Rate and causes of noncompliance with disease-modifying antirheumatic drug regimens in patients with rheumatoid arthritis.

Abstract:

INTRODUCTION/OBJECTIVES:To determine the prevalence and factors associated with medication noncompliance by Thai patients with rheumatoid arthritis (RA). METHODS:This prospective cohort study enrolled 443 adult RA patients (≥ 18 years) who were followed up at the outpatient rheumatology clinics of Siriraj Hospital and Phramongkutklao Hospital between May 2018 and December 2019. Medication noncompliance was assessed using the Compliance Questionnaire for Rheumatology-19 (CQR-19). A score of 0 indicated complete noncompliance, whereas a score of 100 indicated a perfect compliance. An unsatisfactory compliance was arbitrarily defined as a taking compliance of ≤ 80%. RESULTS:The prevalence of medication noncompliance was 22.1%. The most common cause was forgetting to take medications due to a busy work schedule. In a univariate analysis, the factors that were significantly related to medication noncompliance were age, income, number of comorbidities, functional status as measured by the Health Assessment Questionnaire (HAQ), number of prescribed pills per day, and number of types of prescribed medications per day. In a subsequent backward stepwise multiple logistic regression analysis, only 2 factors were found to be negatively associated with medication noncompliance: age (risk ratio, 0.98; 95% CI, 0.96-0.99; p, 0.048) and HAQ (risk ratio, 0.62; 95% CI, 0.39-0.98; p, 0.041). CONCLUSIONS:Medication noncompliance is common in patients with RA. As this may lead to unfavorable outcomes, patient education related to drug compliance should be addressed and emphasized in daily practice. Key Points • Medication noncompliance is common in patients with RA. • Forgetting to take pills was the most frequent explanation offered for noncompliance. • All patients should be strongly encouraged to comply with the recommended drug regimens.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Katchamart W,Narongroeknawin P,Sukprasert N,Chanapai W,Srisomnuek A

doi

10.1007/s10067-020-05409-5

subject

Has Abstract

pub_date

2020-09-21 00:00:00

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-020-05409-5

pub_type

杂志文章
  • Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.

    abstract::We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine sampl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0632-z

    authors: Otukesh H,Chalian M,Hoseini R,Chalian H,Hooman N,Bedayat A,Yazdi RS,Sabaghi S,Mahdavi S

    更新日期:2007-12-01 00:00:00

  • The associations of phase angle with the structural severity and quadriceps strength among patients with hip osteoarthritis: the SPSS-OK study.

    abstract:INTRODUCTION/OBJECTIVES:This study examined whether phase angle (PhA) is associated with hip osteoarthritis (HOA) severity and quadriceps strength in patients with HOA. METHOD:A series of 549 patients with HOA, obtained from the Screening for People Suffering Sarcopenia in the Orthopedic cohort of Kobe study, were ana...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05419-3

    authors: Wada O,Yamada M,Kamitani T,Mizuno K,Kurita N

    更新日期:2020-09-29 00:00:00

  • Colonic transit disorders in systemic sclerosis.

    abstract::Systemic sclerosis (SS) alters smooth muscle function throughout the gastrointestinal tract, the oesophagus being the segment most often involved. Involvement of the colon, though less common, may lead to life-threatening complications. We studied 23 unselected patients with SS and 20 age-matched healthy controls usin...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s100670170038

    authors: Wang SJ,Lan JL,Chen DY,Chen YH,Hsieh TY,Lin WY

    更新日期:2001-01-01 00:00:00

  • Frequency and spectrum of outpatient musculoskeletal diagnoses at a pediatric hospital in Kenya.

    abstract::Chronic pediatric musculoskeletal (MSK) conditions are a major cause of morbidity. The burden of pediatric rheumatic diseases in East Africa is largely unknown. The purposes of this study were to estimate frequencies and assess the spectrum of MSK-related diagnoses using ICD-10 diagnostic codes among outpatients at a ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4376-8

    authors: Scuccimarri R,Broten L,Migowa A,Ngwiri T,Wachira J,Bernatsky S,Hitchon C,Colmegna I

    更新日期:2019-04-01 00:00:00

  • Effect of delayed diagnosis on disease course and management of Churg-Strauss syndrome: a retrospective study.

    abstract::Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2127-9

    authors: Sokołowska B,Szczeklik W,Mastalerz L,Kuczia P,Wodkowski M,Stodółkiewicz E,Macioł K,Musiał J

    更新日期:2013-03-01 00:00:00

  • From scleredema to AL amyloidosis: disease progression or coincidence? Review of the literature.

