The investigation of killer cell immunoglobulin-like receptor genotyping in patients with systemic lupus erytematosus and systemic sclerosis.

Abstract:

:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the production of autoantibodies and the involvement of multiple organ systems. Systemic sclerosis (SSc) is another autoimmune disease that causes fibrosis. We will aim to analyse the role of killer cell immunoglobulin-like receptor (KIR) genotypes and their existence with the respective HLA ligands in patients with SLE and SSc. Forty-five SLE, 25 SSc and 40 healthy controls were included. We examined the presence/absence of KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5A, 2DL5B, 2DS1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1, 2DP1, 3DP1 and their known HLA ligands. In the SLE group, the KIR2DL5, KIR2DL5B and KIR2DS3 genes were significantly more frequent, and KIR2DL3 gene was significantly less than in controls (p values <0.05). In SSc patients, the KIR2DS3 gene was more frequent than in controls (p = 0.032). The KIR2DL3 gene was detected more frequently in controls while KIR2DS3 gene was more frequent in the patient group when SLE and SSc patients were combined (p values < 0.05). The KIR2DS2/HLA-C and KIR2DS2/HLA-C combinations were significantly more in both SLE and SSc groups than in controls. The KIR2DL2 and KIR2DL5B genes were protective from neurologic involvement in SLE patients (p values <0.05). The variations of some KIR genes such as KIR2DL5, KIR2DL5B, KIR2DS3 and KIR2DL3 may have a role in the pathogenesis of SLE and SSc. Also, the presence of KIR2DL2 and KIR2DL5B may cause major organ involvement, like neurologic involvement, in SLE.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Tozkır JD,Tozkır H,Gürkan H,Dönmez S,Eker D,Pamuk GE,Pamuk ÖN

doi

10.1007/s10067-016-3222-0

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

919-25

issue

4

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-016-3222-0

journal_volume

35

pub_type

杂志文章
  • Charcot joint in idiopathic sensorimotor neuropathy.

    abstract::Charcot joint or neuropathic arthropathy is described in certain neurological conditions. We report the case of a man who presented with a swollen ankle 10 days after a long walk, which rapidly progressed to a Charcot joint. A neurological examination revealed areflexia and insensitivity to temperature and pain. Elect...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670050036

    authors: Chappel R,Willems J,Martin JJ

    更新日期:2000-01-01 00:00:00

  • Response to traditional disease-modifying anti-rheumatic drugs in indigent South Africans with early rheumatoid arthritis.

    abstract::The clinical response to traditional disease-modifying anti-rheumatic drugs (DMARDs) in indigent South Africans with early rheumatoid arthritis was investigated. A cohort of patients with early (≤2 years) RA who were DMARD-naïve at inception were prospectively assessed for response to DMARDs using the Simplified Disea...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1900-5

    authors: Hodkinson B,Musenge E,Ally M,Meyer PW,Anderson R,Tikly M

    更新日期:2012-04-01 00:00:00

  • An adolescent girl with Meyer-Betz syndrome.

    abstract::Idiopathic paroxysmal rhabdomyolysis indicating a classical triad of symptoms consisting of muscle pain, weakness, and discolored urine is known as "Meyer-Betz syndrome". It may result in acute renal failure due to precipitation of the myoglobin casts in the tubuli or to the direct toxic effects of myoglobin to the tu...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0091-3

    authors: Kasap B,Soylu A,Türkmen M,Kavukcu S

    更新日期:2006-11-01 00:00:00

  • Synovial cyst in juvenile idiopathic arthritis.

    abstract::Small synovial cysts are a common manifestation of juvenile idiopathic arthritis; large brachial cysts, however, are a rare sign of the disease and they must be differentiated from other soft tissue swelling which are not related to articular involvement. We describe the case of three children with juvenile idiopathic...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-0860-x

    authors: Dell'Era L,Vercellesi P,Forzenigo LV,Carnelli V,Corona F

    更新日期:2008-12-01 00:00:00

  • Systemic lupus erythematosus presenting as catatonic schizophrenia.

