Abstract:
:We report a patient with idiopathic portal hypertension (IPH) associated with systemic sclerosis (SSc) and Sjögren's syndrome. A 72-year-old Japanese woman was admitted to our hospital because of Raynaud's phenomenon, sclerodactyly, and dyspnea. The patient had splenomegaly, esophageal varices in the absence of extrahepatic portal obstruction, and cirrhosis of the liver. Immunological studies revealed positive anti-nuclear antibodies and high titers of anti-Scl-70, anti-SS-A, anti-centromere, and anti-mitochondrial M2 antibodies. Histological examinations of the liver biopsy specimen revealed stenosis and loss of small portal veins without findings of primary biliary cirrhosis. The patient was diagnosed as having IPH associated with SSc and Sjögren's syndrome. These observations suggest an immunological role in the pathogenesis of IPH.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Kogawa H,Migita K,Ito M,Takii Y,Daikoku M,Nakao M,Miyashita T,Kimura H,Ezaki H,Nakamura M,Yatsuhashi H,Eguchi K,Ishibashi Hdoi
10.1007/s10067-005-1084-ysubject
Has Abstractpub_date
2005-09-01 00:00:00pages
544-7issue
5eissn
0770-3198issn
1434-9949journal_volume
24pub_type
杂志文章abstract::This paper presents the first reported case of risedronate-associated scleritis and conducts a review of bisphosphonates and inflammatory eye diseases. A case of scleritis associated with risedronate use in a 73-year-old Chinese woman is reported. The English medical literature was reviewed for bisphosphonates and the...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2035-z
更新日期:2012-09-01 00:00:00
abstract::Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02229707
更新日期:1996-05-01 00:00:00
abstract::Although peripheral blood eosinophilia is observed in patients with active inflammatory rheumatoid arthritis (RA), RA is not a recognised cause of pulmonary eosinophilia. We describe a 55-year-old woman affected by chronic eosinophilic pneumonia (CEP) concomitantly with an initiation of RA. Both diseases responded rap...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0703-8
更新日期:2003-09-01 00:00:00
abstract::We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with ster...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050131
更新日期:1999-01-01 00:00:00
abstract::The use of biotechnology-derived medicines has significantly increased in recent decades. Although biosimilars undergo rigorous characterization as well as clinical studies to document their safety and effectiveness, they are highly complex molecules and small changes in the purification and production process of a bi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-2887-0
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:This study examined whether phase angle (PhA) is associated with hip osteoarthritis (HOA) severity and quadriceps strength in patients with HOA. METHOD:A series of 549 patients with HOA, obtained from the Screening for People Suffering Sarcopenia in the Orthopedic cohort of Kobe study, were ana...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05419-3
更新日期:2020-09-29 00:00:00
abstract::Acetabular protrusion (PA) as measured by a line crossing method was studied in 73 patients with juvenile rheumatoid arthritis (JRA) and its frequency found to be 12% (9/73), presenting bilaterally in 5 cases and unilaterally in 4. All patients had some other forms of radiological damage and the presence of PA was pre...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231556
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:This study was conducted to assess the safety and efficacy of intra-articular injection of etanercept and compare it with corticosteroid injection in rheumatoid arthritis (RA) patients. METHODS:Fifty patients with RA who suffered from activity in one joint were randomized into two groups, received an intra-...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05235-9
更新日期:2021-02-01 00:00:00
abstract::We investigated some steps in the signal transduction pathway leading to the proliferation of synovial cells. 12-o-tetradecanoyl phorbol-13-acetate (TPA) which is known to stimulate phospholipid- and Ca(2+)-dependent protein kinase (C-kinase) enhanced the proliferation of synovial cells. The proliferation of synovial ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207092
更新日期:1992-03-01 00:00:00
abstract::The original version of this article contained error. Table 1 was shown in the wrong version, thus corrected table is shown in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-019-04480-x
更新日期:2019-06-01 00:00:00
abstract::This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n=90) were included prospectively and followed up ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2569-3
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Psoriatic arthritis (PsA) is an inflammatory disorder affecting the joints of psoriatic patients. Gelsolin regulated the actin assembly and disassembly. Reduction in plasma gelsolin levels was detected in tissue damages, including trauma, sepsis, and chronic inflammatory disorders. OBJECTIVES:The study aims...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-04959-y
更新日期:2020-06-01 00:00:00
abstract::The above article originally published with an error present in Table 2 and is now presented correctly in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4280-2
更新日期:2018-10-01 00:00:00
abstract::Tumour necrosis factor alpha (TNF alpha) and interleukin-2 (IL-2) are potential immunological mediators of pathogenetic changes in rheumatoid arthritis. We measured the concentrations of TNF alpha and IL-2 in plasma from 2 groups of patients suffering from rheumatoid arthritis (RA). One group had high and one had low ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206655
更新日期:1991-12-01 00:00:00
abstract::Upper lobe fibrobullous disease is a well-known finding in advanced stages of ankylosing spondylitis (AS). In this report, we present a 57-year-old male patient who was diagnosed with a right apical cavitary lesion after coming to us with the complaint of haemoptysis. The patient underwent upper lobe segmentectomy and...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-004-1047-8
