Abstract:
:Distinction between infection and febrile disease flare in patients with systemic lupus erythematosus (SLE) is fundamental but often difficult to make, because clinical presentation can be similar. A systematic review of all articles indexed in PubMed through October 2013 was performed, in order to examine the potential role of procalcitonin (PCT) for the discrimination between SLE flare and infection. Among the 12 papers identified, 5 articles reported on PCT levels in SLE patients without infection, 6 compared PCT levels between SLE patients with flare versus those with infection, and 1 analyzed PCT levels in active patients with and without bacterial infection. These data suggest the absence of correlation between PCT levels and SLE disease activity. Furthermore, PCT levels detected during disease flares are lower than those observed during bacterial infections. PCT can therefore be used accurately in the early differentiation between bacterial infection and flare in febrile SLE patients. Raised PCT levels ≥0.5 μg/L should strongly suggest bacterial infection in the context of SLE, keeping in mind the limited data available in case of hemophagocytic syndrome. Elevated PCT levels in SLE patients should always prompt a thorough search for sources of potential infection.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Serio I,Arnaud L,Mathian A,Hausfater P,Amoura Zdoi
10.1007/s10067-014-2738-4subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1209-15issue
9eissn
0770-3198issn
1434-9949journal_volume
33pub_type
杂志文章,评审abstract::The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1528-x
更新日期:2010-11-01 00:00:00
abstract::The aim of this study was to describe how persons with rheumatoid arthritis (RA) of working age experience and handle their fatigue in everyday life. Six focus group discussions were conducted focusing on experiences of fatigue in 25 persons with RA (19 women, 6 men), aged 20-60 years. The discussions were recorded, t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2133-y
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-017-3787-2
更新日期:2017-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207965
更新日期:1992-06-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-014-2743-7
更新日期:2014-01-01 00:00:00
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doi:10.1007/BF02201003
更新日期:1987-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1998-01-01 00:00:00
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更新日期:2019-08-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:1994-12-01 00:00:00