    abstract::Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloido...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-004-1076-3

    authors: Dziadzio M,Anastassiades CP,Hawkins PN,Potter M,Gabrielli A,Brough GM,Black CM,Denton CP

    更新日期:2006-02-01 00:00:00

  • Case reports: testicular pain as a manifestation of polyarteritis nodosa.

    abstract::Polyarteritis nodosa (PAN) is a necrotising vasculitis of medium-sized vessels of unknown origin. This type of vasculitis is usually systemic, but restriction to a single organ, for example the testis, the appendix or the gall bladder, can occur. Testicular pain or tenderness are frequent clinical features. In this re...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-0970-5

    authors: Meeuwissen J,Maertens J,Verbeken E,Blockmans D

    更新日期:2008-11-01 00:00:00

  • Immunoscintigraphy as an adjunct to diagnostic imaging in septic sacroiliitis. Report of a case.

    abstract::Septic sacroiliitis in childhood is a relatively rare condition. We describe a case of septic sacroiliitis occurring in an 11-year-old girl in whom the diagnosis was suspected on clinical findings and bone scan. Immunoscintigraphy with 99mTc-labelled antigranulocyte antibodies further supported the hypothesis for a se...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02231689

    authors: Rambaldi PF,Ambrosone L,Mansi L,Torino G,Del Vecchio E,Rambaldi M

    更新日期:1996-01-01 00:00:00

  • One-year efficacy and safety of single or one to three weekly injections of hylan G-F 20 for knee osteoarthritis: a systematic literature review and meta-analysis.

    abstract::The aim of this study was to evaluate the long-term efficacy and safety of single or 1-3 weekly injections of hylan G-F 20 at 1 year following the first injection for knee osteoarthritis (OA). Searches were conducted in PubMed/MEDLINE, Embase, and CENTRAL and included relevant conference proceedings (January 1, 1995-A...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-020-05477-7

    authors: De Lucia O,Jerosch J,Yoon S,Sayre T,Ngai W,Filippou G

    更新日期:2020-10-27 00:00:00

  • Chloroquine therapy in patients with recent-onset rheumatoid arthritis: the clinical response can be predicted by the low level of acute-phase reaction at baseline.

    abstract::If rheumatoid arthritis (RA) patients with a mild disease course could be identified early in the phase of the disease, therapy with less aggressive and probably less toxic antirheumatic drugs seems to be rational. The aim of this study was to investigate which factors at baseline could predict a clinical response (Am...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s100670050121

    authors: van den Borne BE,Landewé RB,Rietveld JH,Goei The HS,Griep EN,Breedveld FC,Dijkmans BA

    更新日期:1999-01-01 00:00:00

  • Prolactinoma and systemic lupus erythematosus: do serum prolactin levels matter?

    abstract::The lactogenic hormone prolactin is produced in part by cells of the immune system and serves as an upregulator of immune function. Hyperprolactinemia is common in patients with systemic lupus erythematosus (SLE), raising the possibility that the hormone contributes to the excessive immune response in the disease. The...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0117-x

    authors: Li M,Keiser HD,Peeva E

    更新日期:2006-07-01 00:00:00

  • Clinical features associated with pregnancy outcomes in women with positive antiphospholipid antibodies and previous adverse pregnancy outcomes: a real-world prospective study.

    abstract:OBJECTIVE:This study aims to analyze factors related to pregnancy outcomes in women with positive antiphospholipid antibodies and previous adverse pregnancy outcomes (APOs) prospectively. METHODS:Patients' characteristics were described. Factors associated with obstetric complications were analyzed using logistic regr...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05203-3

    authors: Li X,Deng X,Duan H,Zeng L,Zhou J,Liu C,Guo X,Liu X

    更新日期:2021-01-01 00:00:00

  • The detection of calcium pyrophosphate crystals in sequential synovial fluid examinations of patients with osteoarthritis: once positive, always positive.

    abstract::The aim of this study was to investigate whether calcium pyrophosphate dihydrate (CPPD) crystals are constantly detectable in sequential synovial fluid (SF) examinations of patients with initially CPPD-positive osteoarthritis (OA). For this purpose, we searched our SF database for CPPD-positive patients, who had two o...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2147-5

    authors: Robier C,Neubauer M,Fritz K,Lippitz P,Stettin M,Rainer F

    更新日期:2013-05-01 00:00:00

  • Insulin and new bone formation in diffuse idiopathic skeletal hyperostosis.

