Abstract:
:Intercellular adhesion molecule-1 (ICAM-1) is a membrane bound molecule that plays an important role in the pathogenic inflammatory responses observed in vasculitis. The aim of this study was to determine whether levels of soluble ICAM-1 sICAM-1) shedding into the circulation reflect the vascular injury found in nailfold capillaroscopy as well as systemic vasculitis in RA patients. We determined serum levels of sICAM-1 and soluble interleukin-2 receptor (sIL-2R) by an enzyme-linked immunosorbent assay in 79 RA patients. Serum levels of sICAM-1 were significantly increased in RA patients compared to 30 healthy controls. RA patients with clinical signs of systemic vasculitis showed significantly higher levels of sICAM-1 than those without vascular involvement. Although no significant correlation between sICAM-1 levels and the capillaroscopy findings were found, 75% of the patients with severe vascular changes in capillaroscopy exceeded normal sICAM-1 cut off value. Serum sICAM-1 concentrations correlated significantly with the erythrocyte sedimentation rate and serum sIL-2R, but not with the duration of RA, radiological stages, Ritchie index, age or type of treatment. These findings suggest that increased levels of sICAM-1 in serum of RA patients reflect systemic vascular involvement rather than a local vascular injury.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Kuryliszyn-Moskal A,Bernacka K,Klimiuk PAdoi
10.1007/BF02230359subject
Has Abstractpub_date
1996-07-01 00:00:00pages
367-73issue
4eissn
0770-3198issn
1434-9949journal_volume
15pub_type
杂志文章abstract::Two cases of late hypophosphatemic osteomalacia are described: a male aged 30 who had the disease since he was 22 and a woman of 23 who had the disease since she was 14. Both presented with myopathy and bone pain, and showed hypophosphatemia, hyperglycinuria, reduced tubular phosphate reabsorption (TPR), increased hyd...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031617
更新日期:1985-09-01 00:00:00
abstract::Hundreds of randomized controlled trials (RCTs) on tripterygium glycosides tablet (TGT) in the treatment of ankylosing spondylitis (AS) have been published, but the therapeutic effects have never been systematically reviewed yet. The aim of this meta-analysis was to evaluate the efficacy of TGT on AS based on RCTs. Pu...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10067-015-3043-6
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abstract::Total body bone mineral (TBBM) measured by dual photon absorptiometry and local bone mineral (BMC) measured by single photon absorptiometry were determined in 55 patients with definite or classical rheumatoid arthritis. All of them had been on a steady dose of anti-inflammatory drugs for at least 12 months, and furthe...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02041401
更新日期:1983-09-01 00:00:00
abstract::Subcutaneous rheumatoid nodules occur commonly in advanced cases of rheumatoid arthritis and are the most common extra-articular lesion of this disease. We present a case of a very unusual giant rheumatoid nodule that developed on the lateral side of a knee. The case was devoid of systemic symptoms of arthritis and th...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0926-3
更新日期:2004-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05181-6
更新日期:2020-10-01 00:00:00
abstract::We report a young male with recent onset of rheumatoid arthritis (RA) in whom the remarkable severity of the disease led to additional investigations. The only significant finding was mediastinal lymphadenopathy, without lung involvement. Biopsy of the mediastinal lymph node revealed pathological findings typical of s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-002-0639-4
更新日期:2003-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
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更新日期:2006-02-01 00:00:00
abstract::The American College of Rheumatology (ACR) classification criteria for lupus and Systemic Lupus International Collaborating Clinics (SLICC) criteria are designed to classify disease. However, they have become widely used as diagnostic criteria in clinical situations. Patients may be labelled as systemic lupus erythema...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-3999-0
更新日期:2018-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0784-4
更新日期:2003-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0264-8
更新日期:2007-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3698-2
更新日期:2018-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4030-5
更新日期:2018-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0215-4
更新日期:2007-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-017-3541-9
更新日期:2017-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0813-9
更新日期:2008-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0435-7
更新日期:2007-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1900-5
更新日期:2012-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-2883-4
更新日期:2015-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1846-7
更新日期:2011-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4157-4
更新日期:2018-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF02229644
更新日期:1996-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04607-0
更新日期:2019-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4014-5
更新日期:2018-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0937-0
更新日期:2004-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-015-2904-3
更新日期:2015-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1599-8
更新日期:2011-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05020-8
更新日期:2020-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050052
更新日期:1999-01-01 00:00:00