Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample.

Abstract:

:Hyperuricemia is not only a risk factor for gout but also an independent determinant of hypertension, diabetes, and chronic kidney diseases. Although the incidence of gout in Korean adults is increasing, epidemiologic studies on hyperuricemia in the general Korean population are limited. Thus, this study aimed at evaluating the prevalence of hyperuricemia and its associated factors among non-institutionalized Korean adults. The present study included 5548 participants (2403 men and 3145 women) aged ≥ 19 years from The Korea National Health and Nutrition Examination Survey. Based on the new 2016 census data, the age-standardized prevalence and mean uric acid level were calculated using the chi-square test and t test, respectively. A multivariate logistic regression analysis was performed to evaluate the risk factors associated with hyperuricemia. The age-standardized prevalence of hyperuricemia and mean uric acid level in the general Korean population was 11.4% (17.0% in men and 5.9% in women) and 5.1 mg/dL (5.83 mg/dL in men and 4.36 mg/dL in women), respectively. The prevalence of hyperuricemia was high in young Korean adults, and a U-shaped association was observed between hyperuricemia and age. While obesity, metabolic syndrome, renal impairment, and low-grade inflammation were positively associated with hyperuricemia in both sexes, alcohol consumption, education, and current smoking status had a positive association with hyperuricemia only in women. Hyperuricemia is prevalent in the young population in Korea, and special efforts are necessary to reduce the potential harmful effects of hyperuricemia on the health of adults, particularly the younger-generation adults, in Korea.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Kim Y,Kang J,Kim GT

doi

10.1007/s10067-018-4130-2

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

2529-2538

issue

9

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-018-4130-2

journal_volume

37

pub_type

杂志文章
  • Ultrasonography of occipital arteries to diagnose giant cell arteritis: a case series and literature review.

    abstract::We describe four cases of giant cell arteritis (GCA) that presented with occipital headache in the last 6 months. Typical ultrasound features of GCA were found in the occipital arteries which helped to confirm the diagnosis. One patient had already suffered significant visual loss by the time the diagnosis was made, r...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-017-3946-5

    authors: Pinnell J,Tiivas C,Perkins P,Blake T,Saravana S,Dubey S

    更新日期:2018-02-01 00:00:00

  • Pulmonary haemorrhage and focal necrotizing glomerulonephritis in a case of systemic sclerosis.

    abstract::We report a case of a 53-year-old woman diagnosed of systemic sclerosis. She underwent an episode of pulmonary haemorrhage, characterized by haemoptysis, sudden anaemization, and bilateral alveolar infiltration during her hospitalization, which was resolved with steroid treatment. Subsequently, she developed a focal n...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02207098

    authors: Alvarez Vega JL,Salazar Vallinas JM,Ortega Alberdi R,Muñoz Sanz A,Turegano JM,Fernandez Alonso J

    更新日期:1992-03-01 00:00:00

  • Ultrasound elastography-based assessment of the elasticity of the supraspinatus muscle in impingement syndrome: does elastography has any diagnostic value?

    abstract::Ultrasound elastography (UE) is a new ultrasound-based imaging technique that provides information about elasticity and stiffness of tissues. This cross-sectional study aimed to identify the diagnostic importance of UE in supraspinatus impingement syndrome. Forty-one subjects, aged 38-70 years, were included in the st...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3928-7

    authors: Demirel A,Baykara M,Koca TT,Berk E

    更新日期:2018-06-01 00:00:00

  • Pain mediates the association between physical activity and the impact of fibromyalgia on daily function.

    abstract::This study quantified the association between recreational physical activity and daily function in women with fibromyalgia, and determined if this association is mediated by symptoms of pain, depression, or body mass. Twenty-three women diagnosed with fibromyalgia participated in an observational survey study. Recreat...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2386-0

    authors: Umeda M,Corbin LW,Maluf KS

    更新日期:2015-01-01 00:00:00

  • Visceral leishmaniasis infection in a patient with rheumatoid arthritis treated with etanercept.