    abstract::A patient fulfilling the diagnostic criteria for systemic lupus erythematosus and presenting with catatonic schizophrenia is described. Psychiatric features of the disease and their management are discussed. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031619

    authors: Tishler M,Abramov AL

    更新日期:1985-09-01 00:00:00

  • Osteoporosis in rheumatoid arthritis: effect of disease activity.

    abstract::In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis (RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus controls and evalu...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02207677

    authors: Celiker R,Gökçe-Kutsal Y,Cindas A,Ariyürek M,Renda N,Koray Z,Basgöze O

    更新日期:1995-07-01 00:00:00

  • In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up.

    abstract::This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n=90) were included prospectively and followed up ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2569-3

    authors: Emad Y,Anbar A,Abo-Elyoun I,El-Shaarawy N,Al-Hanafi H,Darwish H,Gamil M,Rasker JJ

    更新日期:2014-06-01 00:00:00

  • Multifocal avascular necrosis revealing antiphospholipid syndrome.

    abstract::Osteonecrosis (ON) is a clinical entity characterized by death of bone marrow and trabecular bone as a result of disruption of blood supply to the bone. The antiphospholipid (APL) syndrome is characterized by arterial and/or venous thrombosis and pregnancy morbidity in association with APL antibodies. The involvement ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0716-9

    authors: Rostom S,Bahiri R,Hajjaj-Hassouni N

    更新日期:2008-02-01 00:00:00

  • Prolactinoma and systemic lupus erythematosus: do serum prolactin levels matter?

    abstract::The lactogenic hormone prolactin is produced in part by cells of the immune system and serves as an upregulator of immune function. Hyperprolactinemia is common in patients with systemic lupus erythematosus (SLE), raising the possibility that the hormone contributes to the excessive immune response in the disease. The...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0117-x

    authors: Li M,Keiser HD,Peeva E

    更新日期:2006-07-01 00:00:00

  • Predictive factors of rapidly progressive-interstitial lung disease in patients with clinically amyopathic dermatomyositis.

    abstract::Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, showing a high incidence of lung involvements. The aim of this study is to identify risk factors, other than melanoma differentiation-associated protein (MDA)-5, for developing rapidly progressive-interstitial lung disease (RP-ILD) in ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-3139-z

    authors: Xu Y,Yang CS,Li YJ,Liu XD,Wang JN,Zhao Q,Xiao WG,Yang PT

    更新日期:2016-01-01 00:00:00

  • Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction.

    abstract::Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diag...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-1074-y

    authors: Ebina K,Fukuhara A,Ando W,Hirao M,Koga T,Oshima K,Matsuda M,Maeda K,Nakamura T,Ochi T,Shimomura I,Yoshikawa H,Hashimoto J

    更新日期:2009-04-01 00:00:00

  • Insulin and new bone formation in diffuse idiopathic skeletal hyperostosis.

    abstract::The tendency of patients with DISH towards obesity or an adult onset of diabetes has been reflected in marked hyperinsulinaemia following glucose challenge. It is hypothesized that insulin at prolonged and high physiologic levels promotes new bone growth, particularly in the entheseal regions. These areas are also sub...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031611

    authors: Littlejohn GO

    更新日期:1985-09-01 00:00:00

  • A case of myeloperoxidase-antineutrophil cytoplasmic antibody positive-polyarteritis nodosa complicated by interstitial pneumonia and rapidly progressive renal failure.

    abstract::A 73-year-old woman was admitted to our hospital because of persistent high fever and cough, generalized myalgia, and renal dysfunction. Laboratory examination revealed severe inflammatory signs, pulmonary fibrosis, progression of renal impairment with active nephritic urinary sediments, and a high titer of myeloperox...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0142-9

    authors: Sugimoto T,Kanasaki K,Koyama T,Yokomaku Y,Yasuda H,Kashiwagi A,Koya D

    更新日期:2007-03-01 00:00:00

  • Myelodysplastic and myeloproliferative syndromes associated with giant cell arteritis and polymyalgia rheumatica: a coincidental coexistence or a causal relationship?

