Abstract:
:To evaluate the influence of TNF-α inhibitor on lipid profile and atherogenic index of plasma (AIP) in axial spondyloarthritis (axSpA) patients with long-term use of stable dose TNF-α inhibitor. AxSpA patients were enrolled in the Catholic Axial Spondyloarthritis COhort (CASCO). We collected their data annually and analyzed their lipid profile and AIP. Comparison was conducted between TNF-α inhibitor user group and non-user group. Additionally, lipid profile and AIP of TNF-α inhibitor user group were compared over 2 years. A total of 238 axSpA patients were enrolled for the present study, including 132 TNF-α inhibitor users and 106 non-users. Changes of total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), and HDL-C over 2 years did not show significant difference between TNF-α inhibitor user group and non-user group. When baseline data and 2-year follow-up data were compared within the TNF-α inhibitor user group, there was no significant increase in TG, LDL-C, HDL-C, or AIP. Only TC level was slightly increased in the 2-year follow-up data for the TNF-α inhibitor user group (177.86 ± 28.73 vs. 183.08 ± 29.82, P = 0.019). Long-term use of stable dose TNF-α inhibitor did not increase atherogenic lipid profile or AIP compared to the control group. Furthermore, atherogenic lipid profile or AIP was not increased significantly in the TNF-α inhibitor user group over the 2-year follow-up. Therefore, using TNF-α inhibitor for a long term might not affect atherosclerosis of axSpA.Key Points• Managing risk factors of cardiovascular disease (CVD) such as dyslipidemia in axSpA is important because axSpA patients have increased risk of CVD.• Using TNF-α inhibitor for 2 years with stable dose did not deteriorate atherogenic lipid profile or AIP as predictor of atherosclerosis.• Maintaining stable dose of TNF-α inhibitor for long-term in axSpA may be relatively safe for managing atherogenic lipid.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Min HK,Lee J,Ju JH,Park SH,Kwok SKdoi
10.1007/s10067-019-04767-zsubject
Has Abstractpub_date
2020-02-01 00:00:00pages
471-477issue
2eissn
0770-3198issn
1434-9949pii
10.1007/s10067-019-04767-zjournal_volume
39pub_type
杂志文章abstract::The objectives of this study are to assess the levels of serum Interleukin-35 (IL-35) in patients with idiopathic inflammatory myopathies (IIMs) and to evaluate the association between IL-35 levels and IIM-related features. Serum IL-35 was detected in 76 patients with dermatomyositis (DM), 28 patients with polymyositi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3347-1
更新日期:2016-11-01 00:00:00
abstract::Churg-Strauss syndrome (CSS) is a rare, systemic, necrotizing, small- and middle-sized vessel vasculitis which is accompanied by blood eosinophilia, eosinophil infiltration of various tissues, and bronchial asthma. The lungs are the organs most often involved in CSS. The aim of this study was a retrospective evaluatio...
journal_title:Clinical rheumatology
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doi:10.1007/s10067-010-1530-3
更新日期:2010-10-01 00:00:00
abstract::Total body bone mineral (TBBM) measured by dual photon absorptiometry and local bone mineral (BMC) measured by single photon absorptiometry were determined in 55 patients with definite or classical rheumatoid arthritis. All of them had been on a steady dose of anti-inflammatory drugs for at least 12 months, and furthe...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041401
更新日期:1983-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02042773
更新日期:1982-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041561
更新日期:1983-12-01 00:00:00
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doi:10.1007/s10067-015-3077-9
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pub_type: 杂志文章
doi:10.1007/s10067-007-0706-y
更新日期:2008-03-01 00:00:00
abstract:INTRODUCTION:The frequency of eighth nerve lesions in patients with giant cell arteritis (GCA) has rarely been examined. However, sudden onset deafness has been recorded as a presenting feature of GCA on several occasions. This study sought to establish how common this and other symptoms of eighth nerve involvement are...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04747-3
更新日期:2019-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
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更新日期:1989-06-01 00:00:00
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doi:10.1007/s10067-020-05225-x
更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-013-2220-8
更新日期:2013-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0397-9
更新日期:2007-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-005-0018-z
更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-007-0572-7
更新日期:2007-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-007-0815-7
更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-020-05457-x
更新日期:2020-10-16 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-2908-z
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-018-4130-2
更新日期:2018-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s100670050121
更新日期:1999-01-01 00:00:00
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doi:10.1007/s10067-010-1620-2
更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031895
更新日期:1985-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0753-y
更新日期:2003-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3831-2
更新日期:2018-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3082-z
更新日期:2016-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2014-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-019-04865-y
更新日期:2020-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3812-5
更新日期:2018-02-01 00:00:00