    abstract::Visceral leishmaniasis (VL) is a severe disease that can develop in immunocompromised patients. Antitumor necrosis factor-alpha (TNF-alpha) treatment of rheumatoid arthritis can result in clinical benefits, but with an increased risk of opportunistic infections. Leishmania infection in patients treated with TNF-alpha ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0356-5

    authors: Bagalas V,Kioumis I,Argyropoulou P,Patakas D

    更新日期:2007-08-01 00:00:00

  • Association of juvenile idiopathic arthritis and morphea: a case series.

    abstract::The association of different autoimmune diseases in the same subject is not uncommon, also in the pediatric age. The coexistence of morphea and juvenile idiopathic arthritis (JIA) is however exceptional. We report four such cases. Unlike the few other reported cases, in 3/4 of our patients, morphea appeared well after...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-019-04850-5

    authors: Giani T,Madera A,Cimaz R

    更新日期:2020-04-01 00:00:00

  • Clinical spectrums and outcomes of necrotizing autoimmune myopathy versus other idiopathic inflammatory myopathies: a multicenter case-control study.

    abstract:OBJECTIVE:To investigate the clinical characteristics, laboratory features, and treatment outcomes of Thai patients compared between those with necrotizing autoimmune myopathy (NAM) and those with other idiopathic inflammatory myopathies (IIMs) or non-NAM. METHODS:This multicenter case-control study included patients ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10067-019-04756-2

    authors: Yongchairat K,Tanboon J,Waisayarat J,Narongroeknawin P,Chevaisrakul P,Dejthevaporn C,Katchamart W

    更新日期:2019-12-01 00:00:00

  • Modifiable cardiovascular risk factors in patients with ankylosing spondylitis.

    abstract::The aim of this study was to evaluate whether modifiable cardiovascular disease (CVD) risk factors, e.g. atherogenic blood lipids, hypertension and lifestyle-related factors such as smoking, diet and physical inactivity, differ among patients with ankylosing spondylitis (AS) in comparison to the general population. Ei...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2410-4

    authors: Sundström B,Johansson G,Johansson I,Wållberg-Jonsson S

    更新日期:2014-01-01 00:00:00

  • Risk of non-melanoma skin cancer for rheumatoid arthritis patients receiving TNF antagonist: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Tumor necrosis factor inhibitors (anti-TNF) have become the standard treatment for rheumatoid arthritis (RA). However, evidence is inconsistent as to whether RA patients with anti-TNF are associated with an increased risk of non-melanoma skin cancer (NMSC) compared with those without anti-TNF. We performed a ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10067-019-04865-y

    authors: Wang JL,Yin WJ,Zhou LY,Zhou G,Liu K,Hu C,Zuo XC,Wang YF

    更新日期:2020-03-01 00:00:00

  • Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells.

    abstract::B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of pat...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0665-3

    authors: Nakiri Y,Minowa K,Suzuki J,Mitsuo A,Amano H,Morimoto S,Tokano Y,Takasaki Y

    更新日期:2007-10-01 00:00:00

  • Effect of delayed diagnosis on disease course and management of Churg-Strauss syndrome: a retrospective study.

    abstract::Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2127-9

    authors: Sokołowska B,Szczeklik W,Mastalerz L,Kuczia P,Wodkowski M,Stodółkiewicz E,Macioł K,Musiał J

    更新日期:2013-03-01 00:00:00

  • Comparison of signal detection of tumour necrosis factor-α inhibitors using the Korea Adverse Events Reporting System Database, 2005-2016.

    abstract:OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04802-z

    authors: Ha D,Lee SE,Song I,Lim SJ,Shin JY

    更新日期:2020-02-01 00:00:00

  • Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients.

    abstract::Over a period of 10 years 34 patients were diagnosed as suffering from palindromic rheumatism. Eighty-one percent of the patients were of North African origin. This is significantly higher (p = 0.01) than the age-adjusted origin of the general population in the region. Attacks were usually monoarthritic or oligoarthri...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02032105

    authors: Eliakim A,Neumann L,Horowitz J,Buskila D,Kleiner-Baumgarten A,Sukenik S

    更新日期:1989-12-01 00:00:00

  • Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency.

