Abstract:
BACKGROUND:Clustering of autoimmune diseases is common and may be due to genetic background and exposition to environmental triggers. OBJECTIVE:The aim is to carry out a laboratory and clinical study of the prevalence of gastrointestinal organ-specific autoantibodies in rheumatoid arthritis (RA) patients and their relatives. METHODS:Serum samples of 156 RA patients, 200 relatives, and 100 healthy controls were studied for anti-smooth muscle antibody (ASMA), anti-mitochondrial (AMA), anti-parietal cell (APCA), anti-liver-kidney microsome (LKM), and anti-endomysium antibodies (IgA-EmA) by indirect immunofluorescence. RESULTS:A total of eight out of the 156 (5.1%) RA patients were positive for the autoantibodies (ASMA = 1; AMA = 2, APCA = 5). In the relative group, 12/200 (6%) had at least one positive autoantibody (ASMA = 1; AMA = 2, APCA = 7, IgA-EmA = 2). In the control group, two out of the 100 (2%) healthy controls were positive (ASMA = 1, APCA = 1). No statistical difference was found between RA patients, their relatives, and controls in relation to the frequency of autoantibodies evaluated. CONCLUSION:Although RA patients and their relatives have positivity of AMA, ASMA, and APCA without statistical difference in relation to healthy individuals, the findings may be of value for adequate clinical approach of these subjects.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Goeldner I,Skare TL,de Messias Reason IT,Nisihara RM,Silva MB,da Rosa Utiyama SRdoi
10.1007/s10067-010-1540-1subject
Has Abstractpub_date
2011-01-01 00:00:00pages
99-102issue
1eissn
0770-3198issn
1434-9949journal_volume
30pub_type
杂志文章abstract::The role of opioid therapy in chronic musculoskeletal disease continues to be controversial. However, recent years have seen a gradual shift towards the use of opioid therapy in chronic non-malignant pain (CNMP) following recognition that at least a subpopulation of such patients appears to benefit from long-term opio...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s100670200029
更新日期:2002-02-01 00:00:00
abstract::The aim of the study was to determine the main demographic, epidemiological, clinical characteristics, and outcome in patients with various types of brucellar monoarticular involvement. Retrospectively, we analyzed medical histories of 331 patients with brucellar monoarticular involvement who were treated at the infec...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3207-z
更新日期:2016-10-01 00:00:00
abstract::Ankylosing spondylitis (AS) is the prototype for spondyloarthritis primarily affecting young men. Geographic and ethnic variations exist in the prevalence and severity of AS and relate to the wide disparity in the frequency of human leukocyte antigen (HLA)-B27, a major genetic risk factor. The strength of the disease ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2058-5
更新日期:2012-11-01 00:00:00
abstract::We reported a case of dermatomyositis (DM) with liver disturbance in a 50-year-old Japanese female. She presented with fever, muscle weakness, and typical DM rashes. On clinical and serological examinations, the liver impairment was initially diagnosed as probable autoimmune hepatitis, which was denied by a histologic...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1397-3
更新日期:2010-08-01 00:00:00
abstract::We describe a case of an 82-year-old woman with giant cell arteritis, who developed unilateral pitting oedema of the dorsum of the right hand, foot and distal part of the right forearm as well as tenosynovitis of the right wrist extensors, mild synovitis of the right wrist, metacarpophalangeal and metatarsophalangeal ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050061
更新日期:1999-01-01 00:00:00
abstract::We reviewed three cases of systemic lupus erythematosus (SLE) in children with mesenteric vasculitis (LMV) as initial presentation and analysed their clinical characteristics to improve the understanding of this disease. Three patients with SLE were admitted to our hospital and initially presented with gastrointestina...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-017-3841-0
更新日期:2018-01-01 00:00:00
abstract::Ochronotic spondyloarthropathy is a rare metabolic disease with the musculoskeletal manifestations of alkaptonuria. Ochronotic arthropathy patients may have spinal abnormalities similar to ankylosing spondylitis (AS). The proof of sacroiliac involvement or bamboo spine appearance is not sufficient either for diagnosis...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0038-8
更新日期:2006-07-01 00:00:00
abstract::A case of polymyositis associated with scleroderma, adult coeliac disease, diabetes mellitus and IgA nephropathy is reported in a 33-year-old male. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031278
更新日期:1984-12-01 00:00:00
abstract::To study the clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia (AIRD-OP), the clinical presentation, radiological findings, treatment, and outcome of AIRD-OP patients were analyzed, in comparison with patients with cryptogenic organizing pneumonia (COP). A total of 131 OP patients w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3694-6
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:This study aims to analyze factors related to pregnancy outcomes in women with positive antiphospholipid antibodies and previous adverse pregnancy outcomes (APOs) prospectively. METHODS:Patients' characteristics were described. Factors associated with obstetric complications were analyzed using logistic regr...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05203-3
更新日期:2021-01-01 00:00:00
abstract::The aim of this study was to identify and evaluate laboratory parameters associated with normal bone mineral density (BMD) and to test if -308 tumour necrosis factor (TNF) alpha gene promoter polymorphisms could influence BMD. We performed a comparative cross-sectional study of four main groups: young healthy individu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0706-y
更新日期:2008-03-01 00:00:00
abstract::The aim of this study was to investigate the clinical features, risk factors, and outcomes of septic arthritis in patients on maintenance hemodialysis (HD). We systematically reviewed medical records of 16 HD patients with septic arthritis admitted to our hospital from April 2008 to April 2018. A total of 16 HD in pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05114-3
更新日期:2020-10-01 00:00:00
