Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study.


:Reduced physical function and health-related quality of life are common in rheumatoid arthritis (RA), and further studies are needed that examine novel determinates of reduced physical function in RA. This study examines whether frailty, a state of increased vulnerability to stressors, is associated with differences in self-reported physical function among adults with RA. Adults from a longitudinal RA cohort (n = 124) participated in the study. Using an established definition of frailty, individuals with three or more of the following physical deficits were classified as frail: (1) body mass index ≤18.5, (2) low grip strength (adjusted for sex and body mass index (BMI), measured by handheld dynamometer), (3) severe fatigue (measured by the Multidimensional Assessment of Fatigue), (4) slow 4-m walking speed (adjusted for sex and height), and (5) low physical activity (measured by the International Physical Activity Questionnaire). Individuals with one or two deficits were classified as "pre-frail" and those with no deficits as "robust." Self-reported physical function was assessed by the Health Assessment Questionnaire (HAQ) and the Valued Life Activities Difficulty scale. Regression analyses modeled associations of frailty category with HAQ and Valued Life Activities (VLA) Difficulty scores with and without controlling for age, sex, disease duration, C-reactive protein, use of oral steroids, and pain. Among adults with RA, being frail compared to being robust was associated with a 0.44 worse VLA score (p < 0.01) when the effects of covariates are held constant. Being frail, compared to being robust, is associated with clinically meaningful differences in self-reported physical function among adults with RA.


Clin Rheumatol


Clinical rheumatology


Andrews JS,Trupin L,Yelin EH,Hough CL,Covinsky KE,Katz PP




Has Abstract


2017-05-01 00:00:00














  • Predictive factors of rapidly progressive-interstitial lung disease in patients with clinically amyopathic dermatomyositis.

    abstract::Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, showing a high incidence of lung involvements. The aim of this study is to identify risk factors, other than melanoma differentiation-associated protein (MDA)-5, for developing rapidly progressive-interstitial lung disease (RP-ILD) in ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Xu Y,Yang CS,Li YJ,Liu XD,Wang JN,Zhao Q,Xiao WG,Yang PT

    更新日期:2016-01-01 00:00:00

  • Changes in immune cell frequencies after cyclophosphamide or mycophenolate mofetil treatments in patients with systemic lupus erythematosus.

    abstract::This study was designed to explore the profile of immune cell subsets, including T, B, natural killer (NK), and NKT cells, in systemic lupus erythematosus (SLE) patients, and to determine their relationships with the clinical index and the effects of cyclophosphamide (CYC) and mycophenolate mofetil (MMF) treatment. SL...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Zhao L,Jiang Z,Jiang Y,Ma N,Wang K,Zhang Y

    更新日期:2012-06-01 00:00:00

  • Protrusio acetabuli in juvenile rheumatoid arthritis.

    abstract::Acetabular protrusion (PA) as measured by a line crossing method was studied in 73 patients with juvenile rheumatoid arthritis (JRA) and its frequency found to be 12% (9/73), presenting bilaterally in 5 cases and unilaterally in 4. All patients had some other forms of radiological damage and the presence of PA was pre...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Gusis SE,Maldonado Cocco JA,Rivero EM,Babini JC,Gagliardi SA

    更新日期:1993-03-01 00:00:00

  • A patient with ankylosing spondylitis who presented with chronic necrotising aspergillosis: report on one case and review of the literature.

    abstract::Upper lobe fibrobullous disease is a well-known finding in advanced stages of ankylosing spondylitis (AS). In this report, we present a 57-year-old male patient who was diagnosed with a right apical cavitary lesion after coming to us with the complaint of haemoptysis. The patient underwent upper lobe segmentectomy and...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Pamuk ON,Harmandar O,Tosun B,Yörük Y,Cakir N

    更新日期:2005-08-01 00:00:00

  • Discussing sexual concerns with chronic low back pain patients: barriers and patients' expectations.

    abstract::This study aims to explore patient's concerns when discussing sexual problems caused by chronic low back pain with their healthcare provider. It also aims to identify factors influencing and limiting such communication. A cross-sectional analysis of 100 consenting chronic low back pain sexually active patients was car...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Bahouq H,Allali F,Rkain H,Hajjaj-Hassouni N

