Accelerated hypertension and nephroangiosclerosis associated with antiphospholipid syndrome. Report of two cases and review of the literature.

Abstract:

:We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertension and nephroangiosclerosis might indeed be one of the complications associated with anticardiolipin antibodies. The mechanism responsible might be the interaction of anticardiolipin antibodies, platelets and endothelial cell leading to microthrombi formation and increased local mitogenic activity that attract and stimulate neighbouring smooth muscle cell and fibroblast proliferation.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Durand JM,Lefevre P,Kaplanski G,Casanova P,Soubeyrand J

doi

10.1007/BF02243009

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

635-40

issue

4

eissn

0770-3198

issn

1434-9949

journal_volume

13

pub_type

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