Impact of treatment with TNF antagonists on total cholesterol in patients with ankylosing spondylitis and psoriatic arthritis.

Abstract:

:The objective of the study was to analyze the impact of TNF antagonists (TNFa) on the total cholesterol and triglycerides on ankylosing spondylitis (AS) and psoriatic arthritis (PsA). In this single-centre observational study of AS and PsA patients, differences in triglyceride and total cholesterol levels and frequency of hypertriglyceridemia and hypercholesterolemia at 3 and 6 months were analysed in patients treated and not treated with TNFa. General estimation equations and linear regression analysis were used to investigate associations between disease activity and lipid levels and to identify predictors of change. One hundred fifty-seven patients treated, and 157 not treated with TNFa, were included in the study. A transient increase in cholesterol level from baseline to 3 months in TNFa-treated patients was the only statistically significant effect (P < 0.001). Persistent percentages of hypertriglyceridemia and hypercholesterolemia from baseline were significantly higher in not treated than in TNFa-treated patients (P = 0.009 and P = 0.001, respectively). Inverse associations between changes in cholesterol level and Bath Ankylosing Spondylitis Disease Activity Index (P = 0.011) and CRP (P < 0.001), but not Disease Activity Score in 28 Joints (P = 0.095) were found in the whole group. In AS and PsA patients treated with TNFa, mild and transient changes in cholesterol but not in triglyceride levels were associated with changes in disease activity.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Maneiro JR,Souto A,Gomez-Reino JJ

doi

10.1007/s10067-017-3537-5

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

1167-1172

issue

5

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-017-3537-5

journal_volume

36

pub_type

杂志文章
  • Evaluation of tool-like receptor-2 and 4 and interleukin-6 gene expressions in Turkish rheumatoid arthritis patients.

    abstract::Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3282-1

    authors: Eser B,Sahin N

    更新日期:2016-11-01 00:00:00

  • Clinical features associated with pregnancy outcomes in women with positive antiphospholipid antibodies and previous adverse pregnancy outcomes: a real-world prospective study.

    abstract:OBJECTIVE:This study aims to analyze factors related to pregnancy outcomes in women with positive antiphospholipid antibodies and previous adverse pregnancy outcomes (APOs) prospectively. METHODS:Patients' characteristics were described. Factors associated with obstetric complications were analyzed using logistic regr...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05203-3

    authors: Li X,Deng X,Duan H,Zeng L,Zhou J,Liu C,Guo X,Liu X

    更新日期:2021-01-01 00:00:00

  • Damage accrual, cumulative glucocorticoid dose and depression predict anxiety in patients with systemic lupus erythematosus.

    abstract::The burden of anxiety in patients with systemic lupus erythematosus (SLE) compared to those with other inflammatory rheumatological conditions is unclear. We aimed to compare the frequency and level of anxiety between patients with SLE, rheumatoid arthritis (RA), and gout and healthy individuals and explore independen...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-010-1651-8

    authors: Mak A,Tang CS,Chan MF,Cheak AA,Ho RC

    更新日期:2011-06-01 00:00:00

  • Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.

    abstract::We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoprol...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02231567

    authors: Taillan B,Garnier G,Castanet J,Ferrari E,Pesce A,Dujardin P

    更新日期:1993-03-01 00:00:00

  • Ochronotic spondyloarthropathy: spinal involvement resembling ankylosing spondylitis.

    abstract::Ochronotic spondyloarthropathy is a rare metabolic disease with the musculoskeletal manifestations of alkaptonuria. Ochronotic arthropathy patients may have spinal abnormalities similar to ankylosing spondylitis (AS). The proof of sacroiliac involvement or bamboo spine appearance is not sufficient either for diagnosis...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0038-8

    authors: Balaban B,Taskaynatan M,Yasar E,Tan K,Kalyon T

    更新日期:2006-07-01 00:00:00

  • Peripheral bone density in patients with rheumatoid arthritis.

