Abstract:
:We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertension and nephroangiosclerosis might indeed be one of the complications associated with anticardiolipin antibodies. The mechanism responsible might be the interaction of anticardiolipin antibodies, platelets and endothelial cell leading to microthrombi formation and increased local mitogenic activity that attract and stimulate neighbouring smooth muscle cell and fibroblast proliferation.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Durand JM,Lefevre P,Kaplanski G,Casanova P,Soubeyrand Jdoi
10.1007/BF02243009subject
Has Abstractpub_date
1994-12-01 00:00:00pages
635-40issue
4eissn
0770-3198issn
1434-9949journal_volume
13pub_type
杂志文章,评审abstract::Shoulder pain may occur as a secondary symptom to a wide range of conditions, including rotator cuff disorders, glenohumeral osteoarthritis, or adhesive capsulitis. One common factor linking these diseases is inflammation. Understanding the role of inflammation in shoulder disorders can help physicians to manage and t...
journal_title:Clinical rheumatology
pub_type: 杂志文章,收录出版,评审
doi:10.1007/s10067-009-1109-z
更新日期:2009-05-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF-alpha) plays an important role in the pathogenesis of chronic inflammatory diseases, i.e., rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD), and ulcerative colitis (UC). Anti-TNF-alpha strategies are successfully used in their treatment. However, their effec...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2091-4
更新日期:2013-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3282-1
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:To explore the 18F-fluoro-dexoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging characteristics of adult-onset Still's disease (AOSD) and its significance in differential diagnosis from other connective tissue diseases (CTDs). METHODS:FDG PET/CT images of 54 patients with AOSD...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05041-3
更新日期:2020-09-01 00:00:00
abstract::We aimed to investigate the possible effects of thioredoxin 1 (Trx1) on the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and elucidate the possible mechanisms involved. We investigated the distribution and expression of Trx1 in synovial tissues from RA and osteoarthritis (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3832-1
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to identify and evaluate laboratory parameters associated with normal bone mineral density (BMD) and to test if -308 tumour necrosis factor (TNF) alpha gene promoter polymorphisms could influence BMD. We performed a comparative cross-sectional study of four main groups: young healthy individu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0706-y
更新日期:2008-03-01 00:00:00
abstract::Charcot joint or neuropathic arthropathy is described in certain neurological conditions. We report the case of a man who presented with a swollen ankle 10 days after a long walk, which rapidly progressed to a Charcot joint. A neurological examination revealed areflexia and insensitivity to temperature and pain. Elect...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050036
更新日期:2000-01-01 00:00:00
abstract::To compare the diagnostic powers of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) in a population selected for its high statistical relevance, over a 6-month period, an informed consent to test for anti-CCP was obtained from 1,025 consecutive patients for whom RF was ordered at a University labora...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0601-6
更新日期:2007-11-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:Primary Sjögren syndrome (pSS) is usually encountered between the fourth and sixth decades. It is known that the age of onset in autoimmune diseases may affect the clinical features. In this study, we aimed to investigate the clinical and laboratory characteristics of early onset pSS patients. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05017-3
更新日期:2020-09-01 00:00:00
abstract::In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resol...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04462-z
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Patients with axial spondyloarthritis (SpA) are subjected to elevated cardiovascular risks, but assessment of early myocardial damage and clinical risk stratification remained obscure. The aim of this study was to evaluate the prognostic value of speckle-tracking strain analysis and serum high-sensitivity tro...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05112-5
更新日期:2020-11-01 00:00:00
abstract::The current treatment for antiphospholipid syndrome (APS) with thrombotic manifestation is long-term anticoagulation. Vitamin K antagonists (VKA) are usually the agents of choice. However, VKA limitations, such as unpredictable anticoagulation effects due to interaction with diet and other drugs, require regular monit...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3030-y
更新日期:2016-03-01 00:00:00
abstract::In the original version of this article the first name of the co-author was incorrectly spelled as "Khaled A. Alnaqbi". The correct spelling should have been "Khalid A. Alnaqbi". This is now presented correctly in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4282-0
更新日期:2018-11-01 00:00:00
abstract::We encountered only three patients of carpal tunnel syndrome (CTS) due to tophaceous gout during 25 years of practice in a 'hand clinic' situated in a large metropolis in West India. In two patients, the CTS was bilateral, a rare occurrence in gout. There was an unwarranted delay (up to 9 years) in the diagnosis of bo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0672-4
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to identify the clinical characteristics of systemic lupus erythematosus-primary biliary cholangitis (SLE-PBC) patients and to compare the manifestations and prognosis with systemic lupus erythematosus (SLE) patients. METHODS:Twenty-one inpatients with concomitant SLE and primary biliary cho...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05457-x