    abstract::The tendency of patients with DISH towards obesity or an adult onset of diabetes has been reflected in marked hyperinsulinaemia following glucose challenge. It is hypothesized that insulin at prolonged and high physiologic levels promotes new bone growth, particularly in the entheseal regions. These areas are also sub...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031611

    authors: Littlejohn GO

    更新日期:1985-09-01 00:00:00

  • Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis.

    abstract::Antibodies to 65Kd heat-shock protein (hsp) of mycobacterium leprae were measured by enzyme-linked immunosorbent assay (ELISA) in the three immunoglobulin classes in paired sera and synovial fluids of patients with rheumatoid arthritis (RA). Titers of anti-hsp antibody were expressed by optical density (OD) values for...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02249023

    authors: Oda A,Miyata M,Kodama E,Satoh H,Sato Y,Nishimaki T,Nomaguchi H,Kasukawa R

    更新日期:1994-06-01 00:00:00

  • What do Australian patients with inflammatory arthritis value in treatment? A discrete choice experiment.

    abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to develop an understanding of treatment preferences in patients with inflammatory arthritis (IA) [rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)] focussing on treatment attributes that patients' value, their relative importan...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04843-4

    authors: Ho KA,Acar M,Puig A,Hutas G,Fifer S

    更新日期:2020-04-01 00:00:00

  • Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice.

    abstract::Severe exacerbation of symptoms following physical activity is characteristic for chronic-fatigue syndrome (CFS) and fibromyalgia (FM). These exacerbations make it understandable for people with CFS and FM to develop fear of performing body movement or physical activity and consequently avoidance behaviour toward phys...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-013-2277-4

    authors: Nijs J,Roussel N,Van Oosterwijck J,De Kooning M,Ickmans K,Struyf F,Meeus M,Lundberg M

    更新日期:2013-08-01 00:00:00

  • Evaluation of left ventricular diastolic dysfunction with conventional and current Doppler techniques in Behcet's disease.

    abstract::Behcet's disease (BD) is a systemic vasculitis characterized by genital and oral ulcers, uveitis, and other organs' involvement. Left ventricular (LV) diastolic dysfunction has been documented in BD. However, conventional echocardiographic techniques have serious limitations like its dependence on preload, afterload a...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0208-3

    authors: Baris N,Okan T,Gurler O,Akdeniz B,Turker S,Ilknur T,Akkoc N,Goldeli O

    更新日期:2006-11-01 00:00:00

  • Prevalence of cardiovascular risk factors in patients with psoriatic arthritis.

    abstract::Psoriatic arthritis (PsA) is a chronic T cell-mediated inflammatory spondyloarthropathy affecting 10-40 % of psoriasis (PSO) patients (0.3-1.0 % of the general population). Recent epidemiological studies have shown an increased prevalence of cardiovascular (CV) risk factors and/or morbidity among PSO or PsA patients a...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2743-7

    authors: Khraishi M,Aslanov R,Rampakakis E,Pollock C,Sampalis JS

    更新日期:2014-01-01 00:00:00

  • Bone mass in Zaireans: radiogrammetric determination.

    abstract::Bone mass was measured in 230 subjects with ages ranging from 15 to 54 years (110 males and 120 females), using the radiogrammetric method on the second metacarpal bone. Results of the study show that bone mass increases with age up to 34 years and then decreases, both in males and females, although males have signifi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02208090

    authors: Kabeya JM,Mbuyi Muamba JM,Tozin R,Dequeker J

    更新日期:1995-01-01 00:00:00

  • Comorbidity of gout and rheumatoid arthritis in a large population database.

    abstract::Coexistence of rheumatoid arthritis and gout is considered to be unusual. The current study was designed as a population-based cross-sectional study, utilizing the medical database of Clalit Health Services, the largest healthcare provider organization in Israel. Data of adult patients who were previously diagnosed wi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3477-5

    authors: Merdler-Rabinowicz R,Tiosano S,Comaneshter D,Cohen AD,Amital H

    更新日期:2017-03-01 00:00:00

  • Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues.

    abstract::This study was designed to investigate the functional heterogeneity of human Th17 and how their plasticity shapes the nature of immune cell responses to inflammation and autoimmune diseases, such as systemic lupus erythematosus (SLE). We evaluated functional Th17 cell subsets based on the profile of cytokine productio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1860-9

    authors: Henriques A,Inês L,Pais ML,da Silva JA,Paiva AA

    更新日期:2012-03-01 00:00:00

  • Erythema nodosum and Hodgkin's disease.