    abstract::Calciphylaxis is a rare and life-threatening condition of progressive cutaneous necrosis secondary to small and medium-sized vessel calcification that is seen almost exclusively in patients with end-stage renal disease and hyperparathyroidism. We report a case of calciphylaxis that may very well be due to a long-term ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670200016

    authors: Korkmaz C,Dündar E,Zubaroğlu I

    更新日期:2002-02-01 00:00:00

  • Non-canonical manifestations of familial Mediterranean fever: a changing paradigm.

    abstract::Paroxysmal crises of fever and systemic inflammation herald familial Mediterranean fever (FMF), considered as the archetype of all inherited systemic autoinflammatory diseases. Inflammatory bouts are characterized by short-term and self-limited abdominal, thoracic, and/or articular symptoms which subside spontaneously...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-015-2916-z

    authors: Rigante D,Lopalco G,Tarantino G,Compagnone A,Fastiggi M,Cantarini L

    更新日期:2015-09-01 00:00:00

  • Tender points, depressive and functional symptoms: comparison between fibromyalgia and major depression.

    abstract::The degree of symptomatic overlap between fibromyalgia and major depression should be estimated by assessing the amount of local tenderness and the frequency and severity of depressive and functional symptoms. Tender points were assessed by palpation and symptoms by psychometric scales in 30 patients with fibromyalgia...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02238767

    authors: Fassbender K,Samborsky W,Kellner M,Müller W,Lautenbacher S

    更新日期:1997-01-01 00:00:00

  • Cardiovascular risk stratification and appropriate use of statins in patients with systemic lupus erythematosus according to different strategies.

    abstract:INTRODUCTION/OBJECTIVES:Cardiovascular risk management of patients with systemic lupus erythematosus (SLE) is medically relevant. The objectives were to estimate the cardiovascular risk by different strategies in patients with SLE, analyzing which proportion of patients would be candidates to receive statin therapy, an...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04856-z

    authors: Masson W,Rossi E,Mora-Crespo LM,Cornejo-Peña G,Pessio C,Gago M,Alvarado RN,Scolnik M

    更新日期:2020-02-01 00:00:00

  • Smoking and Behçet's disease.

    abstract::It has recently been claimed that some of the symptoms in patients with Behçet's disease (BD) can be activated after the patient has stopped smoking. In this study we investigated the effect of smoking on the symptoms of Behçet's disease. Fifty asymptomatic current smokers (CS) who promised to stop smoking (group 1) a...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670070020

    authors: Soy M,Erken E,Konca K,Ozbek S

    更新日期:2000-01-01 00:00:00

  • Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.

    abstract::We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine sampl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0632-z

    authors: Otukesh H,Chalian M,Hoseini R,Chalian H,Hooman N,Bedayat A,Yazdi RS,Sabaghi S,Mahdavi S

    更新日期:2007-12-01 00:00:00

  • Behçet's disease in Lebanon: clinical profile, severity and two-decade comparison.

    abstract::The aim of this study is to describe the clinical features of Lebanese patients with Behçet's disease (BD) followed up at a tertiary care center in Lebanon. A retrospective review of medical records of 90 patients who fulfilled the International Study Group (ISG) criteria for diagnosis was performed. The clinical char...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0058-4

    authors: Hamdan A,Mansour W,Uthman I,Masri AF,Nasr F,Arayssi T

    更新日期:2006-05-01 00:00:00

  • From scleredema to AL amyloidosis: disease progression or coincidence? Review of the literature.

    abstract::Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloido...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-004-1076-3

    authors: Dziadzio M,Anastassiades CP,Hawkins PN,Potter M,Gabrielli A,Brough GM,Black CM,Denton CP

    更新日期:2006-02-01 00:00:00

  • Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.

    abstract::We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoprol...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02231567

    authors: Taillan B,Garnier G,Castanet J,Ferrari E,Pesce A,Dujardin P

    更新日期:1993-03-01 00:00:00

  • Hypofixation on bone scintigraphy in reflex sympathetic dystrophy syndrome.

