Abstract:
:Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, showing a high incidence of lung involvements. The aim of this study is to identify risk factors, other than melanoma differentiation-associated protein (MDA)-5, for developing rapidly progressive-interstitial lung disease (RP-ILD) in patients with CADM. Forty CADM patients, in whom 11 patients developed RP-ILD, were enrolled. Clinical features and laboratory findings were compared between the patients with and without RP-ILD. We found that skin ulceration, CRP, serum ferritin, anti-MDA5 Ab, and lymphocytopenia were significantly associated with ILD. Multivariate logistic regression analysis indicated that anti-MDA5 Ab(+), elevated CRP, and decreased counts of lymphocyte were independent risk factors for RP-ILD, which can provide a precise predict for RP-ILD in CADM patients. When anti-MDA5 Ab(+) was removed from the multivariate regression model, using skin ulcerations, elevated serum ferritin and decreased counts of lymphocyte can also precisely predict RP-ILD. Except for MDA-5, more commonly available clinical characteristics, such as skin ulcerations, serum ferritin, and count of lymphocyte may also help to predict prognosis in CADM.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Xu Y,Yang CS,Li YJ,Liu XD,Wang JN,Zhao Q,Xiao WG,Yang PTdoi
10.1007/s10067-015-3139-zsubject
Has Abstractpub_date
2016-01-01 00:00:00pages
113-6issue
1eissn
0770-3198issn
1434-9949pii
10.1007/s10067-015-3139-zjournal_volume
35pub_type
杂志文章abstract:INTRODUCTION:Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal tract, and kidney involvement. Microribonucleic acids (miRNAs) are 18-25 base-long non-coding RNA group acting on gene expression. They ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05441-5
更新日期:2020-10-10 00:00:00
abstract::The aim of this study was to investigate generalized osteoarthritis (GOA) by combining X-ray grading of the knee, spine and hand using biochemical markers for arthritis, such as YKL-40 and urinary pyridinoline (Pyr). One hundred and thirty postmenopausal women with primary knee osteoarthritis (OA) aged 55-92 years wer...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0802-6
更新日期:2003-12-01 00:00:00
abstract::Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyosi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0346-7
更新日期:2007-07-01 00:00:00
abstract::The objective of the current work is to report our preliminary experience with the mizoribine (MZR) intermittent pulse protocol for induction therapy for newly diagnosed pediatric-onset systemic lupus erythematosus (SLE). Five consecutive patients who were newly diagnosed as having SLE with biopsy-proven lupus nephrit...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10067-007-0635-9
更新日期:2008-01-01 00:00:00
abstract::To investigate the histological changes of synovium in cases of effect attenuation occurring after the use of infliximab in the treatment of rheumatoid arthritis (RA), we histologically assessed synovial tissue from ten methotrexate-treated RA patients and 12 infliximab-treated RA patients after arthroscopic synovecto...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0850-z
更新日期:2008-06-01 00:00:00
abstract::Juvenile dermatomyositis (JDM) is a rare chronic inflammatory disease of unknown etiology and primarily involves muscle and skin. It is the most common idiopathic inflammatory myopathy of childhood. This study aimed to evaluate demographic and clinical features, laboratory data, treatment modalities, and outcome of pa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3530-4
更新日期:2017-02-01 00:00:00
abstract::Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2127-9
更新日期:2013-03-01 00:00:00
abstract::In order to assess the clinical equivalence between deflazacort oral drops and tablets, 18 patients with active rheumatoid arthritis were enrolled in an open, controlled, randomised ('tablets --> drops' sequence, or vice versa), two-period (21 days each) crossover trial (from tablets to drops, or vice versa). Individu...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s100670050072
更新日期:1999-01-01 00:00:00
abstract::Although peripheral blood eosinophilia is observed in patients with active inflammatory rheumatoid arthritis (RA), RA is not a recognised cause of pulmonary eosinophilia. We describe a 55-year-old woman affected by chronic eosinophilic pneumonia (CEP) concomitantly with an initiation of RA. Both diseases responded rap...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0703-8
更新日期:2003-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the production of autoantibodies and the involvement of multiple organ systems. Systemic sclerosis (SSc) is another autoimmune disease that causes fibrosis. We will aim to analyse the role of killer cell immunoglobulin-like receptor (KIR) gen...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3222-0
更新日期:2016-04-01 00:00:00
abstract::To validate the Quality of Life-Rheumatoid Arthritis Scale II (QOL-RA II) in an Argentinean cohort of patients with rheumatoid arthritis (RA). Patients ≥ 18 years old, with a diagnosis of RA according to ACR-EULAR 2010 criteria, were included in a cross-sectional study. Sociodemographic data, comorbidities, RA charact...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05139-8
更新日期:2020-11-01 00:00:00
abstract::Antibodies to beta(2)-glycoprotein I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). We investigated the sensitivity and specificity of ELISA for anti-beta(2)-GPI in Thai systemic lupus...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0566-5
更新日期:2007-10-01 00:00:00
abstract::Sternoclavicular septic arthritis is a rare complication of subclavian venous catheterization. We estimate that septic involvement of this joint may be as common as one in 500 catheterizations. We report two patients with insidious onset of shoulder pain, chest discomfort, low-grade fever and slight but painful swelli...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02242953
