Relationship between local and total bone mineral in patients with rheumatoid arthritis and normal subjects.

Abstract:

:Total body bone mineral (TBBM) measured by dual photon absorptiometry and local bone mineral (BMC) measured by single photon absorptiometry were determined in 55 patients with definite or classical rheumatoid arthritis. All of them had been on a steady dose of anti-inflammatory drugs for at least 12 months, and furthermore, 13 patients were on glucocorticoids. The results were compared with 49 normal persons matched for sex, age and menopausal state. A highly significant correlation was found between BMC and TBBM in the patients (r = 0.84, SEE = 13.0%) as well as in the controls (r = 0.77, SEE 10.5%). Moreover, the intercepts and the slopes were virtually of the same order. Subdividing the patients according to glucocorticoid treatment the same high correlations were shown in the two subgroups. As a group the patients on glucocorticoids had a highly significant generalized osteopenia (a reduction of TBBM of 26% compared to normals). The patients on other anti-inflammatory drugs had a significant, but less pronounced generalized osteopenia (a reduction of TBBM by 11% compared to normals). It is concluded, that BMC of the forearm can be used as a valid estimate of total body calcium in groups of patients with rheumatoid arthritis and in normal subjects.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Skibsted Als O,Gotfredsen A,Christiansen C

doi

10.1007/BF02041401

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

265-71

issue

3

eissn

0770-3198

issn

1434-9949

journal_volume

2

pub_type

杂志文章
  • Theoretical mechanism for the gastrointestinal safety of etodolac: selective sparing of cytoprotective prostaglandins.

    abstract::The high concentrations of pro-inflammatory prostaglandins (PGs) produced in the joint during the initial stage of inflammation can be decreased by inhibiting their biosynthesis with nonsteroidal anti-inflammatory drugs (NSAIDs). The commonly encountered gastrointestinal intolerance in human subjects treated with NSAI...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02214106

    authors: Dvornik D,Lee DK

    更新日期:1989-03-01 00:00:00

  • Multiplex assessment of serum cytokine and chemokine levels in idiopathic morphea and vitamin K1-induced morphea.

    abstract::The levels of 63 cytokines, chemokines, and growth factors were measured in the serum of four patients with idiopathic morphea and of one patient with vitamin K1-induced morphea employing a multiplex assay to identify the role of inflammatory/immunologic events in their pathogenesis. Full-thickness skin biopsies of af...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3580-2

    authors: Cox LA,Webster GF,Piera-Velazquez S,Jimenez SA

    更新日期:2017-05-01 00:00:00

  • Rheumatoid arthritis-related interstitial lung disease (RA-ILD): methotrexate and the severity of lung disease are associated to prognosis.

    abstract::Interstitial lung disease (ILD) is a severe rheumatoid arthritis (RA) manifestation. The worst survival has been associated with usual interstitial pneumonia (UIP) definitive pattern in high-resolution chest tomography (HRCT) scans. Moreover, the use of methotrexate in RA-ILD is controversial. Our aim was to evaluate ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3707-5

    authors: Rojas-Serrano J,Herrera-Bringas D,Pérez-Román DI,Pérez-Dorame R,Mateos-Toledo H,Mejía M

    更新日期:2017-07-01 00:00:00

  • The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.

    abstract::Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-014-2517-2

    authors: Younger J,Parkitny L,McLain D

    更新日期:2014-04-01 00:00:00

  • Tumour necrosis factor alpha and interleukin-2 in plasma from rheumatoid arthritis patients in relation to disease activity.

    abstract::Tumour necrosis factor alpha (TNF alpha) and interleukin-2 (IL-2) are potential immunological mediators of pathogenetic changes in rheumatoid arthritis. We measured the concentrations of TNF alpha and IL-2 in plasma from 2 groups of patients suffering from rheumatoid arthritis (RA). One group had high and one had low ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02206655

    authors: Espersen GT,Vestergaard M,Ernst E,Grunnet N

    更新日期:1991-12-01 00:00:00

  • Efficacy of methylprednisolone pulse therapy in children with rheumatoid arthritis.

    abstract::Pulse therapy is one of the most well-known methods used in the treatment of juvenile rheumatoid arthritis. This study assessed the outcome of methylprednisolone pulse therapy, its rate of efficacy, and its associated complications in patients with juvenile rheumatoid arthritis (JRA). This cross-sectional study was pe...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-0919-8

    authors: Aghighi Y,Attarod L,Javanmard M

    更新日期:2008-11-01 00:00:00

  • Association between rs2431697 T allele on 5q33.3 and systemic lupus erythematosus: case-control study and meta-analysis.

