Abstract:
:Rituximab is a human/murine chimeric anti-CD20 monoclonal antibody. It is largely used to treat B cell malignancies and has become standard in the management of B cell‑mediated diseases such as rheumatoid arthritis and granulomatosis with polyangitis. The effects of rituximab need to be monitored by B cell phenotyping. Evaluate possible surface markers for monitoring B cell development in response to rituximab treatment. This review discusses the literature on the B cell surface markers analysed by flow cytometry in patients treated with rituximab. A panel of biomarkers of response to treatment to monitor by flow cytometry is also suggested. B cell phenotyping is useful to predict clinical relapses after rituximab treatment. The proposed panel of biomarkers includes CD38++CD24++IgD+/- immature B cells and IgD-CD38+/- memory B cells. In responders, Th1/Th2 balance and tolerance cells (CD4+CD25+CD127-/low Treg cells and CD19+CD24hiCD38hi Breg cells) tend to be restored after rituximab therapy. Furthermore, in responder patients, indirect depletion of CD19+/-CD27++CD38++ preplasma cells can be proposed as a predictor of response. Flow cytometric analysis of samples from patients treated with rituximab is a useful strategy to stratify patients according to response to treatment. Identification of B cell differentiation stages by means of a specific flow cytometry panel could improve monitoring of rituximab effects and enable non-responders to be distinguished from good responders.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Bergantini L,d'Alessandro M,Cameli P,Vietri L,Vagaggini C,Perrone A,Sestini P,Frediani B,Bargagli Edoi
10.1007/s10067-020-04996-7subject
Has Abstractpub_date
2020-05-01 00:00:00pages
1415-1421issue
5eissn
0770-3198issn
1434-9949pii
10.1007/s10067-020-04996-7journal_volume
39pub_type
杂志文章,评审abstract::A cohort of patients with recently diagnosed axial spondyloarthritis (SpA) was characterized with emphasis on gender differences and factors leading to delay in diagnosis. Clinical, laboratory, and imaging data of 151 consecutive patients diagnosed with ankylosing spondylitis or undifferentiated SpA in 2004-2009 and s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1719-0
更新日期:2011-08-01 00:00:00
abstract::This study aims to develop a sandwich ELISA system for the measurement of soluble folate receptor β (sFRβ) and evaluate whether base line levels of serum sFRβ are a biomarker for the activity of RA synovitis and the response to anti-TNF agents. Serum sFRβ from normal controls (41 samples), patients with OA (29 samples...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4202-3
更新日期:2018-11-01 00:00:00
abstract::Disease-modifying antirheumatic biological and non-biological therapies are associated with reduced disease progression and joint destruction. Suggestions have been made that total knee and hip joint arthroplasty indications are decreasing as a beneficial effect of the new forms of therapy for rheumatoid arthritis. We...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1629-6
更新日期:2011-04-01 00:00:00
abstract::Pain is a leading cause of morbidity worldwide, with published data showing its prevalence as high as 50% for chronic pain in the European population. This prevalence is likely to continue to rise, particularly in elderly people with comorbid conditions and complex aetiologies of pain. There is thus a rapidly growing ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-006-0311-5
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of the commonly used urate-lowering therapies (ULTs): febuxostat, allopurinol, and lesinurad in hyperuricemic patients with gout. METHODS:We included all randomized controlled trials (RCTs) that compared ULTs with placebo or head to head. The primary efficacy endpoint was t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05272-4
更新日期:2021-02-01 00:00:00
abstract::The objectives of the study were to assess sleep disturbances in systemic lupus erythematosus (SLE) and to compare these with a working sample and a treatment-seeking sample reporting insomnia. The primary sample was 172 people with SLE. This sample represented 32% of all members of two lupus support association. Two ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0884-2
更新日期:2008-09-01 00:00:00
abstract::Acetabular protrusion (PA) as measured by a line crossing method was studied in 73 patients with juvenile rheumatoid arthritis (JRA) and its frequency found to be 12% (9/73), presenting bilaterally in 5 cases and unilaterally in 4. All patients had some other forms of radiological damage and the presence of PA was pre...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231556
更新日期:1993-03-01 00:00:00
abstract::Vitamin D is vital for musculoskeletal health and may be associated with subacute and chronic low back pain. The objective of this study was to estimate the prevalence of vitamin D deficiency among chronic low back pain (CLBP) and subacute low back pain (SLBP), and compare the same with healthy controls. This study wa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3798-z
更新日期:2018-05-01 00:00:00
abstract::Juvenile dermatomyositis (JDM) is a rare chronic inflammatory disease of unknown etiology and primarily involves muscle and skin. It is the most common idiopathic inflammatory myopathy of childhood. This study aimed to evaluate demographic and clinical features, laboratory data, treatment modalities, and outcome of pa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3530-4
更新日期:2017-02-01 00:00:00
abstract::We reported a case of dermatomyositis (DM) with liver disturbance in a 50-year-old Japanese female. She presented with fever, muscle weakness, and typical DM rashes. On clinical and serological examinations, the liver impairment was initially diagnosed as probable autoimmune hepatitis, which was denied by a histologic...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1397-3
更新日期:2010-08-01 00:00:00
abstract::Seventy-nine patients suffering from rheumatoid factor positive rheumatoid arthritis (RA) were included in this study. In each patient disease activity was assessed three times at two-week intervals during a four-week period. All factors that might possibly influence RA, except atmospheric conditions (AC) were held co...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206665
更新日期:1991-12-01 00:00:00
abstract::Either total hip arthroplasty (THA), total knee arthroplasty (TKA) or both were performed in 105 patients from 1981 to 1994. These patients were experiencing severe joint destruction in the lower extremities due to rheumatoid arthritis (RA). These patients were followed for more than 2 years after their last operation...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01452259
更新日期:1998-01-01 00:00:00