更新日期:2020-10-16 00:00:00
abstract::Musculoskeletal disorders represent a large and growing clinical challenge to primary care clinicians. Unfortunately, there appears to be a gap in current training and continuing education to meet this challenge. We used script concordance within a continuing medical education program entitled "Joint Adventures" to as...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0446-4
更新日期:2007-07-01 00:00:00
abstract::The aims of this study were to characterize a minimally invasive technique of minor salivary gland biopsy of the lower lip and to present a large patient material undergoing this procedure because of a suspicion of Sjögren's syndrome (SS), as well as to assess the procedure's short-term and long-term value as a diagno...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0457-1
更新日期:2007-07-01 00:00:00
abstract::Central nervous involvement (CNS) is uncommon manifestation of Wegener's granulomatosis (WG). We are describing a patient with refractory WG with CNS involvement which responded to rituximab. This lady presented with nodular scleritis. Three months later, she developed headache, vision loss with complete opthalmoplegi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1291-z
更新日期:2010-01-01 00:00:00
abstract::The aim of this study was to investigate the involvement of autonomic nervous system (ANS) function by using power spectral analysis of heart rate variability (HRV) method in patients with ankylosing spondylitis (AS). The study included 94 AS patients all fulfilling the New York criteria for AS, and 49 healthy volunte...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/pl00011198
更新日期:2001-01-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-α G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial fluid (SF) of patients with r...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3699-1
更新日期:2017-07-01 00:00:00
abstract::We report two cases of a full-thickness rotator cuff tear followed by acromioclavicular cyst formation in patients with longstanding erosive polyarticular rheumatoid arthritis. One of the consequences of a rotator cuff tear is articular instability with upward migration of the humeral head. The ensuing chronic frictio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01452269
更新日期:1998-01-01 00:00:00
abstract::Chronic hepatitis C virus (HCV) viremia has been known to provoke a plethora of autoimmune syndromes referred to as extrahepatic manifestations of chronic HCV infection. Aim of the current study was to assess the prevalence of rheumatologic manifestations among Egyptians with hepatitis C infection and its' association...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1463-x
更新日期:2010-12-01 00:00:00
abstract::Hydroxyapatite (HA) crystal deposition disease is a common cause of acute inflammatory articular or periarticular pain. Here we report a patient with an acute hip arthritis due to HA crystal deposition of the round ligament. Therefore, HA crystal deposition in periarticular tendons and ligaments of the hip should be a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1089-z
更新日期:2009-04-01 00:00:00
abstract::Takayasu's arteritis (TA) is a rare vasculitis that affects the aorta and its primary branches. Heterogeneous clinical manifestations have been described in different geographical areas. We aimed to evaluate demographic, clinical, and angiographic features and the outcome in 16 TA patients who were followed in a singl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-1009-7
更新日期:2009-02-01 00:00:00
abstract::This study aims to explore the effectiveness of low dose of etanercept (ETN) in patients with ankylosing spondylitis (AS) who achieve a good control of their disease in daily clinical practice. This is a case series of AS patients treated with ETN. According to the judgment of the treating rheumatologist and patient's...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1722-5
更新日期:2011-07-01 00:00:00
abstract::Because the pathophysiology of knee osteoarthritis is poorly understood, optimal evidence-based clinical management is uncertain. Sibling comparison studies can help inform a clinical model to guide preventive care. We compared the 8-year clinical outcomes in 2 sisters with a family history of osteoarthritis, normal B...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05181-6
更新日期:2020-10-01 00:00:00
abstract::Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02114402
更新日期:1990-09-01 00:00:00
abstract::A few studies have reported the safety profile of interleukin (IL)-1 blockers from real life. The aim of this study is to describe anakinra (ANA) and canakinumab (CAN) safety profile in children and adults, based on data from a real-life setting. Demographic, clinical, and therapeutic data from patients treated with A...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-018-4119-x
更新日期:2018-08-01 00:00:00
abstract::In patients with rheumatoid arthritis who had symptomatic knee joints at the start of anti-tumor necrosis factor (TNF) therapy, the relationship between local symptoms and knee joint destruction at 94 weeks was retrospectively investigated. Among the patients with rheumatoid arthritis and received anti-TNF therapy, th...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2181-y
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:(1) Development and validation of a composite ultrasound score (cUSS) for the diagnosis of carpal tunnel syndrome (CTS). (2) To predict treatment response after local corticosteroid injection. METHODS:Wrists of CTS patients and controls were evaluated with high-resolution ultrasound and cross-sectional area...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05228-8
更新日期:2020-07-21 00:00:00