Abstract：
:Up to now, there is no uniformly accepted treatment for avascular necrosis (AN) that alleviates pain and retards its progression. The aim of clinical and surgical treatments is usually only to improve blood support in the avascular area. The objective of the present study was to make a systematic review of the use of bisphosphonates in the treatment of AN. Studies in which bisphosphonate was used for the treatment of AN were researched through the MEDLINE databases (from 1966 to 2007) and the Cochrane Central Register of Controlled Trials and using the following terms: "avascular necrosis," "aseptic necrosis," "bisphosphonates," "alendronate," "pamidronate," "zoledronate," and "risedronate". Only seven articles that met the previously established criteria were obtained from MEDLINE, and none were obtained from the Cochrane Central Register of Controlled Trials. Of these seven articles, two were randomized clinical trials and five were prospective comparative studies; one of them corresponded to an extension of a previous study. The present review demonstrates that there are no controlled and double-blind studies about the efficacy of bisphosphonates in the treatment of AN. Therefore, the data are still insufficient for justifying its use for this indication. On the other hand, noncontrolled studies appear to demonstrate favorable results, particularly in diminishing pain, improving mobility, and lowering the incidence of articular collapse, which justifies new studies being developed in this area.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Cardozo JB,Andrade DM,Santiago MBdoi
10.1007/s10067-008-0861-9subject
Has Abstractpub_date
2008-06-01 00:00:00pages
685-8issue
6eissn
0770-3198issn
1434-9949journal_volume
27pub_type
杂志文章,评审abstract：:The aim of this blinded, randomised, multicentre study was to compare the tolerability of aspirin, paracetamol and ibuprofen in common pain resulting from musculoskeletal conditions (MSC) in general practice with patients with other non-MSC pain conditions. Patients took aspirin, paracetamol (both up to 3g daily) or i...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s100670200007
更新日期：2002-02-01 00:00:00
abstract：:We report a young male with recent onset of rheumatoid arthritis (RA) in whom the remarkable severity of the disease led to additional investigations. The only significant finding was mediastinal lymphadenopathy, without lung involvement. Biopsy of the mediastinal lymph node revealed pathological findings typical of s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-002-0639-4
更新日期：2003-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01452269
更新日期：1998-01-01 00:00:00
abstract：:Churg-Strauss syndrome (CSS) is a rare, systemic, necrotizing, small- and middle-sized vessel vasculitis which is accompanied by blood eosinophilia, eosinophil infiltration of various tissues, and bronchial asthma. The lungs are the organs most often involved in CSS. The aim of this study was a retrospective evaluatio...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1530-3
更新日期：2010-10-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3868-2
更新日期：2017-12-01 00:00:00
abstract：:This study aimed to investigate the multiple values of 18F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by 18F-FDG PET/CT and eventu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3794-3
更新日期：2017-10-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-016-3511-7
更新日期：2017-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2181-y
更新日期：2013-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-1081-z
更新日期：2009-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031978
更新日期：1990-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2726-8
更新日期：2015-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2565-7
更新日期：2015-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0831-7
更新日期：2008-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-004-1076-3
更新日期：2006-02-01 00:00:00
abstract：:Juvenile systemic lupus erythematosus (JSLE) is a multi-system autoimmune inflammatory disease. Generally, 60% of patients will develop lupus nephritis (LN); thus, early recognition and treatment is associated with better outcome. Interleukin 22 (IL-22) is involved in tissue inflammation and is regulated by interleuki...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3812-5
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04802-z
更新日期：2020-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3658-x
更新日期：2017-09-01 00:00:00
abstract：:2'5'-Oligoadenylate synthetase (OAS) was shown to be related to systemic lupus erythematosus (SLE) 20 years ago, and was rediscovered to be involved in type I interferon pathway in SLE by several microarray gene expression studies recently. The goal of this study was to investigate OAS isoform expressions in lupus pat...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0260-z
更新日期：2007-02-01 00:00:00
abstract：:There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-013-2342-z
更新日期：2013-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3030-y
更新日期：2016-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-013-2425-x
更新日期：2015-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231689
更新日期：1996-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-005-1143-4
更新日期：2006-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0601-6
更新日期：2007-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031268
更新日期：1984-12-01 00:00:00
abstract：:Seventy-nine patients suffering from rheumatoid factor positive rheumatoid arthritis (RA) were included in this study. In each patient disease activity was assessed three times at two-week intervals during a four-week period. All factors that might possibly influence RA, except atmospheric conditions (AC) were held co...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02206665
更新日期：1991-12-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is associated with an increased risk of atherosclerotic cardiovascular disease (ACD). The atherogenic index of plasma (AIP), which is the logarithmic transformation of the plasma triglyceride (TG) level to the high-density lipoprotein level (HDL) ratio, has been suggested to be a novel mark...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4027-0
更新日期：2018-05-01 00:00:00
abstract：:Mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. It is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. This is the first report of septic arthritis with this fungus in a healthy Canadian male. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1448-9
更新日期：2010-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02230334
更新日期：1996-03-01 00:00:00
abstract：:The Revised Fibromyalgia Impact Questionnaire (FIQR) attempts to address the limitations of the Fibromyalgia Impact Questionnaire (FIQ). As there is no Turkish version of the FIQR available, we aimed to investigate the validity and reliability of a Turkish translation of the FIQR in Turkish female fibromyalgia (FM) pa...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1546-8
更新日期：2011-03-01 00:00:00
