Abstract:
:We aimed to evaluate the presence of peripheral antineutrophil cytoplasmic antibodies (p-ANCA) and cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) in children with SLE and to correlate its association of laboratory findings. Twenty-one children with SLE were studied. Serum samples in patients were tested by indirect immunofluorescence (IIF) slide kit (INOVA) for c-ANCA and p-ANCA and by ELISA for myeloperoxidase (MPO-ANCA) and proteinase 3 (PR3-ANCA). All the patients but two were quiescent for lupus at the time of sampling. Sixteen of 21 patients showed positive IIF staining whereas only 5 had MPO-ANCA and 2 of nine PR3-ANCA. The data suggests that SLE may be associated p-ANCA directed against additional target antigens rather than MPO and may be implicated in the pathogenesis of SLE or may be only non-specific antibodies developed in lupus.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Bakkaloglu A,Topaloglu R,Saatçi U,Ozdemir S,Ozen S,Başsoy Y,Beşbaş Ndoi
10.1007/BF01451065subject
Has Abstractpub_date
1998-01-01 00:00:00pages
265-7issue
3eissn
0770-3198issn
1434-9949journal_volume
17pub_type
临床试验,杂志文章abstract::Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male:Female = 11.2:1), and in...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032322
更新日期:1985-03-01 00:00:00
abstract::In patients with fibromyalgia (FM) syndrome, stress and pain may chronically enhance sympathetic activity, altering cardiovascular response and inducing endothelial dysfunction. We investigated endothelial function in FM patients using echocardiography and analyzed whether endothelial function was affected by the clin...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1599-8
更新日期:2011-05-01 00:00:00
abstract::The effect of niflumic acid on hyaluronic acid and proteoglycan metabolism of human cartilage cells was investigated in vitro. Cartilage cells were obtained from five different donors. Niflumic acid levels used in the test systems ranged from 0 to 22 microgramsr/ml and were comparable to serum concentrations in humans...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030238
更新日期:1990-03-01 00:00:00
abstract::Efficacy of hip protector pads to prevent hip fracture is controversial. This study was done to evaluate two comparable groups for fracture risk. Two matched cohorts of long-term care residents in Canada, assessing the efficacy of hip protector pads. Evaluation included demographics, medications/diagnoses, cognition (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1115-1
更新日期:2009-06-01 00:00:00
abstract::In a Sidonian sarcophagus, from the Late Antique/early Christian period, skeletal remains of two persons were found. One of them, male, 30-50 years old, was found almost completely ankylosed, with highly osteoporotic bones and prominent erosion of joint surfaces. We diagnosed rheumatoid arthritis based on the eroded o...
journal_title:Clinical rheumatology
pub_type: 历史文章,杂志文章
doi:10.1007/s10067-016-3493-5
更新日期:2017-01-01 00:00:00
abstract::We describe two patients with pancreatitis. One patient had acute pancreatitis of biliary origin and presented with small joint polyarthritis and panniculitis lesions. The other patient was originally hospitalised for dyspnoea with bilateral pleural effusion, and subsequently developed migratory polyarthritis. During ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01451017
更新日期:1998-01-01 00:00:00
abstract::We investigated the occurrence of an active cytomegalovirus (CMV) infection in patients with polyarteritis nodosa (PAN). Eleven patients with PAN were screened for the presence of CMV-DNA in their blood using the polymerase chain reaction (PCR). Serum anti-CMV IgG and anti-CMV IgM antibodies were determined by enzyme-...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050148
更新日期:1999-01-01 00:00:00
abstract::Spontaneous fractures of the sternum are rare but worth knowing as they may simulate acute cardiac and pulmonary emergencies. A case of an insufficiency sternal fracture mimicking myocardial infarction and subsequent anginal pain is presented. The risk factors of this condition, its clinical features and the diagnosti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207687
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis. MATERIALS AND METHODS:We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10067-006-0227-0
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, m...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05573-8
更新日期:2021-01-02 00:00:00
abstract::The authors describe an atypical case of a patient having giant cell arteritis presenting only with fever, diagnosed by positron emission tomography and subsequently confirmed by temporal artery biopsy. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0831-7
更新日期:2008-06-01 00:00:00
abstract::Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02284051
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:This case-control study aimed to analyze the clinical features and determine the expression of type I interferon-induced genes in systemic lupus erythematosus (SLE) patients harboring the CD11b rs1143679 single-nucleotide polymorphism (SNP) and elucidate whether it is involved in the relapses of SLE. METHODS...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05330-x
更新日期:2020-08-12 00:00:00
abstract::Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diag...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-1074-y
更新日期:2009-04-01 00:00:00
abstract::The prognostic significance of class III major histocompatibility complex complement components, factor B (Bf), C4A and C4B, were studied in a 3-year prospective study of 73 patients with early RA. Patients with C4B null allele had higher disease activity with more radiological progression than patients with C4A null ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02238550
更新日期:1996-11-01 00:00:00