    abstract::A variety of systemic autoimmune disorders have been reported in patients with myelodysplastic and myeloproliferative syndromes. A possible association with polymyalgia rheumatica and giant cell arteritis has also been recognised. We report another case of polymyalgia rheumatica and one of giant cell arteritis associa...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670200081

    authors: Espinosa G,Font J,Muñoz-Rodríguez FJ,Cervera R,Ingelmo M

    更新日期:2002-08-01 00:00:00

  • Correction to: Musculoskeletal infections caused by Aerococcus urinae: a case-based review.

    abstract::The presentation of the Table 1 of the original version of this article was incorrectly published. The Table is now presented correctly in this article. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10067-018-4098-y

    authors: Greco M,Rúa-Figueroa Í,Ghiglione S,Santana Medina E,Quevedo Abeledo JC,Rodríguez-Lozano C

    更新日期:2018-09-01 00:00:00

  • Severity of symptoms persists for decades in fibromyalgia-a 26-year follow-up study.

    abstract::The aim of this study is to find out the outcome of 28 patients who got the diagnosis of primary fibromyalgia (pFM) 26 years ago. In 1986, 56 patients with widespread pain were examined and filled in a base questionnaire (BQ). Of them, 42 fulfilled the Yunus criteria for pFM. Twenty-six years later, addresses of 38 pa...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3967-0

    authors: Isomeri R,Mikkelsson M,Partinen M,Kauppi MJ

    更新日期:2018-05-01 00:00:00

  • Acute and long-term effect of infliximab on humoral and echocardiographic parameters in patients with chronic inflammatory diseases.

    abstract::Tumor necrosis factor alpha (TNF-alpha) plays an important role in the pathogenesis of chronic inflammatory diseases, i.e., rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD), and ulcerative colitis (UC). Anti-TNF-alpha strategies are successfully used in their treatment. However, their effec...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2091-4

    authors: Tomáš L,Lazúrová I,Pundová L,Oetterová M,Zakuciová M,Petrášová D,Studenčan M

    更新日期:2013-01-01 00:00:00

  • 'Isn't it ironic?' Beliefs about the unacceptability of emotions and emotional suppression relate to worse outcomes in fibromyalgia.

    abstract::Beliefs about the unacceptability of experiencing and expressing emotions have been found to be related to worse outcomes in people with persistent physical symptoms. The current study tested mediation models regarding emotional suppression, beliefs about emotions, support-seeking and global impact in fibromyalgia. On...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3590-0

    authors: Bowers H,Wroe AL,Pincus T

    更新日期:2017-05-01 00:00:00

  • Non-canonical manifestations of familial Mediterranean fever: a changing paradigm.

    abstract::Paroxysmal crises of fever and systemic inflammation herald familial Mediterranean fever (FMF), considered as the archetype of all inherited systemic autoinflammatory diseases. Inflammatory bouts are characterized by short-term and self-limited abdominal, thoracic, and/or articular symptoms which subside spontaneously...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-015-2916-z

    authors: Rigante D,Lopalco G,Tarantino G,Compagnone A,Fastiggi M,Cantarini L

    更新日期:2015-09-01 00:00:00

  • A cross-sectional study of autoantibody profiles in the Waikato systemic sclerosis cohort, New Zealand.

    abstract::The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CEN...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-2981-3

    authors: Chang WS,Schollum J,White DH,Solanki KK

    更新日期:2015-11-01 00:00:00

  • Gout: a disease involved with complicated immunoinflammatory responses: a narrative review.

    abstract::Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and subcutaneous sites. In recent years, with the continuous research on gout animal models and patient clinical investigations, the mechanism of i...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-020-05090-8

    authors: Wu M,Tian Y,Wang Q,Guo C

    更新日期:2020-10-01 00:00:00

  • Correction to: Microstructure of osteophytes in medial knee osteoarthritis.

    abstract::The above article originally published with an error present in Table 2 and is now presented correctly in this article. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10067-018-4280-2

    authors: Kizaki K,Uchida S,Yamashita F,Tsukamoto M,Azuma K

    更新日期:2018-10-01 00:00:00

  • Venous vessel wall thickness in lower extremity is increased in male patients with Behcet's disease.

    abstract::Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-on...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04470-z

    authors: Alibaz-Oner F,Ergelen R,Mutis A,Erturk Z,Asadov R,Mumcu G,Ergun T,Direskeneli H

