Abstract:
:This study was designed to investigate the functional heterogeneity of human Th17 and how their plasticity shapes the nature of immune cell responses to inflammation and autoimmune diseases, such as systemic lupus erythematosus (SLE). We evaluated functional Th17 cell subsets based on the profile of cytokine production in peripheral blood (PB), bone marrow aspirates (BM) and lymph node biopsies (LN) from healthy individuals (n = 35) and PB from SLE patients (n = 34). Data were analysed by an automated method for merging and calculation of flow cytometric data, allowing us to identify eight Th17 subpopulations. Normal BM presented lower frequencies of Th17 (p = 0.006 and p = 0.05) and lower amount of IL-17 per cell (p = 0.03 and p = 0.02), compared to normal PB and LN biopsies. In the latter tissues were found increased proportions of Th17 producing TNF-α or TNF-α/IL-2 or IFN-γ/TNF-α/IL-2, while in BM, Th17 producing other cytokines than IL-17 was clearly decreased. In SLE patients, the frequency of Th17 was higher than in control, but the levels of IL-17 per cell were significantly reduced (p < 0.05). Among the eight generated subpopulations, despite the great functional heterogeneity of Th17 in SLE, a significant low proportion of Th17 producing TNF-α was found in inactive SLE, while active SLE showed a high proportion producing only IL-17. Our findings support the idea that the functional heterogeneity of Th17 cells could depend on the cytokine microenvironment, which is distinct in normal BM as well as in active SLE, probably due to a Th1/Th2 imbalance previously reported by our group.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Henriques A,Inês L,Pais ML,da Silva JA,Paiva AAdoi
10.1007/s10067-011-1860-9subject
Has Abstractpub_date
2012-03-01 00:00:00pages
483-91issue
3eissn
0770-3198issn
1434-9949journal_volume
31pub_type
杂志文章abstract:INTRODUCTION:We investigated whether rheumatoid arthritis (RA)-related autoantibodies were associated with abnormalities on pulmonary function tests (PFTs). METHODS:We studied RA serostatus and PFT abnormalities within a RA registry. RA serostatus was assessed by research assays for cyclic citrullinated peptide (CCP) ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04733-9
更新日期:2019-12-01 00:00:00
abstract::Sjõgren's disease is one of the most common rheumatological diseases and can present with a variety of extra-glandular manifestations. Lymphocytic Interstitial Pneumonitis (LIP) is the most common lung pathology in these patients. It is important to know and recognize this condition because it is potentially treatable...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-006-0351-x
更新日期:2007-08-01 00:00:00
abstract:INTRODUCTION:Alkaptonuria (AKU) is a rare metabolic disease. The global incidence is 1:100,000 to 1:250,000. However, identification of a founder mutation in a gypsy population from India prompted us to study the prevalence of AKU in this population and to do molecular typing in referred cases of AKU from the rest of I...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05020-8
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Rheumatoid arthritis (RA) may increase the risk of anxiety, but results from prior studies have no consensus. Our study aimed to evaluate the relationship between RA and incident anxiety by using a quantitative meta-analysis. METHODS:A number of databases were used to gather relevant information; they inclu...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-019-04502-8
更新日期:2019-08-01 00:00:00
abstract::The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 month...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3911-3
更新日期:2018-02-01 00:00:00
abstract::We describe the case of a 26-year-old African female who was treated successfully with belimumab in a case of severe membranous lupus nephritis and retinal vasculitis, resistant to first line therapy. She presented initially with chronic dacryoadenitis and screening showed nephrotic-range proteinuria. Biopsy of the ki...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3153-1
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To determine the serum levels of Dickkopf-1 (DKK-1) and sclerostin, as well as their correlations with the structural damage assessed by modified stoke ankylosing spondylitis spine score (mSASSS) and the disease activity evaluated by ankylosing spondylitis disease activity score (ASDAS) in patients with ankyl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4356-z
更新日期:2019-04-01 00:00:00
abstract::Small differences in inbred animals with a gene for arthritis must be the cause that some of them evolve the disease and others not. These differences are partly stochastic, caused by thermal movement of molecules. It is possible that their effect is amplified by a network of cytokines, known to play an important role...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF03342643