更新日期:2005-08-01 00:00:00
abstract::To compare Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA) with PCP in patients with non-RA connective tissue diseases (CTDs) in order to clarify the characteristics of the former. We extracted consecutive patients satisfying the following criteria for "clinical PCP": (1) positive plasma β-D-gl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4157-4
更新日期:2018-08-01 00:00:00
abstract::In the midst of the COVID-19 pandemic, further understanding of its complications points towards dysregulated immune response as a major component. Systemic lupus erythematosus (SLE) is also a disease of immune dysregulation leading to multisystem compromise. We present a case of new-onset SLE concomitantly with COVID...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05310-1
更新日期:2020-09-01 00:00:00
abstract::Patients with Rheumatic diseases (RDs) are at an increased risk of malignancies compared with the general population. The aim of this study was to examine the relative frequency of several cancers in a single homogeneous cohort of patients with different RDs. Patients diagnosed with rheumatoid arthritis (RA), Ankylosi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3676-8
更新日期:2018-01-01 00:00:00
abstract::Innate immunity has been widely accepted as one of the major cause for the alteration of immune system and progression of autoimmune diseases. Natural killer (NK) cells and natural killer T (NKT) cells have not been explored in clinical studies for their cytolytic components in association with rheumatoid arthritis (R...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2641-z
更新日期:2014-08-01 00:00:00
abstract::Adult-onset Still's disease (AOSD) has often been regarded as the adult spectrum of systemic juvenile idiopathic arthritis (sJIA). The present study aims to compare the clinical and laboratory features, the disease course and the response to treatment in patients having AOSD with those having sJIA. Retrospective revie...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-005-0138-5
更新日期:2006-09-01 00:00:00
abstract::We investigated, in retrospect, if there were differences in the frequency and types of abdominal surgery between newly diagnosed female fibromyalgia (n = 80) and rheumatoid arthritis (n = 47) patients performed before the formal diagnosis. There was no difference in the total number of abdominal operations between bo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050042
更新日期:1999-01-01 00:00:00
abstract::A case of left brachial plexus compression by an iatrogenic arteriovenous fistula was treated by detachable balloon technique with immediate relief of pain. Good results on paresia were obtained in a few weeks. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02330599
更新日期:1987-12-01 00:00:00
abstract::Determine the effect of daily low divided or single daily dose of prednisone on the longitudinal change in the number of tender and swollen joints and HAQ scores in African Americans (AA) with early rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-017-3943-8
更新日期:2018-02-01 00:00:00
abstract::This cross-sectional investigation examined the prevalence and severity of dysphonia, globus pharyngeus, and dysphagia in patients affected by immunomediated (IM) diseases. Seventy subjects were administered the Voice Handicap Index (VHI) (scale 0-4), Glasgow-Edinburgh Throat Scale (GETS) (scale from 0 to 7) for globu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4129-8
更新日期:2019-01-01 00:00:00
abstract::Infection is a major cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). To describe the pattern of serious infections in patients with SLE and to identify the predictors of infection-related mortality among SLE patients with serious infections, we prospectively studied all SLE pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4102-6
更新日期:2018-08-01 00:00:00
abstract::Antiglomerular basement membrane antibody disease (aGD) remains a very uncommon entity in the pediatric population, characterized by pulmonary hemorrhage, glomerulonephritis, and antibodies against the glomerular basement membrane. We herein describe the case of a 14-year-old girl with primary pulmonary symptoms diagn...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2062-9
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:Our aim was to investigate the prevalence value of a high-avidity antinuclear antibody (ANA) of the IgG isotype (HA IgG ANA) compared with that of ANAs of other isotypes in patients with systemic lupus erythematosus (SLE) and to assess the associations of HA IgG ANA with the activity of SLE and lupus nephrit...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05040-4
更新日期:2020-09-01 00:00:00
abstract::Azathioprine (AZA) is indicated for the treatment of systemic lupus erythematosus (SLE). Thiopurine methyltransferase (TPMT) is the rate-limiting enzyme in the steps of AZA metabolization. Heritable deficiency of TPMT enzyme activity and polymorphisms may lead to leukopenia. This study aims to detect TPMT polymorphism...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2441-x
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:Interstitial lung disease (ILD) is frequent and highly disabling in systemic sclerosis (SSc). Magnetic resonance imaging (MRI) is not routinely used to evaluate the lung, due to poorer spatial resolution compared to high-resolution computed tomography (HRCT). We aimed to compare lung MRI signal ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05491-9
更新日期:2020-11-07 00:00:00
abstract::The aim of this study was to investigate the clinical features, risk factors, and outcomes of septic arthritis in patients on maintenance hemodialysis (HD). We systematically reviewed medical records of 16 HD patients with septic arthritis admitted to our hospital from April 2008 to April 2018. A total of 16 HD in pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05114-3
更新日期:2020-10-01 00:00:00