abstract::The effect of niflumic acid on hyaluronic acid and proteoglycan metabolism of human cartilage cells was investigated in vitro. Cartilage cells were obtained from five different donors. Niflumic acid levels used in the test systems ranged from 0 to 22 microgramsr/ml and were comparable to serum concentrations in humans...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030238
更新日期:1990-03-01 00:00:00
abstract::This study was designed to investigate the functional heterogeneity of human Th17 and how their plasticity shapes the nature of immune cell responses to inflammation and autoimmune diseases, such as systemic lupus erythematosus (SLE). We evaluated functional Th17 cell subsets based on the profile of cytokine productio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1860-9
更新日期:2012-03-01 00:00:00
abstract::We encountered only three patients of carpal tunnel syndrome (CTS) due to tophaceous gout during 25 years of practice in a 'hand clinic' situated in a large metropolis in West India. In two patients, the CTS was bilateral, a rare occurrence in gout. There was an unwarranted delay (up to 9 years) in the diagnosis of bo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0672-4
更新日期:2007-12-01 00:00:00
abstract::This study aims to measure the frequency of medication error (ME) in rheumatology outpatients of the Social Security System (SS) in Mexico and to measure the costs by comparing the days lost at work as direct consequence of the medication error against the theoretical cost of no error in the process. A prospective 6-m...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1837-8
更新日期:2011-11-01 00:00:00
abstract::Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloido...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-004-1076-3
更新日期:2006-02-01 00:00:00
abstract::Upper lobe fibrobullous disease is a well-known finding in advanced stages of ankylosing spondylitis (AS). In this report, we present a 57-year-old male patient who was diagnosed with a right apical cavitary lesion after coming to us with the complaint of haemoptysis. The patient underwent upper lobe segmentectomy and...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-004-1047-8
更新日期:2005-08-01 00:00:00
abstract::There are few reports about the coexistence of Sjögren's syndrome (SS) and ankylosing spondylitis (AS). To evaluate the frequency of SS in patients with AS. We studied 70 patients with AS presenting to the university outpatient clinic between January 2002 and November 2003. All the patients were asked about sicca symp...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0255-9
更新日期:2007-02-01 00:00:00
abstract::We describe four cases of giant cell arteritis (GCA) that presented with occipital headache in the last 6 months. Typical ultrasound features of GCA were found in the occipital arteries which helped to confirm the diagnosis. One patient had already suffered significant visual loss by the time the diagnosis was made, r...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-017-3946-5
更新日期:2018-02-01 00:00:00
abstract::Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4010-9
更新日期:2018-10-01 00:00:00
abstract::Over the last decade, biologic therapeutic proteins have advanced the treatment of diseases such as rheumatoid arthritis (RA). Therapeutic antibodies such as infliximab, adalimumab, rituximab, tocilizumab, golimumab, certolizumab pegol, the receptor construct etanercept, and abatacept, an anticluster of differentiatio...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2040-2
更新日期:2012-09-01 00:00:00
abstract::Employing a recently developed questionnaire we studied the self-esteem structure of 61 female fibromyalgia (FM) patients by comparing them with i) 40 healthy psychology students and ii) 37 patients suffering from rheumatoid arthritis. Depressed FM patients (n=36) had a high need to gain self-esteem through competence...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02247798
更新日期:1997-11-01 00:00:00
abstract::The objective of this study is to identify the clinical differences between infectious meningitis and neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with SLE. Clinical manifestations, laboratory test results, and prognoses of 14 SLE patients complicated with various infectious meningitis, hospitaliz...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2726-8
更新日期:2015-02-01 00:00:00
abstract::We report a case of hypokalaemic, flaccid quadriparesis with sudden respiratory arrest in a 27-year-old Japanese woman in whom the discovery of distal renal tubular acidosis led to the diagnosis of primary Sjögren's syndrome (SS). Hypokalaemic periodic paralysis as the initial manifestation of primary SS is rare, but ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170028
更新日期:2001-01-01 00:00:00
abstract::Treatment with methotrexate (MTX) is well established in rheumatoid arthritis (RA), but dosing remains arbitrary as studies on the effect of different dosing schedules are lacking. In a randomised crossover design of 20 patients with RA, the effect of low (2.5mg) oral daily doses of MTX (15 mg weekly) was compared to ...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02231528
更新日期:1993-06-01 00:00:00
abstract::Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is characterized by recurrent episodes of inflammation with fever, abdominal pain, chest pain, rash, myalgia, arthralgia, conjunctivitis, and periorbital edema. This condition is a rare autosomal dominant disease that is strongly associated with heter...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-018-4023-4
更新日期:2018-05-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF-alpha) plays an important role in the pathogenesis of chronic inflammatory diseases, i.e., rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD), and ulcerative colitis (UC). Anti-TNF-alpha strategies are successfully used in their treatment. However, their effec...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2091-4
更新日期:2013-01-01 00:00:00
abstract::The original version of this article was revised due to a retrospective Open Access order. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-020-05278-y
更新日期:2020-10-01 00:00:00
abstract::Sudden death following steroid pulse therapy has been recently reported. Continuous electrocardiographic recording was performed 24 hours before, during, and 24 hours after each one to three high dose intravenous methyl prednisolone pulses administered of five patients with severe ankylosing spondylitis unresponsive t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02715692
更新日期:1984-03-01 00:00:00