    更新日期:2019-05-01 00:00:00

  • Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample.

    abstract::Hyperuricemia is not only a risk factor for gout but also an independent determinant of hypertension, diabetes, and chronic kidney diseases. Although the incidence of gout in Korean adults is increasing, epidemiologic studies on hyperuricemia in the general Korean population are limited. Thus, this study aimed at eval...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4130-2

    authors: Kim Y,Kang J,Kim GT

    更新日期:2018-09-01 00:00:00

  • High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus.

    abstract::Paediatric systemic lupus erythematosus (pSLE) refers to childhood-onset systemic lupus erythematosus. pSLE has its own unique characteristics, and its pathogenesis is unclear. To study the relationship between microRNAs (miRNAs) and pSLE, we selected three pSLE patients who were newly diagnosed and had not yet been t...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2583-5

    authors: Zhu J,Huang X,Su G,Wang L,Wu F,Zhang T,Song G

    更新日期:2014-06-01 00:00:00

  • Hypertrophic pachymeningitis and undifferentiated connective tissue disease: a case report and review of the literature.

    abstract::A 63-year-old man with hypertrophic pachymeningitis (HP) and an undifferentiated connective tissue disease is described. Combined therapy with prednisolone and azathioprine improved his symptoms. The association between an undifferentiated connective tissue disease and HP is discussed. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0018-z

    authors: Lampropoulos CE,Zain M,Jan W,Nader-Sepahi A,Sabin IH,D' Cruz DP

    更新日期:2006-05-01 00:00:00

  • Bone metabolism in patients with rheumatoid arthritis.

    abstract::Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02284051

    authors: Bijlsma JW

    更新日期:1988-03-01 00:00:00

  • Safety profile of the interleukin-1 inhibitors anakinra and canakinumab in real-life clinical practice: a nationwide multicenter retrospective observational study.

    abstract::A few studies have reported the safety profile of interleukin (IL)-1 blockers from real life. The aim of this study is to describe anakinra (ANA) and canakinumab (CAN) safety profile in children and adults, based on data from a real-life setting. Demographic, clinical, and therapeutic data from patients treated with A...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10067-018-4119-x

    authors: Sota J,Vitale A,Insalaco A,Sfriso P,Lopalco G,Emmi G,Cattalini M,Manna R,Cimaz R,Priori R,Talarico R,de Marchi G,Frassi M,Gallizzi R,Soriano A,Alessio M,Cammelli D,Maggio MC,Gentileschi S,Marcolongo R,La Torre F,

    更新日期:2018-08-01 00:00:00

  • Determinants of serum uric acid levels in an adult general population: results from the Moli-sani Study.

    abstract:OBJECTIVES:High levels of serum uric acid (UA) are associated with cerebro-cardiovascular disease risk factors. This study aimed at evaluating the main determinants of serum UA levels in relation to biochemical, lifestyle, and clinical variables. METHODS:The study population included 15,594 participants (48% men, age ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05288-w

    authors: Magnacca S,Costanzo S,De Curtis A,Di Castelnuovo A,Olivieri M,Cerletti C,de Gaetano G,Donati MB,Iacoviello L,Moli-sani Study Investigators.

    更新日期:2020-07-16 00:00:00

  • Causes of death in hospitalized patients with systemic lupus erythematosus: a 10-year multicenter nationwide Chinese cohort.

    abstract::To estimate the mortality and describe the causes of death in a large multicenter cohort of hospitalized patients with SLE in China. This was a retrospective study of a nationwide SLE cohort (10 centers, 29,510 hospitalized patients) from 2005 to 2014 in China. Standardized mortality ratios (SMRs) were calculated for ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10067-018-4259-z

    authors: Wu XY,Yang M,Xie YS,Xiao WG,Lin J,Zhou B,Guan X,Luo CN,Che N,Liu XZ,Wang C,Teng JL,Cheng XB,Ye JN,Su YT,Shi H,Yin YF,Liu MR,Sun Y,Hu QY,Zhou ZC,Chi HH,Liu Y,Zhang X,Chen JW,Zhang MJ,Zhao DB,Yang CD,

    更新日期:2019-01-01 00:00:00