RA). T cells, however, seem to be a common thread throughout the disease process. In inhibiting T lymphocytes, cyclosporin A presents a more selective form of th...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02215854
更新日期:1995-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05306-x
更新日期:2020-08-14 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04665-4
更新日期:2019-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2747-3
更新日期:2014-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-1987-3
更新日期:2012-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/pl00011180
更新日期:2000-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2344-x
更新日期:2013-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05025-3
更新日期:2020-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-2883-4
更新日期:2015-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-3133-5
更新日期:2016-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207092
更新日期:1992-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0999-5
更新日期:2009-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-016-3261-6
更新日期:2016-06-01 00:00:00
abstract::Distinction between infection and febrile disease flare in patients with systemic lupus erythematosus (SLE) is fundamental but often difficult to make, because clinical presentation can be similar. A systematic review of all articles indexed in PubMed through October 2013 was performed, in order to examine the potenti...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-014-2738-4
更新日期:2014-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-04925-8
更新日期:2020-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0255-9
更新日期:2007-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208035
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4138-7
更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s10067-008-0905-1
更新日期:2008-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3787-2
更新日期:2017-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02207098
更新日期:1992-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF02229644
更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-007-0567-4
更新日期:2007-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0691-1
更新日期:2008-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-002-0676-z
更新日期:2003-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2776-y
更新日期:2016-01-01 00:00:00