    abstract::We report an adult case of reflex sympathetic dystrophy. In contrast to the usual findings in adults, three phase bone scintigraphy showed decreased bloodflow and bloodpool with hypofixation on delayed steady state bone scan of the affected lower limb. In spite of various therapeutic attempts severe dystrophy develope...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02208035

    authors: Williame LM,Sand A

    更新日期:1991-03-01 00:00:00

  • Tuberculosis infection in patients with systemic lupus erythematosus: pulmonary and extra-pulmonary infection compared.

    abstract::Systemic lupus erythematosus (SLE) patients had an increased susceptibility to tuberculosis (TB). The aim of this study was to investigate the prevalence and clinical characteristics of TB in SLE patients, with focus on the differences between pulmonary and extra-pulmonary TB. This is a retrospective study that review...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0741-8

    authors: Hou CL,Tsai YC,Chen LC,Huang JL

    更新日期:2008-05-01 00:00:00

  • Tailored approach to early psoriatic arthritis patients: clinical and ultrasonographic predictors for structural joint damage.

    abstract::This study aims to identify the clinical predictors of arthritis in patients with psoriasis and to evaluate the use of musculoskeletal ultrasonography (US) as a predictor for inflammatory structural progression in psoriatic patients. Measures of association (odds ratio (OR)) were tested, in a prospective, cohort 1-yea...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2630-2

    authors: El Miedany Y,El Gaafary M,Youssef S,Ahmed I,Nasr A

    更新日期:2015-02-01 00:00:00

  • Vascular complications in systemic sclerosis: a prospective cohort study.

    abstract::Two major complications in scleroderma patients that cause substantial morbidity and mortality are ischemic digital lesions (DL) and pulmonary hypertension (PH). The clinician's ability to predict which patients will develop these complications is imperfect. We conducted a prospective observational cohort study of 300...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4148-5

    authors: Mecoli CA,Shah AA,Boin F,Wigley FM,Hummers LK

    更新日期:2018-09-01 00:00:00

  • Implication of invalidation concept in fibromyalgia diagnosis.

    abstract:OBJECTIVES:The invalidation or social pain is an important but neglected issue in polysymptomatology of fibromyalgia (FM). This study sought whether tracing-perceived invalidation could be effective to discriminate between the presence and absence of FM in chronic pain patients with respect to five different sources, i...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05515-4

    authors: Ghavidel-Parsa B,Bidari A,Tohidi S,Shenavar I,Kazemnezhad Leyli E,Hosseini K,Khosousi MJ

    更新日期:2021-01-07 00:00:00

  • Serum substance P: an indicator of disease activity and subclinical inflammation in rheumatoid arthritis.

    abstract::The aim of the is study is to examine the role of serum substance P (SP) levels as a simple biomarker for rheumatoid arthritis (RA) disease activity, its correlation with other markers of disease activity, and with selected clinical parameters. The study comprised 90 RA patients and 24 healthy controls. RA activity wa...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3929-6

    authors: Barbosa-Cobos RE,Lugo-Zamudio G,Flores-Estrada J,Becerril-Mendoza LT,Rodríguez-Henríquez P,Torres-González R,Moreno-Eutimio MA,Ramirez-Bello J,Moreno J

    更新日期:2018-04-01 00:00:00

  • Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity.

    abstract::Increased IFN-γ levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-γ, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-tim...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4138-7

    authors: Liu M,Liu J,Hao S,Wu P,Zhang X,Xiao Y,Jiang G,Huang X

    更新日期:2018-10-01 00:00:00

  • Ultrasound-guided insulin injection for carpal tunnel syndrome in type 2 diabetes mellitus patients.

    abstract:OBJECTIVE:To compare effectiveness of ultrasound-guided local insulin injection, local steroid injection, and local steroid followed by insulin injections in treating mild to moderate carpal tunnel syndrome (CTS) in type 2 diabetes mellitus (DM). METHOD:Study included 60 patients with electrophysiologic evidence of mi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10067-019-04638-7

    authors: Kamel SR,Sadek HA,Hamed A,Sayed OA,Mahmud MH,Mohamed FA,El Sagher GM,Aly LH

    更新日期:2019-10-01 00:00:00