更新日期:1996-01-01 00:00:00
abstract::The authors wish to acknowledge that whilst this study and that published in Hammad et al [1] explore different areas - blood cell ratios and serum endocan, respectively - the reader may identify some similarities between the papers owing to the same patient cohort being analysed in both studies. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-019-04583-5
更新日期:2019-07-01 00:00:00
abstract::In 1960 Rabinowitz and Dameshek emphasized the close relationship between idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) and suggested that ITP is often a prodrome of SLE. On the basis of tis observation, the present study was designed to investigate the prevalence of SLE in patients ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041395
更新日期:1983-09-01 00:00:00
abstract:OBJECTIVES:Action potential simulation (APS) is becoming a popular method of pain reduction. Nevertheless, little is known about the efficacy of this relatively new treatment. The aim of this study was to investigate whether APS helps to reduce pain, improves patients' perception of daily functioning and social partici...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-006-0297-z
更新日期:2007-03-01 00:00:00
abstract::Neurological involvement is uncommon in systemic sclerosis. Most of the reported cases concern trigeminal neuropathy or peripheral nerve entrapment. We report a third case of brachial plexopathy, presumably related to vasculitis, in a patient with systemic sclerosis, which improved after cyclophosphamide therapy. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200106
更新日期:2002-09-01 00:00:00
abstract::Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and subcutaneous sites. In recent years, with the continuous research on gout animal models and patient clinical investigations, the mechanism of i...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05090-8
更新日期:2020-10-01 00:00:00
abstract::Juvenile dermatomyositis (JDM) is a rare chronic inflammatory disease of unknown etiology and primarily involves muscle and skin. It is the most common idiopathic inflammatory myopathy of childhood. This study aimed to evaluate demographic and clinical features, laboratory data, treatment modalities, and outcome of pa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3530-4
更新日期:2017-02-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multi-system chronic inflammatory disease with a broad spectrum of clinical and serological manifestations. Although clinical evidence of proximal skeletal muscle involvement is not rare in patients with SLE, there is no knowledge about the effects of SLE on the macroscopic stru...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2249-8
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:We hypothesized that mechanical compression of the knee in rheumatoid arthritis (RA) would mobilize occult extractable fluid and improve arthrocentesis success. METHODS:Sixty-seven consecutive knees with RA and 186 knees with OA and were included. Conventional arthrocentesis was performed and s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04524-2
更新日期:2019-08-01 00:00:00
abstract::Caeruloplasmin (Cp), prealbumin and alpha 2-macroglobulin (alpha 2-M) concentrations in serum were compared in rheumatoid arthritis (RA), osteoarthrosis, ankylosing spondylitis, psoriatic arthritis, Reiter's syndrome, Behçet's syndrome, SLE and normal controls. Cp was significantly elevated (p less than 0.01) in all d...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02201003
更新日期:1987-03-01 00:00:00
abstract::The aim of this study is to assess the gender differences in spondyloarthritides (SpAs) in terms of disease onset, clinical presentation, and the Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI). We analysed data from a predominantly female cohort. Five hundred and 16 patients (ma...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1581-5
更新日期:2011-01-01 00:00:00
abstract::We report a 29-year-old Japanese woman with disseminated intravascular coagulation (DIC) and adult onset Still's disease (AOSD). Her disease was refractory to high-dose glucocorticoids, two courses of steroid pulse therapy, and addition of cyclosporine (3.5 mg/kg/day). The serum interleukin-6 level was markedly elevat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1097-z
更新日期:2009-04-01 00:00:00
abstract::Hyperimmunoglobulinemia D syndrome (HIDS) is newly recognized and resembles familial Mediterranean fever (FMF). It is inherited as an autosomal recessive trait. Mutation of the gene coding for mevalonate kinase is responsible for the disease. The gene is located at chromosome 12q24. The patients initially described we...
