Abstract：
:Idiopathic Inflammatory myopathies (IIM) are rare disorders. The aim of our study was to determine the incidence of IIM in a well-defined Slovenian region. This retrospective study was conducted at the Department of Rheumatology, University Medical Centre Ljubljana, the only secondary/tertiary rheumatology center in a region with a population of 704,342 adults. We identified potential IIM cases by searching the electronic patient records for ICD-10 codes M33, M35.1, M35.8, M60, G72, G73, and J84. We included incipient IIM cases between January 2010 and December 2017, who were at the time of the diagnosis, residents of the inspected region. To avoid under-reporting due to miscoded cases, we obtained a list of the patients who had histological patterns consistent with IIM on muscle biopsy from the Institute of Pathology. The annual incidence rate for IIM was calculated. During the eight-year observation period, we identified 65 IIM cases (72.3% female, median (IQR) patient age 64.8 (54.8-73.2) years). The estimated annual incidence of IIM in the studied population was 11.5 (95% CI 9.0-14.6) per 106 adults, in females 16.2 (95% CI 12.1-21.4), and in males 6.6 (95% CI 4.0-10.2) per 106 adults. The incidence rate of IIM in Slovenia is consistent with data from the literature.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Ostrovršnik J,Hočevar A,Rotar Ž,Krošel M,Čučnik S,Jurčić V,Tomšič Mdoi
10.1007/s10067-018-4237-5subject
Has Abstractpub_date
2019-02-01 00:00:00pages
279-283issue
2eissn
0770-3198issn
1434-9949pii
10.1007/s10067-018-4237-5journal_volume
38pub_type
杂志文章abstract：OBJECTIVE:To determine incidence of increased levels of alanine transferase (ALT) >2× upper limit of normal (ULN) in patients receiving methotrexate (MTX), treated according to a dynamic strategy, and to identify predictors of ALT of >2× ULN. METHODS:Data of 508 recent-onset rheumatoid arthritis (RA) patients from the...
journal_title：Clinical rheumatology
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1007/s100670200128
更新日期：2002-11-01 00:00:00