    abstract::rs2431697 is located on 5q33.3, between pituitary tumor-transforming gene 1 and miR-146a. Several studies have estimated the association between rs2431697 and systemic lupus erythematosus risk. However, the results were inconsistent. A case-control study was carried out to explore the association between rs2431697 and...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10067-015-3045-4

    authors: Tang ZM,Wang P,Chang PP,Hasahya T,Xing H,Wang JP,Hu LH

    更新日期:2015-11-01 00:00:00

  • A systematic review of the effect of TNF-alpha antagonists on lipid profiles in patients with rheumatoid arthritis.

    abstract::Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-010-1405-7

    authors: Pollono EN,Lopez-Olivo MA,Lopez JA,Suarez-Almazor ME

    更新日期:2010-09-01 00:00:00

  • Toxicity of antirheumatic and anti-inflammatory drugs in children.

    abstract::The aim of the study was to describe the long-term toxicity of antirheumatic and anti-inflammatory drugs in a paediatric rheumatology clinic population. One hundred and seventeen children were studied on first admission to a paediatric rheumatology clinic and after a mean of 8.6 +/- 0.4 years of follow-up. Medical rec...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF01451288

    authors: Flatø B,Vinje O,Førre O

    更新日期:1998-01-01 00:00:00

  • Anti-cyclic citrullinated peptide antibodies in scleroderma patients.

    abstract::Anti-CCP (cyclic citrullinated peptide) is considered the most useful laboratory tool in the diagnosis of rheumatoid arthritis (RA). Some authors have also found this autoantibody in patients with scleroderma (SSc). The study aimed to investigate the prevalence of anti-CCP antibodies in SSc patients from Southern Braz...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-011-1930-z

    authors: Polimeni M,Feniman D,Skare TS,Nisihara RM

    更新日期:2012-05-01 00:00:00

  • Management of anti-HBc-positive patients with rheumatic diseases treated with disease-modifying antirheumatic drugs-a single-center analysis of 2054 patients.

    abstract::Hepatitis B virus (HBV) reactivation is a common complication of immunosuppressive treatment in high prevalence countries. Biological disease-modifying antirheumatic drugs (bDMARDs) cause this adverse event more often than conventional immunosuppressants. The incidence of HBV reactivation during treatment for rheumati...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4295-8

    authors: Schwaneck EC,Krone M,Kreissl-Kemmer S,Weißbrich B,Weiss J,Tony HP,Gadeholt O,Schmalzing M,Geier A

    更新日期:2018-11-01 00:00:00

  • Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.

    abstract::The objectives of this study are to investigate the prevalence of PAD4 and anti-PAD4 antibodies (Abs) in autoimmune diseases and to clarify their association with anticitrullinated protein antibodies (ACPAs) and shared epitope (SE) in patients with rheumatoid arthritis (RA). Levels of human PAD4 and anti-PAD4 Abs in s...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-3082-z

    authors: Umeda N,Matsumoto I,Kawaguchi H,Kurashima Y,Kondo Y,Tsuboi H,Ogishima H,Suzuki T,Kagami Y,Sakyu T,Ishigami A,Maruyama N,Sumida T

    更新日期:2016-05-01 00:00:00

  • Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis.

    abstract::In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of met...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02208347

    authors: Ravelli A,Viola S,Ramenghi B,Di Fuccia G,Ruperto N,Zonta L,Martini A

    更新日期:1995-05-01 00:00:00

  • Progress made towards enhancement of rheumatology education and practice in Zambia: review of an ILAR-supported project.

    abstract::The burden of non-communicable diseases such as musculoskeletal diseases in the developing world is often overshadowed by the more prevalent infectious diseases. Generally, there is gross underestimation of the burden of rheumatologic disease in the backdrop of scanty or indeed non-existent rheumatology services in th...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-014-2624-0

    authors: Chipeta J,Njobvu P,McGill PE,Bucala R

    更新日期:2014-01-01 00:00:00

  • A comparison of prednisolone with azathioprine and prednisolone with intramuscular gold in rheumatoid arthritis.

    abstract::Pulse prednisolone hemisuccinate therapy (500 mg given intravenously on three occasions over two weeks) has been combined with either intramuscular sodium aurothiomalate or azathioprine in an assessment of 30 patients with rheumatoid arthritis. Significant improvement in a variety of clinical and biochemical assessmen...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02204452

    authors: Häntzschel H,Otto W,Arnold S,Seidel W,Krüger W,Winiecki P,Bird HA,Dixon JS,Astbury G,Wright V