journal_title:Clinical rheumatology
pub_type: 信件
doi:10.1007/s10067-004-0953-0
更新日期:2005-02-01 00:00:00
abstract::It has been well established that, anti-thyroglobulin antibodies (ATG) and anti-microsomal antibodies (AMC) may be present in various thyroid disorders and other systemic autoimmune diseases, including Sjögren's syndrome (SS). However, presence of circulating autoantibodies to thyroid hormones, i.e. both to triiodothy...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170102
更新日期:2001-01-01 00:00:00
abstract::Kidney involvement in immuno-mediated diseases is a life threatening complication to be early detected. Glomerulo-tubular functional indices, kidney-released enzymes and metabolic profiles were assessed in 21 patients with systemic lupus erythematosus, progressive systemic sclerosis and mixed cryoglobulinaemia, withou...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231679
更新日期:1996-01-01 00:00:00
abstract::Anaesthesia in patients with either treated or untreated osteo-articular disorders poses a number of specific problems. The authors deal with risks resulting from mechanical deformities produced by these disorders, by the involvement of a large number of functional systems, by changes in the immune status of such pati...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02032315
更新日期:1985-03-01 00:00:00
abstract::The objective of this study was to determine tendon involvements and enthesal abnormalities in patients with rheumatoid arthritis (RA) using high-resolution ultrasonographic images and to compare the findings with those seen in patients with ankylosing spondylitis (AS) and healthy controls. A total of 24 patients with...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0997-1
更新日期:2005-06-01 00:00:00
abstract::The aim of this study was to investigate the involvement of autonomic nervous system (ANS) function by using power spectral analysis of heart rate variability (HRV) method in patients with ankylosing spondylitis (AS). The study included 94 AS patients all fulfilling the New York criteria for AS, and 49 healthy volunte...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/pl00011198
更新日期:2001-01-01 00:00:00
abstract::Behcet's disease (BD) is a systemic vasculitis characterized by genital and oral ulcers, uveitis, and other organs' involvement. Left ventricular (LV) diastolic dysfunction has been documented in BD. However, conventional echocardiographic techniques have serious limitations like its dependence on preload, afterload a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0208-3
更新日期:2006-11-01 00:00:00
abstract::Eighteen patients (nine girls, nine boys) with systemic onset juvenile rheumatoid arthritis (SO-JRA) treated with methotrexate (MTX) for a mean period of 18 months (range 6-41 months) were analysed to evaluate the safety and efficacy of MTX in this disease subtype. The MTX dose ranged from 2.5 to 15 mg/week with a mea...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01450959
更新日期:1998-01-01 00:00:00
abstract::We compared the short-term effects of Stanger bath therapy and conventional exercises on spinal mobility, functional capacity, disease activity, and quality of life with conventional exercise alone in ankylosing spondylitis (AS) patients. A total of 58 patients with a diagnosis of AS according to the modified New York...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-008-0873-5
更新日期:2008-07-01 00:00:00
abstract::The aim of our study was to explore the relationship between circulating T cells and ankylosing spondylitis (AS) and to find the role of the CD8+CD122+ T cells in the pathogenesis and progression of AS. With the method of case-control design, flow cytometry was performed to quantitatively determine the percentage of c...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3887-z
更新日期:2018-03-01 00:00:00
abstract::Immunoglobulins are often high in active rheumatoid arthritis and fall when treatment with a slow-acting anti-rheumatic drug is instituted. We assessed the value of monitoring immunoglobulins during penicillamine therapy; 145 patients were followed for up to 5 years, IgA, IgM and IgG levels were compared to 12 other c...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02239191
更新日期:1988-09-01 00:00:00