    更新日期:2013-10-01 00:00:00

  • Subcutaneous sarcoidosis: report of two cases and review of the literature.

    abstract::Sarcoidosis is a multisystemic disease with cutaneous lesions present in about one fourth of patients. Cutaneous lesions may be specific or nonspecific based on the presence or the absence of sarcoidal granulomas. Subcutaneos sarcoidosis is the less frequent of the specific cutaneous lesions of sarcoidosis. We report ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Dalle Vedove C,Colato C,Girolomoni G

    更新日期:2011-08-01 00:00:00

  • Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosus.

    abstract::The aim of this study was to determine the serum interleukin-18 (IL-18) levels in patients with systemic lupus erythematosus (SLE) and to assess their relationship with disease activity. Thirty-five patients with SLE and 35 age- and sex-matched controls were enrolled in this study. Paired serum samples were collected ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Park MC,Park YB,Lee SK

    更新日期:2004-06-01 00:00:00

  • Serum transferrin receptor levels in patients with rheumatoid arthritis are correlated with indicators for anaemia.

    abstract::To measure serum soluble transferrin receptor (s-TfR) levels in patients with rheumatoid arthritis (RA), sera were obtained from 50 Japanese RA patients and 20 healthy subjects. Both s-TfR and serum erythropoietin (EPO) levels were measured by enzyme-linked immunosorbent assay (ELISA). Routine laboratory tests were al...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章


    authors: Chijiwa T,Nishiya K,Hashimoto K

    更新日期:2001-01-01 00:00:00

  • Phrasing of the patient global assessment in the rheumatoid arthritis ACR/EULAR remission criteria: an analysis of 967 patients from two databases of early and established rheumatoid arthritis patients.

    abstract::The ACR/EULAR Boolean remission criteria for rheumatoid arthritis (RA) include a strict cutoff for patient global assessment (PGA, value ≤ 1/10). Near-remission corresponds to remission for joint counts and C-reactive protein but with PGA > 1. The objective was to explore whether the contribution of PGA to remission a...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Gossec L,Kirwan JR,de Wit M,Balanescu A,Gaujoux-Viala C,Guillemin F,Rat AC,Saraux A,Fautrel B,Kvien TK,Dougados M,RAID investigators.

    更新日期:2018-06-01 00:00:00

  • Emerging lupus-like manifestations in acute parvovirus B19 infection.

    abstract::We encountered an adult patient with acute parvovirus B19 infection who presented with transient lupus-like symptoms (i.e., polyarthritis, fever, myalgia, pancytopenia, hypocomplementemia, and nephritis). Our case is characterized by the demonstration of acute nephritis as a complication of this infection, making it d...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Sugimoto T,Tsuda A,Uzu T,Kashiwagi A

    更新日期:2008-01-01 00:00:00

  • Imaging of sacroiliitis.

    abstract::Inflammation of one or both sacroiliac joints is a characteristic feature of patients with spondyloarthropathies (SpA). Sacroiliitis often leads to inflammatory back pain (IBP). IBP and asymmetric peripheral arthritis of the lower limbs are the main clinical symptoms and criteria for classification and diagnosis of Sp...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Braun J,Sieper J,Bollow M

    更新日期:2000-01-01 00:00:00

  • Coexistence of ankylosing spondylitis and undifferentiated connective tissue disease.

    abstract::We report the case of a 45-year-old Caucasian woman suffering from ankylosing spondylitis and undifferentiated connective tissue disease in whom the prevailing clinical features were retinal vasculitis and inflammatory low back pain. HLA typing revealed the concomitant presence of B27 and DR2 antigens. We hypothesise ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Galluzzo E,Taglione E,Bartolomei MP,Pasero G,Riente L

    更新日期:1998-01-01 00:00:00

  • The use of bisphosphonate in the treatment of avascular necrosis: a systematic review.

    abstract::Up to now, there is no uniformly accepted treatment for avascular necrosis (AN) that alleviates pain and retards its progression. The aim of clinical and surgical treatments is usually only to improve blood support in the avascular area. The objective of the present study was to make a systematic review of the use of ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Cardozo JB,Andrade DM,Santiago MB

    更新日期:2008-06-01 00:00:00

  • Sjögren's syndrome in patients with ankylosing spondylitis.