abstract::Hypercalcaemia is a common electrolyte abnormality. The vast majority of patients will be shown to have either hyperparathyroidism or malignancy. In less than 10% of patients other, less common causes of hypercalcaemia will be present. Systemic lupus erythematosus is a very rare cause of hypercalcaemia. It may be asso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170088
更新日期:2001-01-01 00:00:00
abstract::Children with juvenile idiopathic arthritis (JIA) may infrequently present with localized anterior knee pain or swelling, in addition to generalize knee pain induced by JIA. We report five cases of deep infrapatellar bursitis in children with JIA. The clinical features, radiological findings, management, and outcome o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1620-2
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:The association between hyperuricemia and insulin resistance (IR) has been demonstrated by many studies, but the traditional IR indexes are too impractical to be used in clinical practice for the recognition of the IR state in individuals with hyperuricemia. Therefore, we aimed to further investigate the asso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04671-6
更新日期:2019-11-01 00:00:00
abstract::The sternocostoclavicular (SCC) region is subject to the same diseases that occur in joints, with congenital and developmental anomalies, inflammatory and infectious diseases, soft tissue and bone tumors as well as the seronegative spondyloarthropathies, including ankylosing spondylitis, reactive arthritis, enteropath...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-0905-1
更新日期:2008-07-01 00:00:00
abstract::Information about the distribution of effusion within the arthritic knee joint should be considered in selecting an anatomical approach for arthrocentesis. We recorded ultrasound measurements of fluid distribution in the knees of patients attending our clinic for knee injections under ultrasound guidance. In a cross-s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-1987-3
更新日期:2012-08-01 00:00:00
abstract::The population of North Dakota is predominantly of Scandinavian (Norwegian) or German descent. We analyzed a cohort of all patients diagnosed with palindromic rheumatism (PR) and followed-up (by the investigator PK) at the St. Alexius Medical Center, Specialty Clinics, Bismarck, North Dakota, from August 16, 2006 to S...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-009-1280-2
更新日期:2010-01-01 00:00:00
abstract::Sarcoidosis is a multisystemic disease with cutaneous lesions present in about one fourth of patients. Cutaneous lesions may be specific or nonspecific based on the presence or the absence of sarcoidal granulomas. Subcutaneos sarcoidosis is the less frequent of the specific cutaneous lesions of sarcoidosis. We report ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-011-1731-4
更新日期:2011-08-01 00:00:00
abstract::Chorea is a rare complication of systemic lupus erythematosus (SLE) and is strongly related to the presence of antiphospholipid antibodies. Various infections may also be triggering factors in the development of choreiform movements. Additionally, Salmonella infection is the most common opportunistic bacterial infecti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0627-9
更新日期:2007-12-01 00:00:00
abstract::Chronic whiplash-associated disorders (WAD) remains a challenging condition for clinicians. There is substantial evidence for the presence of various cervical dysfunctions (e.g., increased cervical muscle tone and impaired cervical movement control), but their contribution to the complex clinical picture of subjects w...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-1083-x
更新日期:2009-03-01 00:00:00
abstract::Chronic pediatric musculoskeletal (MSK) conditions are a major cause of morbidity. The burden of pediatric rheumatic diseases in East Africa is largely unknown. The purposes of this study were to estimate frequencies and assess the spectrum of MSK-related diagnoses using ICD-10 diagnostic codes among outpatients at a ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4376-8
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to develop an understanding of treatment preferences in patients with inflammatory arthritis (IA) [rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)] focussing on treatment attributes that patients' value, their relative importan...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04843-4
更新日期:2020-04-01 00:00:00
abstract::To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patient...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208026
更新日期:1991-03-01 00:00:00
abstract::The presence of nail changes was investigated in 102 patients with nodal osteoarthritis of the hand. Nail lesions were seen in 14/102 patients (13.7%), a prevalence higher than that observed in 96 controls (4/96, 4.2%; chi square 4.37, p = 0.036). An increased risk of nail changes was associated with osteoarthritis of...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02249013
更新日期:1994-06-01 00:00:00
abstract::In the early stage of the COVID-19 pandemic, Belgian health authorities endorsed the interim guidelines for the treatment of COVID-19 pneumonia: hydroxychloroquine (HCQ) recommended for treatment of hospitalized patients with moderate to severe disease. As a growing number of patients were admitted, inevitably, our in...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05572-9
更新日期:2021-01-15 00:00:00
abstract::We describe a case of an 82-year-old woman with giant cell arteritis, who developed unilateral pitting oedema of the dorsum of the right hand, foot and distal part of the right forearm as well as tenosynovitis of the right wrist extensors, mild synovitis of the right wrist, metacarpophalangeal and metatarsophalangeal ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050061
更新日期:1999-01-01 00:00:00
abstract::The aim of the study was to describe the long-term toxicity of antirheumatic and anti-inflammatory drugs in a paediatric rheumatology clinic population. One hundred and seventeen children were studied on first admission to a paediatric rheumatology clinic and after a mean of 8.6 +/- 0.4 years of follow-up. Medical rec...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01451288
更新日期:1998-01-01 00:00:00
abstract::The objective of the study was to determine clinical factors associated with activity limitation and predictors of a change in activity limitation after 1 year in people with gout. Two hundred ninety-five participants with gout (disease duration < 10 years) attended a baseline assessment which included medical and dis...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4110-6
更新日期:2018-08-01 00:00:00
abstract::In the original version of this article the first name of the co-author was incorrectly spelled as "Khaled A. Alnaqbi". The correct spelling should have been "Khalid A. Alnaqbi". This is now presented correctly in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4282-0
更新日期:2018-11-01 00:00:00