Hypercalcaemia in systemic lupus erythematosus.

Abstract:

:Hypercalcaemia is a common electrolyte abnormality. The vast majority of patients will be shown to have either hyperparathyroidism or malignancy. In less than 10% of patients other, less common causes of hypercalcaemia will be present. Systemic lupus erythematosus is a very rare cause of hypercalcaemia. It may be associated with lymphadenopathy and pleuritis to constitute a distinct clinical entity described as 'hypercalcaemia-lymphoedema syndrome'. In these cases the pathophysiology of the hypercalcaemia is not completely understood. In some cases it is associated with elevated levels of parathyroid-related peptide (PTHrP). In others the level of PTHrP is normal, and it has been suggested that autoantibodies may cause hypercalcaemia by activating the PTH receptor. We describe a case of a woman who presented with severe hypercalcaemia, developed the hypercalcaemia-lymphodema syndrome and fulfilled the diagnostic criteria of systemic lupus erythematosus.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Berar-Yanay N,Weiner P,Magadle R

doi

10.1007/s100670170088

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

147-9

issue

2

eissn

0770-3198

issn

1434-9949

journal_volume

20

pub_type

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