    abstract::Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02114402

    authors: Taillan B,Ferrari E,Fuzibet JG,Vinti H,Pesce A,Dujardin P

    更新日期:1990-09-01 00:00:00

  • Clinical course and outcomes of COVID-19 in rheumatic disease patients: a case cohort study with a diverse population.

    abstract:OBJECTIVE:To determine clinical course and outcomes in rheumatic disease patients with coronavirus disease 2019 (COVID-19) and compare results to uninfected patients. METHODS:We conducted a case cohort study of autoimmune disease patients with COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR)...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-021-05578-x

    authors: Arleo T,Tong D,Shabto J,O'Keefe G,Khosroshahi A

    更新日期:2021-01-09 00:00:00

  • Non-canonical manifestations of familial Mediterranean fever: a changing paradigm.

    abstract::Paroxysmal crises of fever and systemic inflammation herald familial Mediterranean fever (FMF), considered as the archetype of all inherited systemic autoinflammatory diseases. Inflammatory bouts are characterized by short-term and self-limited abdominal, thoracic, and/or articular symptoms which subside spontaneously...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-015-2916-z

    authors: Rigante D,Lopalco G,Tarantino G,Compagnone A,Fastiggi M,Cantarini L

    更新日期:2015-09-01 00:00:00

  • Chagas disease reactivation in rheumatologic patients: association with immunosuppressive therapy and humoral response.

    abstract::Evidence for Chagas disease reactivation (CDR) in rheumatologic patients under rheumatologic treatments (RTs) is scarce. To screen and follow-up patients with rheumatic diseases and concomitant Chagas disease under RT to detect CDR and to describe a possible relationship between CDR and specific RT. An observational, ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-021-05581-2

    authors: Ringer A,Ruffino JP,Leiva R,Cuadranti N,Argento MC,Martínez MF,Rolla I,Chulibert S,Carbone D,Palatnik M,Cortese MN,Lagrutta M,Córdoba L,González FB,Pacini MF,Villar SR,Águila D,Bottasso OA,Pérez AR,Abdala M

    更新日期:2021-01-12 00:00:00

  • Clinical spectrums and outcomes of necrotizing autoimmune myopathy versus other idiopathic inflammatory myopathies: a multicenter case-control study.

    abstract:OBJECTIVE:To investigate the clinical characteristics, laboratory features, and treatment outcomes of Thai patients compared between those with necrotizing autoimmune myopathy (NAM) and those with other idiopathic inflammatory myopathies (IIMs) or non-NAM. METHODS:This multicenter case-control study included patients ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10067-019-04756-2

    authors: Yongchairat K,Tanboon J,Waisayarat J,Narongroeknawin P,Chevaisrakul P,Dejthevaporn C,Katchamart W

    更新日期:2019-12-01 00:00:00

  • Involvement of atlanto-axial joint in rheumatoid arthritis: rare or frequent?

    abstract::The authors studied the incidence of atlanto-axial joint involvement by conventional radiography and CT in 183 patients with classical or definite rheumatoid arthritis (RA). In determining lesions the significance of factors such as age, sex, duration and severity of the disease was evaluated. Atlanto-axial subluxatio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02242943

    authors: Montemerani M,Venturi C,Bracco S,Coviello G,Minari C,Fioravanti A,Marcolongo R

    更新日期:1994-09-01 00:00:00

  • Septic arthritis due to bacteroides fragilis after pilonidal sinus resection in a patient with rheumatoid arthritis.

    abstract::Bacteroides fragilis is a rare cause of septic arthritis. Most patients with B. fragilis septic arthritis have a chronic joint disease, particularly rheumatoid arthritis, and sources of infection are lesions of the gastrointestinal tract and the skin. We report a 69-year-old male, who developed B. fragilis septic arth...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02247808

    authors: Borer A,Weber G,Riesenberg K,Schlaeffer F,Horowitz J

    更新日期:1997-11-01 00:00:00

  • Volume of a wash and the other conditions for maximum therapeutic effect of arthroscopic lavage in rheumatoid knees.

    abstract::The objective of this study was to determine the appropriate volume of saline to obtain a beneficial effect of arthroscopic lavage and the prognostic factors related to the clinical effect in a refractory rheumatoid knee. Arthroscopic lavage or arthrocentesis was performed in a random manner in 142 patients with relap...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10067-005-1143-4

    authors: Tanaka N,Sakahashi H,Hirose K,Ishima T,Ishii S

    更新日期:2006-02-01 00:00:00