    abstract::Bone loss in patients with rheumatoid arthritis (RA) varies at different skeletal sites. The aim of the study was to evaluate whether bone mineral density (BMD) of the forearm is significantly different in patients with RA and controls and may correlate to BMD or other parameters of inflammation or bone resorption. We...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1211-2

    authors: Franck H,Gottwalt J

    更新日期:2009-10-01 00:00:00

  • Clinical characteristics and treatment outcomes of patients with relapsing polychondritis with airway involvement.

    abstract::We investigated the clinical characteristics, management modalities, and outcomes in patients with relapsing polychondritis (RP) with airway involvement. The medical records of RP patients with airway involvement seen at Samsung Medical Center from August 2004 to December 2011 were collected. The clinical manifestatio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2279-2

    authors: Hong G,Kim H

    更新日期:2013-09-01 00:00:00

  • Clinical course and outcomes of COVID-19 in rheumatic disease patients: a case cohort study with a diverse population.

    abstract:OBJECTIVE:To determine clinical course and outcomes in rheumatic disease patients with coronavirus disease 2019 (COVID-19) and compare results to uninfected patients. METHODS:We conducted a case cohort study of autoimmune disease patients with COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR)...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-021-05578-x

    authors: Arleo T,Tong D,Shabto J,O'Keefe G,Khosroshahi A

    更新日期:2021-01-09 00:00:00

  • Combination therapy with cyclosporine A and anti-TNF-alpha agents in the treatment of rheumatoid arthritis and concomitant hepatitis C virus infection.

    abstract::We describe two cases of rheumatoid arthritis (RA) patients and concomitant hepatitis C virus infection (HCV), treated with cyclosporine A (CsA) and anti-TNF-alpha agents. SGOT/SGPT and HCV-RNA serum levels remained unchanged longer than 1 year of treatment. No side effects were registered. We suggest that combination...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0412-1

    authors: Bellisai F,Giannitti C,Donvito A,Galeazzi M

    更新日期:2007-07-01 00:00:00

  • Acute and long-term effect of infliximab on humoral and echocardiographic parameters in patients with chronic inflammatory diseases.

    abstract::Tumor necrosis factor alpha (TNF-alpha) plays an important role in the pathogenesis of chronic inflammatory diseases, i.e., rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD), and ulcerative colitis (UC). Anti-TNF-alpha strategies are successfully used in their treatment. However, their effec...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2091-4

    authors: Tomáš L,Lazúrová I,Pundová L,Oetterová M,Zakuciová M,Petrášová D,Studenčan M

    更新日期:2013-01-01 00:00:00

  • Clinical features, risk factors, and outcomes of septic arthritis in patients on maintenance hemodialysis.

    abstract::The aim of this study was to investigate the clinical features, risk factors, and outcomes of septic arthritis in patients on maintenance hemodialysis (HD). We systematically reviewed medical records of 16 HD patients with septic arthritis admitted to our hospital from April 2008 to April 2018. A total of 16 HD in pat...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05114-3

    authors: Zhang J,You X

    更新日期:2020-10-01 00:00:00

  • Individual choice of opioids and formulations: strategies to achieve the optimum for the patient.

    abstract::The role of opioid therapy in chronic musculoskeletal disease continues to be controversial. However, recent years have seen a gradual shift towards the use of opioid therapy in chronic non-malignant pain (CNMP) following recognition that at least a subpopulation of such patients appears to benefit from long-term opio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s100670200029

    authors: Simpson KH

    更新日期:2002-02-01 00:00:00

  • Gout: a disease involved with complicated immunoinflammatory responses: a narrative review.

    abstract::Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and subcutaneous sites. In recent years, with the continuous research on gout animal models and patient clinical investigations, the mechanism of i...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-020-05090-8

    authors: Wu M,Tian Y,Wang Q,Guo C

    更新日期:2020-10-01 00:00:00

  • Patient-reported involvement of the eighth cranial nerve in giant cell arteritis.

    abstract:INTRODUCTION:The frequency of eighth nerve lesions in patients with giant cell arteritis (GCA) has rarely been examined. However, sudden onset deafness has been recorded as a presenting feature of GCA on several occasions. This study sought to establish how common this and other symptoms of eighth nerve involvement are...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-019-04747-3

    authors: Saravanan V,Pugmire S,Smith M,Kelly C

    更新日期:2019-12-01 00:00:00

  • A 2-year observational study on treatment targets in psoriatic arthritis patients treated with TNF inhibitors.