    abstract::There are few reports about the coexistence of Sjögren's syndrome (SS) and ankylosing spondylitis (AS). To evaluate the frequency of SS in patients with AS. We studied 70 patients with AS presenting to the university outpatient clinic between January 2002 and November 2003. All the patients were asked about sicca symp...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Kobak S,Kobak AC,Kabasakal Y,Doganavsargil E

    更新日期:2007-02-01 00:00:00

  • Rheumatoid nodulosis: a puzzling variant of rheumatoid arthritis.

    abstract::Four patients with rheumatoid nodulosis are here described, together with a review of cases reported to date in the literature. This particular variant of rheumatoid arthritis (RA) is characterized by the presence of subcutaneous rheumatoid nodules, scanty or absent systemic manifestations and a clinically benign cour...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Goñi MA,Scheines EJ,Paira SO,Barceló HA,Maldonado Cocco JA

    更新日期:1992-09-01 00:00:00

  • Evaluating the diagnostic and prognostic value of lone anti-Sm for autoimmune diseases using Euroimmun line immunoassays.

    abstract::To investigate the value of lone anti-Smith antibody (anti-Sm) using Euroimmun line immunoassay (LIA) in a Chinese population. One thousand two hundred eight of 39,766 patients who were analyzed for anti-Sm had positive anti-Sm, and were divided into true group (having both positive Sm and nRNP/Sm bands) and lone grou...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Meng Y,Deng S,Huang Z,Hu J,Zhang J,Xu D,Qin S,Tan C,Wu Y

    更新日期:2018-11-01 00:00:00

  • Cardiovascular risk stratification and appropriate use of statins in patients with systemic lupus erythematosus according to different strategies.

    abstract:INTRODUCTION/OBJECTIVES:Cardiovascular risk management of patients with systemic lupus erythematosus (SLE) is medically relevant. The objectives were to estimate the cardiovascular risk by different strategies in patients with SLE, analyzing which proportion of patients would be candidates to receive statin therapy, an...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Masson W,Rossi E,Mora-Crespo LM,Cornejo-Peña G,Pessio C,Gago M,Alvarado RN,Scolnik M

    更新日期:2020-02-01 00:00:00

  • Can procalcitonin be used to distinguish between disease flare and infection in patients with systemic lupus erythematosus: a systematic literature review.

    abstract::Distinction between infection and febrile disease flare in patients with systemic lupus erythematosus (SLE) is fundamental but often difficult to make, because clinical presentation can be similar. A systematic review of all articles indexed in PubMed through October 2013 was performed, in order to examine the potenti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Serio I,Arnaud L,Mathian A,Hausfater P,Amoura Z

    更新日期:2014-09-01 00:00:00

  • Impact of TNF-α inhibitor on lipid profile and atherogenic index of plasma in axial spondyloarthritis: 2-year follow-up data from the Catholic Axial Spondyloarthritis COhort (CASCO).

    abstract::To evaluate the influence of TNF-α inhibitor on lipid profile and atherogenic index of plasma (AIP) in axial spondyloarthritis (axSpA) patients with long-term use of stable dose TNF-α inhibitor. AxSpA patients were enrolled in the Catholic Axial Spondyloarthritis COhort (CASCO). We collected their data annually and an...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Min HK,Lee J,Ju JH,Park SH,Kwok SK

    更新日期:2020-02-01 00:00:00

  • Central nervous system involvement in patients with antineutrophil cytoplasmic antibody-associated vasculitis: a study of 29 cases in a single Chinese center.

    abstract:BACKGROUND:In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. METHODS:A total of 497 AAV patients were retrosp...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Ma TT,Li ZY,Geng YS,Chen M,Zhao MH

    更新日期:2020-07-01 00:00:00

  • Mycophenolate mofetil in Takayasu's arteritis.

    abstract::Mycophenolate mofetil (MMf) has recently been reported as a useful alternative immunosuppressive drug in autoimmune diseases. There is paucity of literature on its use in Takayasu's arteritis (TA). The aim of this study was to assess the safety and efficacy of MMf in Asian Indian patients with Takayasu's arteritis. Re...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Goel R,Danda D,Mathew J,Edwin N