abstract::In the study of pathophysiological mechanisms in growth abnormalities of the juvenile knee in arthritis an animal model in dogs was developed. Arthritis was induced by intra-articular injections of Carrageenan. Prominent growth changes were enlargement of the distal femoral epiphysis, patellar squaring and decreased e...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030752
更新日期:1984-06-01 00:00:00
abstract::To clarify the roles of neutrophils in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitic neuropathy, we studied neutrophil extracellular traps (NETs) in peripheral nerve vasculitis. Stored nerve samples from 17 patients with microscopic polyangiitis (MPA) were immunohistochemically analyzed using a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3546-4
更新日期:2017-04-01 00:00:00
abstract::Pauci-immune necrotizing glomerulonephritis is a form of a rapidly progressive glomerulonephritis that is associated with the anti-neutrophil cytoplasmic antibodies (ANCA). ANCA-associated pauci-immune glomerulonephritis may be secondary to rheumatic diseases. We report on a patient with limited cutaneous systemic scl...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2010-8
更新日期:2012-08-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:This study examined whether phase angle (PhA) is associated with hip osteoarthritis (HOA) severity and quadriceps strength in patients with HOA. METHOD:A series of 549 patients with HOA, obtained from the Screening for People Suffering Sarcopenia in the Orthopedic cohort of Kobe study, were ana...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05419-3
更新日期:2020-09-29 00:00:00
abstract:OBJECTIVE:To identify factors associated with active tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). METHODS:We performed a retrospective case-control study in two tertiary care teaching hospitals in Medellín, Colombia. From January 2007 to December 2017, a total of 268 patients with SLE were in...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05225-x
更新日期:2021-01-01 00:00:00
abstract::The objective of the study was to determine clinical factors associated with activity limitation and predictors of a change in activity limitation after 1 year in people with gout. Two hundred ninety-five participants with gout (disease duration < 10 years) attended a baseline assessment which included medical and dis...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4110-6
更新日期:2018-08-01 00:00:00
abstract::The sternocostoclavicular (SCC) region is subject to the same diseases that occur in joints, with congenital and developmental anomalies, inflammatory and infectious diseases, soft tissue and bone tumors as well as the seronegative spondyloarthropathies, including ankylosing spondylitis, reactive arthritis, enteropath...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-0905-1
更新日期:2008-07-01 00:00:00
abstract::Although peripheral blood eosinophilia is observed in patients with active inflammatory rheumatoid arthritis (RA), RA is not a recognised cause of pulmonary eosinophilia. We describe a 55-year-old woman affected by chronic eosinophilic pneumonia (CEP) concomitantly with an initiation of RA. Both diseases responded rap...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0703-8
更新日期:2003-09-01 00:00:00
abstract::The aim of this study was to assess the role of oxidative stress in the pathogenesis of Henoch-Schönlein purpura (HSP) vasculitis. The activities of catalase (CAT), arylesterase (ARYL), and paraoxonase (PON) as antioxidant enzymes and serum malondialdehyde (MDA) level as an indicator of lipid peroxidation, together wi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0671-5
更新日期:2008-02-01 00:00:00
abstract::Atherosclerosis has been shown to be increased in chronic inflammatory diseases including ankylosing spondylitis (AS). Impaired endothelial function, the first step in atherosclerosis, may be reflected by changes in various endothelial biomarkers of hemostasis and the release of several cellular adhesion molecules or ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1760-z
更新日期:2012-01-01 00:00:00
abstract::The investigation concerned changes in vitamin A derivatives (retinol and retinyl) content in serum of patients suffering from two types of rheumatic diseases--rheumatoid arthritis (RA) and osteoarthrosis. Healthy women of similar age served as control. It was found that the retinol content of the serum in the group s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02042773
更新日期:1982-09-01 00:00:00
abstract::Anaerobic bacteria are uncommon pathogens in septic arthritis. We report a case of pyarthrosis of the right hip caused by Fusobacterium nucleatum, following a transient synovitis in an otherwise healthy boy. There are only a few cases involving this species described in the literature. This report illustrates the diff...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170072
更新日期:2001-01-01 00:00:00
abstract::Vitamin D is vital for musculoskeletal health and may be associated with subacute and chronic low back pain. The objective of this study was to estimate the prevalence of vitamin D deficiency among chronic low back pain (CLBP) and subacute low back pain (SLBP), and compare the same with healthy controls. This study wa...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3798-z
更新日期:2018-05-01 00:00:00
abstract::We and others have previously shown that IL-17 is elevated in the synovial fluid of patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA) having acute synovitis. Major source for IL-17 is Th17 cells, which differentiate from Th0 cells under the influence of TGF-β and IL-6, IL1-β and are ma...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1646-5
更新日期:2011-06-01 00:00:00
abstract::Chronic hepatitis C virus (HCV) viremia has been known to provoke a plethora of autoimmune syndromes referred to as extrahepatic manifestations of chronic HCV infection. Aim of the current study was to assess the prevalence of rheumatologic manifestations among Egyptians with hepatitis C infection and its' association...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1463-x
更新日期:2010-12-01 00:00:00