    abstract::The aim of this study was to evaluate clinical remission and MDA in PsA patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Concomitant therapies as well as comorbidities were assessed. Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3769-4

    authors: Chimenti MS,Triggianese P,Conigliaro P,Tonelli M,Gigliucci G,Novelli L,Teoli M,Perricone R

    更新日期:2017-10-01 00:00:00

  • Giant cell arteritis with normal inflammatory markers: case report and review of the literature.

    abstract::Giant cell arteritis (GCA) is a granulomatous vasculitis involving large- and middle-sized arteries, with a predilection for cranial arteries. In this paper, we aim to describe a case of a biopsy- and ultrasound-proven GCA, presenting with anterior ischemic optic neuropathy (AION) and normal CRP and ESR at diagnosis a...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-020-05116-1

    authors: Martins P,Teixeira V,Teixeira FJ,Canastro M,Palha A,Fonseca JE,Ponte C

    更新日期:2020-10-01 00:00:00

  • Primary biliary cirrhosis (PBC)-CREST overlap syndrome with coexistence of Sjögren's syndrome and thyroid dysfunction.

    abstract::Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia (CREST) syndrome, a limited form of systemic sclerosis, is sometimes complicated by primary biliary cirrhosis (PBC). A 52- and 61-year-old Japanese woman with PBC-CREST overlap syndrome accompanied by Sjögren's syndrome, and Hashi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0178-x

    authors: Nakamura T,Higashi S,Tomoda K,Tsukano M,Sugi K

    更新日期:2007-04-01 00:00:00

  • Primary antiphospholipid syndrome associated with mesenteric inflammatory veno-occlusive disease.

    abstract::We describe a 24-year old Caucasian man with gangrene of small bowels and intestinal resection due to mesenteric inflammatory veno-occlusive disease (MIVOD) who later developed deep vein thrombosis in his left leg. He had no clinical evidence of an underlying symptomatic connective tissue disease or Behçet's disease. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02230344

    authors: Gül A,Inanç M,Ocal L,Koniçe M,Aral O,Lie JT

    更新日期:1996-03-01 00:00:00

  • Severe gastrointestinal involvement in systemic sclerosis.

    abstract::Gastrointestinal tract (GIT) is the most common organ system involved in systemic sclerosis (SSc). GIT involvement is mainly attributed to GIT dismobility and wide mouth diverticular. GIT involvement in SSc can be also severely debilitating and even life threatening. To our knowledge, the presence of gastrointestinal ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-006-0264-8

    authors: Plastiras SC,Tzivras M,Vlachoyiannopoulos PG

    更新日期:2007-06-01 00:00:00

  • Safety of weekly adalimumab in the treatment of juvenile idiopathic arthritis and pediatric chronic uveitis.

    abstract::Weekly adalimumab dosing is used to treat juvenile idiopathic arthritis (JIA), uveitis, and other pediatric rheumatic diseases, but the safety of such dosing has not previously been studied. A retrospective chart review was conducted to assess the safety of weekly adalimumab. Demographic and clinical data were collect...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3890-4

    authors: Correll CK,Bullock DR,Cafferty RM,Vehe RK

    更新日期:2018-02-01 00:00:00

  • Socio-economic gradients in the presence of musculoskeletal and other chronic diseases: results from a cross-sectional study in the Netherlands.

    abstract::Socio-economic gradients in occurrence of diseases have been reported for many chronic conditions. However, whether the magnitude of socio-economic gradients differs across diseases and the extent to which lifestyle mediates such relationships are not known. Cross-sectional data from The National Monitor on Musculoske...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4158-3

    authors: Putrik P,Ramiro S,Chorus AM,Keszei AP,Boonen A

    更新日期:2018-12-01 00:00:00

  • Screening for the presence of FMR1 premutation alleles in a Spanish population with fibromyalgia.

