Abstract:
:Biologic therapies have brought improved efficacy in the field of rheumatoid arthritis (RA), but their use in clinical practice may be limited by concerns over cost. Predictive models are, therefore, needed to identify those people with RA with the worst potential outcomes, who will benefit most from the use of these drugs. A variety of studies have investigated factors that will predict the onset of RA to allow preventative intervention and the identification of prognostic factors to guide the need for aggressive treatment at the time of diagnosis and prognostic factors in patients who have failed on optimal traditional therapies-all strategies to guide the cost-effective use of modern therapies. Prediction rules have been developed that are sensitive and specific, but many are limited by their complexity or the need for biomarkers that will never be routinely measured in the clinic. Most rules to date have therefore failed to have a major impact on clinical practice. Probably most interesting is the prediction of response to therapy based upon early treatment response, with outcomes at as early as 3 months predicting response at 12 months. Further work is needed, however, to identify the efficacy of current therapies in preventing disease onset and the long-term cost-effectiveness of appropriately targeted treatment with biologics.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Conaghan PGdoi
10.1007/s10067-010-1639-4subject
Has Abstractpub_date
2011-03-01 00:00:00pages
S41-7eissn
0770-3198issn
1434-9949journal_volume
30 Suppl 1pub_type
杂志文章,评审abstract::The aim of this study was to ascertain whether fibromyalgia patients with positive ANA develop other features of connective tissue disease over 2-4 years' follow-up. Patients attending our clinic with a diagnosis of fibromyalgia were identified. All ANA-positive patients (n = 12) were recruited and matched for age and...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200118
更新日期:2002-11-01 00:00:00
abstract::The thermographic appearance of the sacro-iliac joints in health and in active inflammation has been established on the basis of 72 thermographic examinations of healthy volunteers and 82 examinations of patients with clinically and radiographically active disease. In the latter group a certain number of cases showed ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031895
更新日期:1985-12-01 00:00:00
abstract::The objective of the current work is to report our preliminary experience with the mizoribine (MZR) intermittent pulse protocol for induction therapy for newly diagnosed pediatric-onset systemic lupus erythematosus (SLE). Five consecutive patients who were newly diagnosed as having SLE with biopsy-proven lupus nephrit...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10067-007-0635-9
更新日期:2008-01-01 00:00:00
abstract::The original published version of this article contained the incorrect Table 2 and are now presented correctly in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-020-04926-7
更新日期:2020-04-01 00:00:00
abstract::Ochronotic spondyloarthropathy is a rare metabolic disease with the musculoskeletal manifestations of alkaptonuria. Ochronotic arthropathy patients may have spinal abnormalities similar to ankylosing spondylitis (AS). The proof of sacroiliac involvement or bamboo spine appearance is not sufficient either for diagnosis...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0038-8
更新日期:2006-07-01 00:00:00
abstract::Azathioprine (AZA) is indicated for the treatment of systemic lupus erythematosus (SLE). Thiopurine methyltransferase (TPMT) is the rate-limiting enzyme in the steps of AZA metabolization. Heritable deficiency of TPMT enzyme activity and polymorphisms may lead to leukopenia. This study aims to detect TPMT polymorphism...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2441-x
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:This study aimed to identify the clinical characteristics of systemic lupus erythematosus-primary biliary cholangitis (SLE-PBC) patients and to compare the manifestations and prognosis with systemic lupus erythematosus (SLE) patients. METHODS:Twenty-one inpatients with concomitant SLE and primary biliary cho...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05457-x
更新日期:2020-10-16 00:00:00
abstract::In order to study the function of polymorphonuclear leukocytes in patients suffering from psoriatic and rheumatoid arthritis and psoriasis vulgaris the release of beta-glucuronidase, elastase and cytoplasmic lactate dehydrogenase was investigated. The life of polymorphonuclear leukocytes in rheumatoid and psoriatic ar...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031274
更新日期:1984-12-01 00:00:00
abstract::Beliefs about the unacceptability of experiencing and expressing emotions have been found to be related to worse outcomes in people with persistent physical symptoms. The current study tested mediation models regarding emotional suppression, beliefs about emotions, support-seeking and global impact in fibromyalgia. On...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3590-0
更新日期:2017-05-01 00:00:00
abstract::Although a number of reports have now described an association between polymorphism of the LMP2 gene and disease phenotype in HLA-B27 positive individuals with ankylosing spondylitis (AS), some describe associations with acute anterior uveitis, others with juvenile onset disease, and one report provides no association...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02238938
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the interrelationship between the micro- and macrovasculature. METHODS:This is a cross-sectional study that examined SSc patients and fibromyalgia (FM) patients as controls. We assessed forearm peripheral vascular status and nailfold capillaroscopy. We evaluated the assoc...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05025-3
更新日期:2020-09-01 00:00:00
abstract::To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patient...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208026
更新日期:1991-03-01 00:00:00