    更新日期:1988-06-01 00:00:00

  • Primary Sjögren's syndrome presenting as hypokalaemic periodic paralysis and respiratory arrest.

    abstract::We report a case of hypokalaemic, flaccid quadriparesis with sudden respiratory arrest in a 27-year-old Japanese woman in whom the discovery of distal renal tubular acidosis led to the diagnosis of primary Sjögren's syndrome (SS). Hypokalaemic periodic paralysis as the initial manifestation of primary SS is rare, but ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670170028

    authors: Fujimoto T,Shiiki H,Takahi Y,Dohi K

    更新日期:2001-01-01 00:00:00

  • The use of bisphosphonate in the treatment of avascular necrosis: a systematic review.

    abstract::Up to now, there is no uniformly accepted treatment for avascular necrosis (AN) that alleviates pain and retards its progression. The aim of clinical and surgical treatments is usually only to improve blood support in the avascular area. The objective of the present study was to make a systematic review of the use of ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-008-0861-9

    authors: Cardozo JB,Andrade DM,Santiago MB

    更新日期:2008-06-01 00:00:00

  • Paget's sarcoma--with two illustrative cases.

    abstract::Two cases of Paget's sarcoma of bone are described. The first one is mainly characterized by the almost simultaneous degeneration of the only two existing locations of the underlying Paget's disease. The second case is one of monostotic Paget's disease of the scapula disclosed by the malignant degeneration. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031268

    authors: Huaux JP,Esselinckx W,Noel H,Grodos J,Nagant de Deuxchaisnes C

    更新日期:1984-12-01 00:00:00

  • Hypothalamus-hypophysis-thyroid axis, triiodothyronine and antithyroid antibodies in patients with primary and secondary Sjögren's syndrome.

    abstract::It has been well established that, anti-thyroglobulin antibodies (ATG) and anti-microsomal antibodies (AMC) may be present in various thyroid disorders and other systemic autoimmune diseases, including Sjögren's syndrome (SS). However, presence of circulating autoantibodies to thyroid hormones, i.e. both to triiodothy...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670170102

    authors: Ozgen AG,Keser G,Erdem N,Aksu K,Gümüsdis G,Kabalak T,Doganavsargil E

    更新日期:2001-01-01 00:00:00

  • Pregnancy outcome of 126 anti-SSA/Ro-positive patients during the past 24 years--a retrospective cohort study.

    abstract::The aims of our study are to observe the pregnancy outcome of anti-Sjögren's syndrome-related antigen A (SSA)/Ro-positive women and to predict the risk factors for adverse pregnancy outcome and neonatal lupus erythematosus (NLE). Clinical data of 126 anti-SSA/Ro-positive patients with 140 pregnancies were evaluated re...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-3050-7

    authors: Luo Y,Zhang L,Fei Y,Li Y,Hao D,Liu Y,Zhao Y

    更新日期:2015-10-01 00:00:00

  • HLA antigens in Yugoslav population with rheumatoid arthritis.

    abstract::The antigens of HLA-DR locus were determined in 127 patients with rheumatoid arthritis and in 175 healthy persons. The frequency of HLA-DR1 antigen was discovered in 45% of the patients and in 22.3% of the examinees from the control group (p less than 0.001). The relative risk is 2.84. 69% of the patients were seropos...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02030241

    authors: Jajić Z,Jajić I,Jajić I,Kerhin-Brkljacic V

    更新日期:1990-03-01 00:00:00

  • Macrophage-colony stimulating factor (M-CSF) is increased in the synovial-like membrane of the periprosthetic tissues in the aseptic loosening of total hip replacement (THR).

    abstract::The aim of the study was to assess the eventual presence, cellular localization and extent of expression of the osteoclast activating cytokine M-CSF (CSF-1) in the periprosthetic tissues around loose total hip replacement (THR). Synovial-like membrane was obtained from the implant-to-bone interface and pseudocapsule f...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02238958

    authors: Xu JW,Konttinen YT,Waris V,Pätiälä H,Sorsa T,Santavirta S

    更新日期:1997-05-01 00:00:00

  • Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.

