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Comparison of three classification criteria of rheumatoid arthritis in an inception early arthritis cohort.

Abstract：

:The aim of this study is to compare the three classification criteria for rheumatoid arthritis (RA) in a large cohort of early arthritis patients. Patients who had at least one clinically swollen joint with disease duration no more than 1 year and age more than 18 years were enrolled. The clinical and laboratory parameters were recorded. The patients were diagnosed by two experienced rheumatologists. Undiagnosed patients were followed up every 3 months until 1 year. The sensitivity, specificity, and predictive value were compared among the early RA (ERA) criteria, the 1987 ACR criteria, and the 2010 ACR/EULAR criteria in this inception cohort of early arthritis patients. A total of 417 patients with inflammatory arthritis were recruited. By the end of 1 year follow-up, there were 399 patients (95.7 %) with a definitive diagnosis and 18 (4.3 %) patients remained as undifferentiated arthritis. Among the patients with definitive diagnosis, 202 (50.6 %) patients were diagnosed with RA and 197 (49.4 %) with non-RA. The sensitivity of ERA criteria was equal to 2010 ACR/EULAR criteria (both were 72.3 %), but much higher than 1987 ACR criteria (72.3 vs. 39.1 %, P < 0.001); the specificity of ERA criteria was comparable to 2010 ACR/EULAR criteria (87.8 vs. 83.2 %) and slightly lower than 1987 ACR criteria (87.8 vs. 92.4 %, P < 0.001). Unlike the complicated scoring system of 2010 criteria, the ERA criteria were more feasible to use in practice with five criteria only. The ERA criteria have a high sensitivity and more clinically feasibility in daily practice for early RA diagnosis.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Ye H,Su Y,Li R,Zhao J,Liu X,Mei Y,Zhang Z,Guo J,Bi L,Liu X,Wang G,Liu J,Leng X,Gu F,Sun L,Zou Q,Fang Y,Jiang Q,Li Z

doi

10.1007/s10067-016-3281-2

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2397-401

issue

10

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-016-3281-2

journal_volume

35

pub_type

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