A meta-analysis to determine the effect of pharmacological and non-pharmacological treatments on fibromyalgia symptoms comprising OMERACT-10 response criteria.

Abstract:

:Fibromyalgia is characterized by widespread pain, sleep problems, fatigue, functional impairment, psychological distress, and cognitive dysfunction. The objective of this meta-analysis is to synthesize the available data on the effectiveness of pharmacological and non-pharmacological interventions across all domains included in the Outcome Measures in Rheumatology Clinical Trials (OMERACT-10) fibromyalgia response definitions, and to examine response based on these definitions. We searched Cochrane, PubMed, Scopus, and the reference lists of articles for randomized controlled trials of any drug formulation or non-pharmacological intervention used for fibromyalgia treatment. We extracted efficacy data regarding pain, sleep, physical function, fatigue, anxiety, depression, and cognition. The available data were insufficient to draw definite conclusions regarding response. Indirect evidence indicates that it may be expected with the use of serotonin noradrenaline reuptake inhibitors (SNRIs), noradrenaline reuptake inhibitors (NRIs), and multidisciplinary treatment.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Papadopoulou D,Fassoulaki A,Tsoulas C,Siafaka I,Vadalouca A

doi

10.1007/s10067-015-3144-2

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

573-86

issue

3

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-015-3144-2

journal_volume

35

pub_type

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