Outcomes of dose reduction, withdrawal, and restart of tofacitinib in patients with rheumatoid arthritis: a prospective observational study.

abstract：:Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system and that measures of hearing may be related to indices of RA disease activity. The aims of this study were to determine whether hearing loss in young subjects with rheumatoid ar...

journal_title：Clinical rheumatology

authors： Murdin L,Patel S,Walmsley J,Yeoh LH

更新日期：2008-05-01 00:00:00

abstract：:Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement mol...

journal_title：Clinical rheumatology

authors： Monticielo OA,Mucenic T,Xavier RM,Brenol JC,Chies JA

更新日期：2008-04-01 00:00:00

abstract：:In addition to the debilitating fatigue, the majority of patients with chronic fatigue syndrome (CFS) experience chronic widespread pain. These pain complaints show the greatest overlap between CFS and fibromyalgia (FM). Although the literature provides evidence for central sensitization as cause for the musculoskelet...

journal_title：Clinical rheumatology

authors： Meeus M,Nijs J

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To determine incidence of increased levels of alanine transferase (ALT) >2× upper limit of normal (ULN) in patients receiving methotrexate (MTX), treated according to a dynamic strategy, and to identify predictors of ALT of >2× ULN. METHODS:Data of 508 recent-onset rheumatoid arthritis (RA) patients from the...

journal_title：Clinical rheumatology

authors： Dirven L,Klarenbeek NB,van den Broek M,van Groenendael JH,de Sonnaville PB,Kerstens PJ,Huizinga TW,Dijkmans BA,Lems WF,Allaart CF

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to evaluate clinical remission and MDA in PsA patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Concomitant therapies as well as comorbidities were assessed. Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also...

journal_title：Clinical rheumatology

authors： Chimenti MS,Triggianese P,Conigliaro P,Tonelli M,Gigliucci G,Novelli L,Teoli M,Perricone R

更新日期：2017-10-01 00:00:00

abstract：:While fibromyalgia is frequently associated with ear-related symptoms such as feeling of ear fullness, earache, and tinnitus, the pathogenesis of these ear-related symptoms in fibromyalgia patients is unknown. Here, we focused on clarifying the pathogenesis of ear fullness, a particularly common symptom observed in fi...

journal_title：Clinical rheumatology

authors： Iikuni F,Nomura Y,Goto F,Murakami M,Shigihara S,Ikeda M

更新日期：2013-10-01 00:00:00

abstract：:Inflammation of one or both sacroiliac joints is a characteristic feature of patients with spondyloarthropathies (SpA). Sacroiliitis often leads to inflammatory back pain (IBP). IBP and asymmetric peripheral arthritis of the lower limbs are the main clinical symptoms and criteria for classification and diagnosis of Sp...

journal_title：Clinical rheumatology

authors： Braun J,Sieper J,Bollow M

更新日期：2000-01-01 00:00:00

abstract：:Joint lavage for knee osteoarthritis is an invasive procedure that can be stressful and painful. We aimed to assess the impact of music therapy on perioperative anxiety, pain and tolerability of the procedure in patients undergoing joint lavage performed with two needles. We randomized all patients diagnosed with knee...

journal_title：Clinical rheumatology

authors： Ottaviani S,Bernard JL,Bardin T,Richette P

更新日期：2012-03-01 00:00:00

abstract：:Increased IFN-γ levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-γ, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-tim...

journal_title：Clinical rheumatology

authors： Liu M,Liu J,Hao S,Wu P,Zhang X,Xiao Y,Jiang G,Huang X

更新日期：2018-10-01 00:00:00

abstract：:Bone loss in patients with rheumatoid arthritis (RA) varies at different skeletal sites. The aim of the study was to evaluate whether bone mineral density (BMD) of the forearm is significantly different in patients with RA and controls and may correlate to BMD or other parameters of inflammation or bone resorption. We...

journal_title：Clinical rheumatology

authors： Franck H,Gottwalt J

更新日期：2009-10-01 00:00:00

abstract：:The clinical response to traditional disease-modifying anti-rheumatic drugs (DMARDs) in indigent South Africans with early rheumatoid arthritis was investigated. A cohort of patients with early (≤2 years) RA who were DMARD-naïve at inception were prospectively assessed for response to DMARDs using the Simplified Disea...