更新日期:1994-09-01 00:00:00
abstract::A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0037-9
更新日期:2006-07-01 00:00:00
abstract::Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic diseases and concomitant Chagas disease under RT to detect CDR and to describe a possible relationship between CDR and specific RT. An observational, ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-021-05581-2
更新日期:2021-01-12 00:00:00
abstract::In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2317-0
更新日期:2013-11-01 00:00:00
abstract::In the study of pathophysiological mechanisms in growth abnormalities of the juvenile knee in arthritis an animal model in dogs was developed. Arthritis was induced by intra-articular injections of Carrageenan. Prominent growth changes were enlargement of the distal femoral epiphysis, patellar squaring and decreased e...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030752
更新日期:1984-06-01 00:00:00
abstract::The objective of this study is to identify the clinical differences between infectious meningitis and neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with SLE. Clinical manifestations, laboratory test results, and prognoses of 14 SLE patients complicated with various infectious meningitis, hospitaliz...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2726-8
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:We hypothesized that mechanical compression of the knee in rheumatoid arthritis (RA) would mobilize occult extractable fluid and improve arthrocentesis success. METHODS:Sixty-seven consecutive knees with RA and 186 knees with OA and were included. Conventional arthrocentesis was performed and s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04524-2
更新日期:2019-08-01 00:00:00
abstract::The Revised Fibromyalgia Impact Questionnaire (FIQR) attempts to address the limitations of the Fibromyalgia Impact Questionnaire (FIQ). As there is no Turkish version of the FIQR available, we aimed to investigate the validity and reliability of a Turkish translation of the FIQR in Turkish female fibromyalgia (FM) pa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1546-8
更新日期:2011-03-01 00:00:00
abstract::The objective of this study was to identify predictors for remission or low disease activity (LDA) in established rheumatoid arthritis (RA) at 12 months of anti-TNF-α therapy. We have performed a prospective observational study in 90 consecutive patients with active RA receiving TNF-α inhibitors. Baseline and standard...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2146-6
更新日期:2013-05-01 00:00:00
abstract::The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed by maintenance treatment with other mild immunosuppressive agents on lung function in scleroderma (SSc) patients. Thirty patients with SSc (mean age 52 years, mean disease duration < 2 years) with forced vit...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4266-0
更新日期:2018-11-01 00:00:00
abstract::Determine the effect of daily low divided or single daily dose of prednisone on the longitudinal change in the number of tender and swollen joints and HAQ scores in African Americans (AA) with early rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-017-3943-8
更新日期:2018-02-01 00:00:00
abstract::Juvenile idiopathic arthritis (JIA) has rarely been reported among Black Africans. This retrospective case study was part of an audit of cases presenting to a private practice rheumatology clinic in Lagos, Nigeria. The objective of this study was to determine the clinical, laboratory, and radiographic features of pati...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1401-y
更新日期:2010-07-01 00:00:00
abstract::The Bath ankylosing spondylitis metrology index (BASMI; range 0-10) has gained widespread use in daily clinical practice as an objective measure of spinal stiffness not only in patients with ankylosing spondylitis (AS) but also in patients with other spondylarthropathies (SpA). We examined intra-rater and inter-rater ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0978-x
更新日期:2009-01-01 00:00:00
abstract::This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n=90) were included prospectively and followed up ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2569-3
更新日期:2014-06-01 00:00:00
abstract::Antibodies to 65Kd heat-shock protein (hsp) of mycobacterium leprae were measured by enzyme-linked immunosorbent assay (ELISA) in the three immunoglobulin classes in paired sera and synovial fluids of patients with rheumatoid arthritis (RA). Titers of anti-hsp antibody were expressed by optical density (OD) values for...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02249023
更新日期:1994-06-01 00:00:00
abstract::Brucellosis is a chronic infectious disease with articular involvement. Discrimination between brucellosis and rheumatologic disorders is difficult in regions endemic for brucellosis. There are few studies about the rate of positive autoantibodies as rheumatologic biomarkers in brucellosis, and the prevalence is varia...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3171-7
更新日期:2016-10-01 00:00:00
abstract::The aim of this study was to determine the serum interleukin-18 (IL-18) levels in patients with systemic lupus erythematosus (SLE) and to assess their relationship with disease activity. Thirty-five patients with SLE and 35 age- and sex-matched controls were enrolled in this study. Paired serum samples were collected ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0867-x
更新日期:2004-06-01 00:00:00
abstract::Iron-binding proteins (lactoferrin, transferrin and ferritin) and free iron were measured in synovial fluid (SF) from 30 patients with rheumatoid arthritis (RA) and 20 osteoarthritis (OA) patients. The iron-binding proteins except transferrin were significantly increased in RA SF as compared with OA SF. Similarly, fre...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030347
更新日期:1989-09-01 00:00:00