Bleomycin-induced scleroderma: report of a case with a chronic course rather than the typical acute/subacute self-limiting form.

Abstract:

:We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Passiu G,Cauli A,Atzeni F,Aledda M,Dessole G,Sanna G,Nurchis P,Vacca A,Garau P,Laudadio M,Mathieu A

doi

10.1007/s100670050131

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

422-4

issue

5

eissn

0770-3198

issn

1434-9949

journal_volume

18

pub_type

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