Abstract:
BACKGROUND AND OBJECTIVES:The purpose of this study was to develop an understanding of treatment preferences in patients with inflammatory arthritis (IA) [rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)] focussing on treatment attributes that patients' value, their relative importance, and the risk-benefit trade-offs that characterise patients' choices around treatment. METHODS:A discrete choice experiment (DCE) approach was used. Attributes of interest were clinical efficacy; slowing of disease progression; risk of mild-moderate side effects; risk of severe side effects; frequency of administration; real-world product evidence; management of related conditions; and availability of a patient support programme. Using data from the DCE component, a restricted latent class model (LCM) was estimated to determine discrete 'classes' of treatment preferences. RESULTS:In this analysis, 206 participants were included (AS n = 59; PsA n = 62; RA n = 85). Two classes were identified. For 'class 1' (59.9%), the most important attributes (across all treatment modalities) were preventing disease progression, clinical efficacy and risk of mild-to-moderate side effects. For 'class 2' (40.1%), clinical and non-clinical attributes were important, and attribute importance depended on treatment modality. Patient demographic and treatment characteristics did not predict class membership. CONCLUSION:For most patients with IA, clinical efficacy, stopping disease progression and risks of mild-to-moderate side effects are important treatment attributes. Patients with prior biologic DMARD experience had greater preference for injection treatments. For a subset of patients, patient support programmes and the frequency of administration were important. Clinicians should be mindful of preferences when prescribing treatment to patients with IA.Key Points• Most patients consider clinical efficacy, stopping disease progression and the risk of mild-to-moderate side effects as important treatment attributes• Patients with prior biologic DMARD experience have greater preference for injection treatments.• For a subset of patients, patient support programmes, and the frequency of administration were important.• Clinicians should be mindful of preferences when prescribing treatment to patients with IA.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Ho KA,Acar M,Puig A,Hutas G,Fifer Sdoi
10.1007/s10067-019-04843-4subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1077-1089issue
4eissn
0770-3198issn
1434-9949pii
10.1007/s10067-019-04843-4journal_volume
39pub_type
杂志文章abstract::The vitamin D is involved in a wide variety of biological processes including bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation. Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR). A series of common single-nucleotide polymorphisms...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2639-6
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abstract:BACKGROUND:Visfatin is an adipokine and has a crucial role in pro-inflammatory response. The aim of this study was investigating the visfatin levels of gingival crevicular fluid (GCF) in patients with systemic lupus erythematosus (SLE) and chronic periodontitis and healthy subjects. MATERIALS AND METHODS:Sixty non-obe...
journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3887-z
更新日期:2018-03-01 00:00:00
abstract::The level of the N terminal fragment of procollagen III (P3NP) levels of 100 consecutive patients affected by rheumatoid arthritis (RA) were evaluated in comparison with disease activity markers (erythrocytes sedimentation rate, C reactive protein), immunological status (rheumatoid factors, immune complexes) and joint...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02283106
更新日期:1992-12-01 00:00:00
abstract::Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02114402
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pub_type: 杂志文章
doi:10.1007/s10067-020-05419-3
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0906-7
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abstract::Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system and that measures of hearing may be related to indices of RA disease activity. The aims of this study were to determine whether hearing loss in young subjects with rheumatoid ar...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0802-z
更新日期:2008-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0229-y
更新日期:2007-06-01 00:00:00
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doi:10.1007/s10067-009-1097-z
更新日期:2009-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208358
更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1007/s10067-015-3045-4
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pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-014-2642-y
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2020-11-14 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
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更新日期:2020-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
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更新日期:2019-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1898-8
更新日期:2012-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2641-z
更新日期:2014-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01451065
更新日期:1998-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1089-z
更新日期:2009-04-01 00:00:00