abstract::Bone loss in patients with rheumatoid arthritis (RA) varies at different skeletal sites. The aim of the study was to evaluate whether bone mineral density (BMD) of the forearm is significantly different in patients with RA and controls and may correlate to BMD or other parameters of inflammation or bone resorption. We...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1211-2
更新日期:2009-10-01 00:00:00
abstract::PFAPA syndrome is characterized by episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. PFAPA syndrome usually begins in children under 5 years old and normally has self-resolution. The etiology of PFAPA syndrome remains unknown. In this paper, we report the cases of two different famil...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1222-z
更新日期:2009-10-01 00:00:00
abstract::The objective of this study was to describe ultrasonography (US) and magnetic resonance imaging (MRI) findings at painful Achilles tendons and entheses in patients with and without spondyloarthropathy (SpA and non-SpA) and healthy control persons (CTRLs). Particularly, we aimed to investigate if any changes differenti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2111-4
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Visfatin is an adipokine and has a crucial role in pro-inflammatory response. The aim of this study was investigating the visfatin levels of gingival crevicular fluid (GCF) in patients with systemic lupus erythematosus (SLE) and chronic periodontitis and healthy subjects. MATERIALS AND METHODS:Sixty non-obe...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04708-w
更新日期:2019-11-01 00:00:00
abstract::The aims of our study are to observe the pregnancy outcome of anti-Sjögren's syndrome-related antigen A (SSA)/Ro-positive women and to predict the risk factors for adverse pregnancy outcome and neonatal lupus erythematosus (NLE). Clinical data of 126 anti-SSA/Ro-positive patients with 140 pregnancies were evaluated re...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3050-7
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS:In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Dem...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05094-4
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal tract, and kidney involvement. Microribonucleic acids (miRNAs) are 18-25 base-long non-coding RNA group acting on gene expression. They ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05441-5
更新日期:2020-10-10 00:00:00
abstract::A pair of identical twins suffering from ankylosing spondylitis is reported. One brother developed an earlier-onset disease and showed ossification of the posterior longitudinal ligament and the flavum ligament in his cervical spine. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02249033
更新日期:1994-06-01 00:00:00
abstract::Reactive arthritis (ReA) due to Gram-negative intestinal bacteria or Chlamydia, is associated by an unknown mechanism with HLA-B27. Like other MHC class I molecules, HLA-B27 presents antigenic peptides derived from intracellular proteins to CD8+ cytotoxic T cells (CTL). In humans however, CTL specific for ReA associat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF03342653
更新日期:1996-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3282-1
更新日期:2016-11-01 00:00:00
abstract::The aim of this study was to evaluate the relationship between historical height loss (HHL) and prevalent vertebral fractures (VF) in postmenopausal Moroccan women and to estimate its accuracy as a clinical test for detecting VF. Two hundred eighty-eight postmenopausal women were studied. All subjects had bone density...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1236-6
更新日期:2009-11-01 00:00:00
abstract::To describe clinical and epidemiological data of Behçet's disease (BD) in Brazil, we retrospectively reviewed records of all patients seen between 2006 and 2007 at the BD outpatient clinic of University of Sao Paulo. One hundred and six patients fulfilled the International Study Group for Behçet's Disease diagnostic c...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-1081-z
更新日期:2009-05-01 00:00:00
abstract::To present the clinical and pathological findings in patients presenting with myositis caused by syphilis. The literature is reviewed, and pathophysiologic factors discussed. A 49-year-old Caucasian heterosexual male with a known history of stable human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection, ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1668-z
更新日期:2011-05-01 00:00:00
abstract::This study aims to explore the effectiveness of low dose of etanercept (ETN) in patients with ankylosing spondylitis (AS) who achieve a good control of their disease in daily clinical practice. This is a case series of AS patients treated with ETN. According to the judgment of the treating rheumatologist and patient's...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1722-5
更新日期:2011-07-01 00:00:00
abstract::Systemic sclerosis (SS) alters smooth muscle function throughout the gastrointestinal tract, the oesophagus being the segment most often involved. Involvement of the colon, though less common, may lead to life-threatening complications. We studied 23 unselected patients with SS and 20 age-matched healthy controls usin...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s100670170038
更新日期:2001-01-01 00:00:00
abstract::The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 month...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3911-3
更新日期:2018-02-01 00:00:00
abstract::Mouth and genital ulcer with inflamed cartilage syndrome (MAGIC syndrome) is a rare autoinflammatory disorder with unknown etiology. Except for the common clinical manifestations mimicking Behçet's disease and relapsing polychondritis, some other clinical entities are occasionally observed. In this report, we present ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05384-x
更新日期:2020-09-11 00:00:00
abstract::Bacteroides fragilis is a rare cause of septic arthritis. Most patients with B. fragilis septic arthritis have a chronic joint disease, particularly rheumatoid arthritis, and sources of infection are lesions of the gastrointestinal tract and the skin. We report a 69-year-old male, who developed B. fragilis septic arth...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02247808
更新日期:1997-11-01 00:00:00