Abstract:
:Antibodies to beta(2)-glycoprotein I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). We investigated the sensitivity and specificity of ELISA for anti-beta(2)-GPI in Thai systemic lupus erythematosus (SLE) patients with clinical features of APS and compared the results with IgG/IgM aCL and LAC to find the test with the best association. The hospital records of 151 Thai SLE patients whose sera had been sent for either IgG/IgM anticardiolipin antibodies or lupus anticoagulant testing were reviewed. Sera of patients either without complete clinical records or those with APS-related manifestations other than vascular thrombosis and pregnancy morbidity (according to the international consensus statement on preliminary classification criteria for definite APS) were excluded. For the remaining subjects (112 patients), their sera were tested for anti-beta(2)-GPI antibody, IgG and IgM anticardiolipin, and lupus anticoagulant. The sensitivity and specificity of each method were compared by using the chi-square test. Among the 112 (74.2%) SLE patients in the study, 35 (31.3%) presented with preliminary clinical criteria for APS (i.e., vascular thrombosis and pregnancy morbidity) whereas 77 (68.7%) did not. The sensitivity and specificity of anti-beta(2)-GPI determination were 57.1 and 79.2%, respectively, whereas those of IgG aCL were 25.7 and 94.8%, of IgM aCL were 5.7 and 98.7%, and of LAC were 44.8 and 77.3%, respectively. The accuracy of the four tests showed similar association with clinical APS (accuracy of test = 72.3, 73.2, 69.6, and 68.3%, respectively). Concerning the sensitivity, specificity, and difficulty of the methods, the combination of anti-beta(2)-GPI and IgG aCL tests was the best for the diagnosis of APS in Thai SLE patients.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Parkpian V,Verasertniyom O,Vanichapuntu M,Totemchokchyakarn K,Nantiruj K,Pisitkul P,Angchaisuksiri P,Archararit N,Rachakom B,Ayurachai K,Janwityanujit Sdoi
10.1007/s10067-007-0566-5subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1663-70issue
10eissn
0770-3198issn
1434-9949journal_volume
26pub_type
杂志文章abstract::This study aims to identify the clinical predictors of arthritis in patients with psoriasis and to evaluate the use of musculoskeletal ultrasonography (US) as a predictor for inflammatory structural progression in psoriatic patients. Measures of association (odds ratio (OR)) were tested, in a prospective, cohort 1-yea...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2630-2
更新日期:2015-02-01 00:00:00
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journal_title:Clinical rheumatology
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doi:10.1007/s10067-008-1074-y
更新日期:2009-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2599-x
更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
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更新日期:2009-09-01 00:00:00
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更新日期:1996-03-01 00:00:00
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更新日期:2021-01-15 00:00:00
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更新日期:2018-02-01 00:00:00
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更新日期:2020-09-21 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-017-3606-9
更新日期:2017-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:2020-09-01 00:00:00
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1985-12-01 00:00:00