    abstract::Fragile X mental retardation 1 (FMR1) premutation carriers, who are at risk of having children with fragile X Syndrome, were initially considered as clinically unaffected. However, recent clinical and molecular studies have shifted this point of view. The incidence of premutation in the general population is substanti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-012-2052-y

    authors: Martorell L,Tondo M,Garcia-Fructuoso F,Naudo M,Alegre C,Gamez J,Genovés J,Poo P

    更新日期:2012-11-01 00:00:00

  • Comparison of three classification criteria of rheumatoid arthritis in an inception early arthritis cohort.

    abstract::The aim of this study is to compare the three classification criteria for rheumatoid arthritis (RA) in a large cohort of early arthritis patients. Patients who had at least one clinically swollen joint with disease duration no more than 1 year and age more than 18 years were enrolled. The clinical and laboratory param...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3281-2

    authors: Ye H,Su Y,Li R,Zhao J,Liu X,Mei Y,Zhang Z,Guo J,Bi L,Liu X,Wang G,Liu J,Leng X,Gu F,Sun L,Zou Q,Fang Y,Jiang Q,Li Z

    更新日期:2016-10-01 00:00:00

  • Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.

    abstract::In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis. A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery. The correlation between the haematolo...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02231787

    authors: Bolla G,Disdier P,Harle JR,Verrot D,Weiller PJ

    更新日期:1993-12-01 00:00:00

  • The risk of leukemia in patients with rheumatoid arthritis: a systematic review and meta-analysis.

    abstract:OBJECTIVES:The relationship between rheumatoid arthritis (RA) and the risk of leukemia was still controversial. This study aimed to assess the risk of leukemia in patients with rheumatoid arthritis by systematic review and meta-analysis. METHODS:Relevant studies were identified by searching PubMed, Embase, Cochrane Li...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05396-7

    authors: Luo X,He Y,Xu W,Liu M,Zhao Z,Peng L,He C,Chen J

    更新日期:2020-09-17 00:00:00

  • The associations of phase angle with the structural severity and quadriceps strength among patients with hip osteoarthritis: the SPSS-OK study.

    abstract:INTRODUCTION/OBJECTIVES:This study examined whether phase angle (PhA) is associated with hip osteoarthritis (HOA) severity and quadriceps strength in patients with HOA. METHOD:A series of 549 patients with HOA, obtained from the Screening for People Suffering Sarcopenia in the Orthopedic cohort of Kobe study, were ana...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-05419-3

    authors: Wada O,Yamada M,Kamitani T,Mizuno K,Kurita N

    更新日期:2020-09-29 00:00:00

  • Urine macrophage migration inhibitory factor in pediatric systemic lupus erythematosus.

    abstract::We reported a series of ten patients with lupus nephritis (five patients in the relapse phase and five in the remission phase) and measured the macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine with probable role in the pathogenesis of many inflammatory diseases, in their urine sampl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0632-z

    authors: Otukesh H,Chalian M,Hoseini R,Chalian H,Hooman N,Bedayat A,Yazdi RS,Sabaghi S,Mahdavi S

    更新日期:2007-12-01 00:00:00

  • Mortality in children with juvenile dermatomyositis: two decades of experience from a single tertiary care centre in North India.

    abstract::Survival and outcomes have improved considerably among patients with juvenile dermatomyositis (JDM) in the west. However, mortality continues to be high in the developing world. There is paucity of literature on this aspect of JDM from developing countries. We reviewed case files of all patients with JDM registered in...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2747-3

    authors: Singh S,Suri D,Aulakh R,Gupta A,Rawat A,Kumar RM

    更新日期:2014-11-01 00:00:00

  • Lack of association of vitamin D receptor gene polymorphisms/haplotypes in Sjögren's syndrome.

    abstract::The vitamin D is involved in a wide variety of biological processes including bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation. Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR). A series of common single-nucleotide polymorphisms...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-014-2639-6

    authors: Zilahi E,Chen JQ,Papp G,Szántó A,Zeher M

    更新日期:2015-02-01 00:00:00

  • Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor.

    abstract::We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3902-4

    authors: Moon JS,Lee DD,Park YB,Lee SW

    更新日期:2018-10-01 00:00:00