journal_title：Clinical rheumatology

authors： Hodkinson B,Musenge E,Ally M,Meyer PW,Anderson R,Tikly M

更新日期：2012-04-01 00:00:00

abstract：:Muscle pain and weakness in a rheumatoid arthritis (RA) patient has a broad differential, and myositis should be considered early in the disease course as serious limb and life-threatening sequelae may occur. A 55-year-old woman with a past medical history of methotrexate-controlled RA presented with right leg pain fo...

journal_title：Clinical rheumatology

authors： Jo D,Pompa T,Khalil A,Kong F,Wetz R,Goldstein M

更新日期：2015-10-01 00:00:00

abstract：:In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of met...

journal_title：Clinical rheumatology

authors： Ravelli A,Viola S,Ramenghi B,Di Fuccia G,Ruperto N,Zonta L,Martini A

更新日期：1995-05-01 00:00:00

abstract：:B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of pat...

journal_title：Clinical rheumatology

authors： Nakiri Y,Minowa K,Suzuki J,Mitsuo A,Amano H,Morimoto S,Tokano Y,Takasaki Y

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS:In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Dem...

journal_title：Clinical rheumatology

authors： Chi H,Jin H,Wang Z,Feng T,Zeng T,Shi H,Wu X,Wan L,Teng J,Sun Y,Liu H,Cheng X,Ye J,Hu Q,Zhou Z,Gu J,Jia J,Liu T,Qiao X,Yang C,Su Y

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:(1) Development and validation of a composite ultrasound score (cUSS) for the diagnosis of carpal tunnel syndrome (CTS). (2) To predict treatment response after local corticosteroid injection. METHODS:Wrists of CTS patients and controls were evaluated with high-resolution ultrasound and cross-sectional area...

journal_title：Clinical rheumatology

authors： Goswami RP,Sit H,Chatterjee M,Lahiri D,Sircar G,Ghosh P

更新日期：2020-07-21 00:00:00

abstract：INTRODUCTION:Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal tract, and kidney involvement. Microribonucleic acids (miRNAs) are 18-25 base-long non-coding RNA group acting on gene expression. They ...

journal_title：Clinical rheumatology

authors： Cebi AH,Demir F,Ikbal M,Kalyoncu M

更新日期：2020-10-10 00:00:00

abstract：:Ochronosis involves primarily the large cartilaginous joint surfaces, ribs, intervertebral discs, ear cartilage etc. We report on a 53-year-old woman with typical alkaptonuric ochronosis with dark urine, blue-black pigmentation of the auriculae and hands, focal brown hyperpigmentation of the sclera, spondylarthropathy...

journal_title：Clinical rheumatology

authors： Nas K,Gür A,Akdeniz S,Cevik R,Harman M,Saraç AJ

更新日期：2002-05-01 00:00:00

abstract：:IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...

journal_title：Clinical rheumatology

authors： Wang B,Tang Y,Sun X,Ouyang X,Li H,Wei J,Zhang Y,Li X

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression of targeted mRNAs, which are important in the pathogenesis of autoimmune diseases. MiRNAs may have the potential to serve as biomarkers of disease. We evaluated serum levels of selected miRNAs and their associations with disease activity in juvenile ...

journal_title：Clinical rheumatology

authors： Kamiya Y,Kawada J,Kawano Y,Torii Y,Kawabe S,Iwata N,Ito Y

更新日期：2015-10-01 00:00:00

abstract：:Initial treatment of trapeziometacarpal osteoarthritis (TMO) often consists of intra-articular injection of corticosteroids or hyaluronic acid. Several studies have shown that ultrasound (US)-guided injections demonstrate greater precision and effectiveness when compared to blind techniques. The aim of our study was t...

journal_title：Clinical rheumatology

authors： Di Sante L,Cacchio A,Scettri P,Paoloni M,Ioppolo F,Santilli V

更新日期：2011-09-01 00:00:00

abstract：:The aim of this study is to assess the gender differences in spondyloarthritides (SpAs) in terms of disease onset, clinical presentation, and the Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI). We analysed data from a predominantly female cohort. Five hundred and 16 patients (ma...