    更新日期:2010-03-01 00:00:00

  • Case report: successful treatment of membranous lupus nephritis with belimumab in an African female immigrant.

    abstract::We describe the case of a 26-year-old African female who was treated successfully with belimumab in a case of severe membranous lupus nephritis and retinal vasculitis, resistant to first line therapy. She presented initially with chronic dacryoadenitis and screening showed nephrotic-range proteinuria. Biopsy of the ki...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: De Scheerder MA,Boey O,Mahieu E,Vanuytsel J,Bogaert AM

    更新日期:2016-06-01 00:00:00

  • Association of juvenile idiopathic arthritis and morphea: a case series.

    abstract::The association of different autoimmune diseases in the same subject is not uncommon, also in the pediatric age. The coexistence of morphea and juvenile idiopathic arthritis (JIA) is however exceptional. We report four such cases. Unlike the few other reported cases, in 3/4 of our patients, morphea appeared well after...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Giani T,Madera A,Cimaz R

    更新日期:2020-04-01 00:00:00

  • Comparison of signal detection of tumour necrosis factor-α inhibitors using the Korea Adverse Events Reporting System Database, 2005-2016.

    abstract:OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Ha D,Lee SE,Song I,Lim SJ,Shin JY

    更新日期:2020-02-01 00:00:00

  • A 'made in one piece' skeleton in a 22-year-old man suffering from sickle cell anaemia.

    abstract::A 22-year-old African male with known sickle cell anaemia was referred by a Congolese medical centre with a request to improve his poor physical condition. He was unable to walk, stand or sit because his large joints and his spine were either ankylosed or very rigid. Radiographs showed joint fusion from the third to t...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Dumarey N,Martin P,Jayankura M,Putz P,Verhas M,Peretz A

    更新日期:2000-01-01 00:00:00

  • The effect of anti-TNF agent on oxidation status in patients with ankylosing spondylitis.

    abstract::The aim of this study was to comparatively evaluate oxidative status of ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor (TNF) or non-steroid anti-inflammatory drugs (NSAID). Forty-seven patients with AS and 27 healthy controls were enrolled. Of these, 23 were on anti-TNF (group 1) and 24 on N...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Karkucak M,Capkin E,Alver A,Akyuz A,Kiris A,Ak E,Topbas M,Tosun M

    更新日期:2010-03-01 00:00:00

  • Proteoglycan metabolism in isolated chondrocytes from human cartilage. Influence of niflumic acid.

    abstract::The effect of niflumic acid on hyaluronic acid and proteoglycan metabolism of human cartilage cells was investigated in vitro. Cartilage cells were obtained from five different donors. Niflumic acid levels used in the test systems ranged from 0 to 22 microgramsr/ml and were comparable to serum concentrations in humans...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Verbruggen G,Veys EM,Malfait AM,Schatteman L,Wieme N,Nimmegeers J,Gerin MG,Broddelez C

    更新日期:1990-03-01 00:00:00

  • Polymyositis associated with primary biliary cirrhosis.

    abstract::The coexistence of polymyositis (PM) and primary biliary cirrhosis (PBC) is rare; only nine cases have been described in English literature. We report a case of a 46-year-old woman presenting with these two autoimmune diseases. The diagnosis of PM was based on the symmetrical, proximal limb muscle weakness, elevated m...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Boki KA,Dourakis SP

    更新日期:1995-05-01 00:00:00

  • Predicting outcomes in rheumatoid arthritis.

    abstract::Biologic therapies have brought improved efficacy in the field of rheumatoid arthritis (RA), but their use in clinical practice may be limited by concerns over cost. Predictive models are, therefore, needed to identify those people with RA with the worst potential outcomes, who will benefit most from the use of these ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审


    authors: Conaghan PG

    更新日期:2011-03-01 00:00:00

  • Systemic sclerosis is associated with knee arthroplasty outcomes: a National US study.

    abstract:OBJECTIVE:To assess whether systemic sclerosis (SSc) is associated with total knee arthroplasty (TKA) outcomes. METHODS:We used the 1998-2014 US National Inpatient Sample. We conducted multivariable-adjusted logistic regression analyses to examine the association of a diagnosis of SSc with post-TKA in-hospital complic...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章


    authors: Singh JA,Cleveland JD

    更新日期:2020-01-01 00:00:00