Abstract:
:2'5'-Oligoadenylate synthetase (OAS) was shown to be related to systemic lupus erythematosus (SLE) 20 years ago, and was rediscovered to be involved in type I interferon pathway in SLE by several microarray gene expression studies recently. The goal of this study was to investigate OAS isoform expressions in lupus patients, to evaluate whether they could become biomarkers to differentiate between disease flare and infection. Fifty-four SLE patients presented with fever or systemic inflammatory syndrome, or both, were enrolled. Gene expressions of OAS1, OAS2, and OASL were studied by using real time PCR in active SLE (SLEDAI >or=9, n=29) and in those complicated with infections (n=25). The latter group was composed of 19 patients with invasive bacterial infections, and six patients with viral infections. C reactive protein (CRP) and other clinical parameters were also measured. Twenty-nine healthy individuals made up a normal control group. The mRNA expressions of OAS1, OAS2, and OASL were higher in patients with lupus flares than those with infections (p<0.03), or normal controls (p<0.001). SLE complicated with infections have higher OAS1 expression level (P=0.002), lower OASL (P=0.004), and equivalent OAS2 (P=0.135), when compared with those of normal controls. OASL expression level was negatively correlated with infection in lupus by logistic regression analysis (p=0.008). Area under the receiver operating characteristic curve for the prediction of infection was 0.92 (p<0.0001) for OASL, and 0.77 (p=0.007) for CRP. Therefore, our preliminary data suggest that the pattern of OAS isoform expressions, OASL in particular, may provide useful information in differentiating disease flares from certain infections in SLE.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Ye S,Guo Q,Tang JP,Yang CD,Shen N,Chen SLdoi
10.1007/s10067-006-0260-zsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
186-90issue
2eissn
0770-3198issn
1434-9949journal_volume
26pub_type
杂志文章abstract::We describe a case of an 82-year-old woman with giant cell arteritis, who developed unilateral pitting oedema of the dorsum of the right hand, foot and distal part of the right forearm as well as tenosynovitis of the right wrist extensors, mild synovitis of the right wrist, metacarpophalangeal and metatarsophalangeal ...
journal_title:Clinical rheumatology
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3030-y
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journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170112
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2257-8
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pub_type: 杂志文章,已发布勘误
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pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-014-2642-y
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0018-z
更新日期:2006-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030965
更新日期:1986-01-01 00:00:00
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doi:10.1007/s10067-005-0177-y
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4282-0
更新日期:2018-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0890-y
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pub_type: 杂志文章,meta分析
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02242943
更新日期:1994-09-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02114391
更新日期:1990-09-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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doi:10.1007/s100670200106
更新日期:2002-09-01 00:00:00