Abstract:
:We reviewed the records of 315 patients with rheumatoid arthritis (RA) treated with low-dose methotrexate (MTX) and evaluated the conditions contributing to thrombocytopenia. Thirteen out of 315 patients with RA presented with low platelet counts (< or = 100.000/mm3). The age of these patients (51 +/- 12.6 years) did not correlate with thrombocytopenia (r = 0.211, p > 0.05). Thrombocytopenia resulted from coadministration of MTX and NSAID or multiple drug interactions. We observed a significant (r = 0.48, p < 0.05) increase of discontinuation of NSAID's but not of MTX therapy (r = 0.42, p > 0.05) with a mounting weekly dosage of MTX (12.5 +/- 5 mg orally). There was a significant correlation between this weekly dosage of MTX coadministered on the same day with NSAID and thrombocytopenia (r = 0.6, p < 0.05). In most cases (9/13) MTX was not or just temporarily withdrawn. Three of the remaining patients had multiple drug interactions. Reintroduction of low dose MTX treatment in patients having had thrombocytopenia could be performed safely, if thrombocytopenia occurred as a result of concomitant application of MTX and NSAID and no other multiple drug interactions. Preferably, MTX and NSAID should be given to these risk patients on separate days or intervals considering half time clearance of NSAIDs. This procedure has avoided the reoccurrence of thrombocytopenia and controlled further drug interactions of NSAIDs and MTX in our patients.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Franck H,Rau R,Herborn Gdoi
10.1007/BF02230334subject
Has Abstractpub_date
1996-03-01 00:00:00pages
163-7issue
2eissn
0770-3198issn
1434-9949journal_volume
15pub_type
杂志文章abstract::Two cases of systemic lupus erythematosus (SLE) with autoimmune hepatitis are reported. Both patients had a mild form of SLE without central nervous system or renal involvement and showed a rapid response to corticosteroid therapy. Neither of them had antibodies to mitochondria, smooth muscle, and liver/kidney microso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02238968
更新日期:1997-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-012-2026-0
更新日期:2012-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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doi:10.1007/s10067-009-1115-1
更新日期:2009-06-01 00:00:00
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doi:10.1007/s10067-014-2599-x
更新日期:2014-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206850
更新日期:1987-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3647-0
更新日期:2017-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031069
更新日期:1989-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-1987-3
更新日期:2012-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0970-5
更新日期:2008-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030760
更新日期:1984-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1496-1
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-009-1340-7
更新日期:2010-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05573-8
更新日期:2021-01-02 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041395
更新日期:1983-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2035-z
更新日期:2012-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0142-9
更新日期:2007-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3477-5
更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-021-05581-2
更新日期:2021-01-12 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF03342632
更新日期:1995-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170102
更新日期:2001-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-0861-9
更新日期:2008-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02214106
更新日期:1989-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1106-2
更新日期:2009-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-014-2657-4
更新日期:2015-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0978-x
更新日期:2009-01-01 00:00:00