    abstract::In addition to the debilitating fatigue, the majority of patients with chronic fatigue syndrome (CFS) experience chronic widespread pain. These pain complaints show the greatest overlap between CFS and fibromyalgia (FM). Although the literature provides evidence for central sensitization as cause for the musculoskelet...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-006-0433-9

    authors: Meeus M,Nijs J

    更新日期:2007-04-01 00:00:00

  • Spectrum of infections and outcome among hospitalized South Africans with systemic lupus erythematosus.

    abstract::Our aim was to determine reasons for admission, the prevalence and spectrum of infections, and the outcomes in a multiethnic cohort of hospitalized systemic lupus erythematosus (SLE) patients in Durban, South Africa. We reviewed the records of hospitalized SLE patients seen over a 79-month period; the demographic data...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2847-0

    authors: Dubula T,Mody GM

    更新日期:2015-03-01 00:00:00

  • Lung magnetic resonance imaging in systemic sclerosis: a new promising approach to evaluate pulmonary involvement and progression.

    abstract:INTRODUCTION/OBJECTIVES:Interstitial lung disease (ILD) is frequent and highly disabling in systemic sclerosis (SSc). Magnetic resonance imaging (MRI) is not routinely used to evaluate the lung, due to poorer spatial resolution compared to high-resolution computed tomography (HRCT). We aimed to compare lung MRI signal ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05491-9

    authors: Gargani L,Bruni C,De Marchi D,Romei C,Guiducci S,Bellando-Randone S,Aquaro GD,Pepe A,Neri E,Colagrande S,Falaschi F,Moggi-Pignone A,Pingitore A,Matucci-Cerinic M

    更新日期:2020-11-07 00:00:00

  • Role of dual-energy CT in the diagnosis and follow-up of gout: systematic analysis of the literature.

    abstract::The aim of this systematic review was to determine the potential role of dual-energy CT in the diagnosis and follow-up of gout with regard to the Outcome Measures in Rheumatology (OMERACT) filter. A systematic analysis of the literature was conducted using the MEDLINE and Cochrane databases and published abstracts of ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-017-3976-z

    authors: Ramon A,Bohm-Sigrand A,Pottecher P,Richette P,Maillefert JF,Devilliers H,Ornetti P

    更新日期:2018-03-01 00:00:00

  • Relationship between historical height loss and vertebral fractures in postmenopausal women.

    abstract::The aim of this study was to evaluate the relationship between historical height loss (HHL) and prevalent vertebral fractures (VF) in postmenopausal Moroccan women and to estimate its accuracy as a clinical test for detecting VF. Two hundred eighty-eight postmenopausal women were studied. All subjects had bone density...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1236-6

    authors: Bennani L,Allali F,Rostom S,Hmamouchi I,Khazzani H,El Mansouri L,Ichchou L,Abourazzak FZ,Abouqal R,Hajjaj-Hassouni N

    更新日期:2009-11-01 00:00:00

  • Discriminating infectious meningitis versus neuropsychiatric involvement in patients with systemic lupus erythematosus: a single-center experience.

    abstract::The objective of this study is to identify the clinical differences between infectious meningitis and neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with SLE. Clinical manifestations, laboratory test results, and prognoses of 14 SLE patients complicated with various infectious meningitis, hospitaliz...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2726-8

    authors: Chen J,Feng X,Wang H,Hua B,Ding C,Liu B,Sun L

    更新日期:2015-02-01 00:00:00

  • Association of cigarette smoking with Chinese ankylosing spondylitis patients in Taiwan: a poor disease outcome in systemic inflammation, functional ability, and physical mobility.

    abstract::We investigated the association between smoking and the disease activity, functional ability, physical mobility, and systemic inflammation in Chinese ankylosing spondylitis (AS) patients. Seventy five male Chinese AS patients in Taiwan were enrolled in the cross-sectional study. These patients fulfilled the 1984 modif...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2165-y

    authors: Chen CH,Chen HA,Lu CL,Liao HT,Liu CH,Tsai CY,Chou CT

    更新日期:2013-05-01 00:00:00

  • Serum IL 4 and its gene polymorphism (rs79071878) in Egyptian children with familial Mediterranean fever.

    abstract::Familial Mediterranean fever (FMF) is an autoinflammatory disorder. It is caused by mutations in the MEFV gene encoding the pyrin protein, which regulates the innate inflammatory response. The aim of the current study was to investigate the relationship between serum Interleukin-4 (IL-4) and its gene polymorphism, nam...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4214-z

    authors: Marzouk H,Farag Y,El-Hanafi HM,Ibrahim E

    更新日期:2018-12-01 00:00:00