journal_title：Clinical rheumatology

authors： Roussou E,Sultana S

更新日期：2011-01-01 00:00:00

abstract：:Joint hypermobility syndrome (JHS) is common in patients presenting to rheumatologists and can cause a range of symptoms leading to physical and psychological distress. Chronic musculoskeletal pain in patients with JHS often responds poorly to analgesics, and a pain management approach may be helpful. Since patients w...

journal_title：Clinical rheumatology

authors： Rahman A,Daniel C,Grahame R

更新日期：2014-11-01 00:00:00

abstract：:CD30/CD30L and CD40/CD40L are molecules from the tumor necrosis factor (TNF) superfamily. They have a major effect on communications between the B and T cells, which leads to control of maturation, proliferation, and apoptosis of those cells. The aim of this study was to compare the levels of a soluble form of CD30 (s...

journal_title：Clinical rheumatology

authors： Ciferská H,Horák P,Hermanová Z,Ordeltová M,Zadrazil J,Tichý T,Scudla V

更新日期：2007-05-01 00:00:00

abstract：:The aim of our study was to explore the relationship between circulating T cells and ankylosing spondylitis (AS) and to find the role of the CD8+CD122+ T cells in the pathogenesis and progression of AS. With the method of case-control design, flow cytometry was performed to quantitatively determine the percentage of c...

journal_title：Clinical rheumatology

authors： Han R,Yang X,Chen M,Zhang X,Yuan Y,Hu X,Wang M,Liu R,Ma Y,Yang J,Xu S,Shuai Z,Jiang S,Pan F

更新日期：2018-03-01 00:00:00

abstract：:Gastrointestinal tract (GIT) is the most common organ system involved in systemic sclerosis (SSc). GIT involvement is mainly attributed to GIT dismobility and wide mouth diverticular. GIT involvement in SSc can be also severely debilitating and even life threatening. To our knowledge, the presence of gastrointestinal ...

journal_title：Clinical rheumatology

authors： Plastiras SC,Tzivras M,Vlachoyiannopoulos PG

更新日期：2007-06-01 00:00:00

abstract：:We present a patient with previously diagnosed hypocomplementemic urticarial vasculitis syndrome, with skin, lung, and renal involvement, who presented with congestive cardiac failure. During the course of her hospitalization, she was also found to have profound proximal muscle weakness in both upper and lower limbs a...

journal_title：Clinical rheumatology

authors： Chew GY,Gatenby PA

更新日期：2007-08-01 00:00:00

abstract：:In an open study, we have assessed the bone/soft tissue uptake index in recent osteoporotic vertebral collapse using scintigraphy. The evolution of these cases was followed-up at 6 months in 22 patients treated with 100 IU of salmon calcitonin plus 500 mg of elemental calcium/10 days per month and in 18 patients treat...

journal_title：Clinical rheumatology

authors： Rico H,Merono E,Del Olmo J,Revilla M

更新日期：1991-09-01 00:00:00

abstract：:Catastrophic anti-phospholipid syndrome (CAPS) is a medical emergency characterized by thromboses of multiple small vessels of internal organs and the brain. Herein we present a patient with primary anti-phospholipid syndrome who developed CAPS manifested by hepatic, renal and splenic artery thromboses, as well as cer...

journal_title：Clinical rheumatology

authors： Zeller L,Almog Y,Tomer A,Sukenik S,Abu-Shakra M

更新日期：2006-05-01 00:00:00

abstract：:Cytokine gene loci are one of the potential susceptibility factors in immuno-inflammatory diseases. Interleukin1 (IL-1) is a major monocyte derived proinflammatory cytokine that mediates tissue damage and cartilage loss in chronic arthritis. IL-1 locus has been linked to various autoimmune diseases, but data on juveni...

journal_title：Clinical rheumatology

authors： Aggarwal A,Srivastava R,Singh S,Kumar Dubey P

更新日期：2012-04-01 00:00:00