Antineutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus.

Abstract:

:We aimed to evaluate the presence of peripheral antineutrophil cytoplasmic antibodies (p-ANCA) and cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) in children with SLE and to correlate its association of laboratory findings. Twenty-one children with SLE were studied. Serum samples in patients were tested by indirect immunofluorescence (IIF) slide kit (INOVA) for c-ANCA and p-ANCA and by ELISA for myeloperoxidase (MPO-ANCA) and proteinase 3 (PR3-ANCA). All the patients but two were quiescent for lupus at the time of sampling. Sixteen of 21 patients showed positive IIF staining whereas only 5 had MPO-ANCA and 2 of nine PR3-ANCA. The data suggests that SLE may be associated p-ANCA directed against additional target antigens rather than MPO and may be implicated in the pathogenesis of SLE or may be only non-specific antibodies developed in lupus.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Bakkaloglu A,Topaloglu R,Saatçi U,Ozdemir S,Ozen S,Başsoy Y,Beşbaş N

doi

10.1007/BF01451065

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

265-7

issue

3

eissn

0770-3198

issn

1434-9949

journal_volume

17

pub_type

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