Abstract:
:To compare the efficacy and safety of aceclofenac (AC) and tenoxicam (TX) in the treatment of rheumatoid arthritis (RA), a multicentric parallel, randomized, double-blind trial of three months duration was performed in 292 patients: 145 were randomized to the AC treatment group and 147 to the TX treatment group. The trial was completed by 237 (81.1%) patients. Both treatment groups showed amelioration of clinical parameters monitored at 15 days, and this improvement continued until the end of the trial, no statistically significant differences being observed between AC and TX. Twenty-four patients (8.2%, 12 AC and 12 TX) did not complete the trial because of inefficacy, and 15 because of side effects (5.1%, 6 AC and 9 TX), in 7 of them due to gastrointestinal intolerance (2,4%, 1 AC, 6 TX, p = 0.052). These data demonstrate that AC shows similar efficacy to TX in the treatment of rheumatoid arthritis and better safety profile than TX, mainly regarding gastrointestinal tolerability.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Perez-Ruiz F,Alonso-Ruiz A,Ansoleaga JJdoi
10.1007/BF02229644subject
Has Abstractpub_date
1996-09-01 00:00:00pages
473-7issue
5eissn
0770-3198issn
1434-9949journal_volume
15pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract::A white female patient developed overlapping features of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) with severe pulmonary compromise. She was treated with steroids and azathioprine, which improved her clinical condition and spirometric status. In May 2002 she presented with continuous pain in her ...
journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
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更新日期:1998-01-01 00:00:00
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