Abstract:
:The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis factor-alpha (TNFα) inhibitors and to compare with levels in healthy subjects. Biomarkers were measured in an observational cohort of 49 SpA patients (ankylosing spondylitis, n=32, and psoriatic arthritis, n=17) initiating TNFα inhibitor therapy (infliximab, n=38; etanercept, n=8; and adalimumab, n=3) and compared with levels in healthy subjects. Clinical parameters and biomarkers were measured at baseline, weeks 2, 6, and every 6-12 weeks for up to 3 years. Patients with co-morbidities (n=4), missing baseline samples (n=3), and adverse events (n=5) were excluded. Patients with SpA had compared with healthy subjects elevated IL-6 (median 8.5 ng/l (range, 0.98-64) vs. 1.3 (0.33-26)), VEGF (105 ng/l (22-752) vs. 45 (12-351)), YKL-40 (74 μg/l (14-572) vs. 43 (20-184)), and MMP-3 (43 μg/l (9.1-401) vs. 16 (2.5-47), p≤0.001), whereas total aggrecan was lower (662 μg/l (223-2,219) vs. 816 (399-2,190), p≤0.001). Two weeks after first treatment, all biomarker levels changed towards normal levels (p≤0.03) in clinical responders (n=24), and persistent reductions over 3 years were found in IL-6, VEGF, YKL-40, and MMP-3. Only MMP-3 decreased (p≤0.02) in non-responders (n=13). The study demonstrated changes of plasma IL-6, VEGF, YKL-40, MMP-3, and total aggrecan and a potential value for monitoring disease activity and treatment response in SpA patients. Larger prospective studies are required to clarify clinical utility of these biomarkers.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Pedersen SJ,Hetland ML,Sørensen IJ,Ostergaard M,Nielsen HJ,Johansen JSdoi
10.1007/s10067-010-1528-xsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
1301-9issue
11eissn
0770-3198issn
1434-9949journal_volume
29pub_type
杂志文章abstract::Renal involvement in systemic lupus erythematosus (SLE) is common and has been associated with an increased risk of mortality [1]. Early diagnosis is imperative to control proteinuria and prevent the progression to end-stage renal disease. Standard induction therapies include cyclophosphamide (CYC) and mycophenolate m...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-016-3511-7
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of steroid injection (local treatment, LT) into the digital flexor tendon sheath of dactylitis in psoriatic arthritis (PsA) patients as compared with systemic treatment (ST). METHODS:Forty-six PsA patients with a total of 73 dactylitic fingers were assessed in an observational, mu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05142-z
更新日期:2020-11-01 00:00:00
abstract::A 62-year-old man who suffered from severe deforming arthritis, secondary to chronic tophaceous gout with multilobular, solid, tender, enlarged subcutaneous nodules, and draining tophi in right second finger, was treated by free flap and finally got the more functional and aesthetic result. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1321-x
更新日期:2010-03-01 00:00:00
abstract::The involvement of brain-derived neurotrophic factor (BDNF) in rheumatoid arthritis (RA) is largely unknown. The distribution of BDNF and its associated receptors, TrkB and p75, in the synovial tissue of patients with RA was examined and contrasted with that in patients with osteoarthritis (OA). Additionally, levels o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0910-4
更新日期:2008-10-01 00:00:00
abstract::Juvenile idiopathic arthritis (JIA) is the most common chronic arthritis of childhood. Currently, it is characterized by seven categories. The enthesitis-related arthritis (ERA) category usually affects boys older than 6 years and presents with lower limb asymmetrical arthritis associated with enthesitis. Later, these...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-3029-4
更新日期:2015-11-01 00:00:00
abstract::Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain and systemic symptoms. The aetiology and pathogenesis of fibromyalgia are not yet fully understood. Blood neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammatory response. Platelet distribution width (PDW) and mean platelet volume (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3647-0
更新日期:2017-08-01 00:00:00
abstract::Determine the effect of daily low divided or single daily dose of prednisone on the longitudinal change in the number of tender and swollen joints and HAQ scores in African Americans (AA) with early rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-017-3943-8
更新日期:2018-02-01 00:00:00
abstract::The aim of this study was to determine the emotional and sociodemographic characteristics of patients with ankylosing spondylitis (AS) and to investigate the impact of the disease on their social life and quality of life (QOL). This study included 101 patients with the diagnosis of AS. All patients filled in a questio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-1150-5
更新日期:2006-03-01 00:00:00
abstract::Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diag...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-1074-y
更新日期:2009-04-01 00:00:00
abstract::An insufficiency fracture (IF) involving the acetabulum is presented. This fracture occurred in a 67-year-old woman who had been hysterectomized and oophorectomized 27 years earlier for a carcinoma of the uterine cervix, and who had received external pelvic irradiation. This IF location has been rarely described earli...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207215
更新日期:1992-09-01 00:00:00
abstract::Hyperimmunoglobulinemia D syndrome (HIDS) is newly recognized and resembles familial Mediterranean fever (FMF). It is inherited as an autosomal recessive trait. Mutation of the gene coding for mevalonate kinase is responsible for the disease. The gene is located at chromosome 12q24. The patients initially described we...
journal_title:Clinical rheumatology
pub_type: 信件
doi:10.1007/s10067-004-0953-0
更新日期:2005-02-01 00:00:00
abstract::Circulating intercellular adhesion molecule-1 (ICAM-1) and 3 types of autoantibodies were measured in 30 patients with angiographical or pathological proved vasculitis. There were 18 patients with systemic vasculitis and 12 patients with cutaneous vasculitis. The measured antibodies included anti-endothelial cell anti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231583
更新日期:1993-09-01 00:00:00
abstract::The antichromatin antibody (aCT) has been described as a useful marker for lupus nephropathy. The relevance of its nephritogenic potential may be appropriately evaluated in the context of renal histopathology. Therefore, the present study investigated the relationship of aCT with a particular histopathologic class of ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0939-4
更新日期:2008-11-01 00:00:00
abstract::A case of polymyositis associated with scleroderma, adult coeliac disease, diabetes mellitus and IgA nephropathy is reported in a 33-year-old male. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031278
更新日期:1984-12-01 00:00:00
abstract::Juvenile systemic lupus erythematosus is a rare multisystemic autoimmune disease with variable clinical manifestations, and disease onset before 16 years of age. Patients younger than 5 years are rarely affected and the age of onset may contribute to the course of disease in terms of clinical presentation, organ invol...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1576-2
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVES:To explore the link between ultrasonographic features of dactylitis in psoriatic arthritis (PsA) and symptoms, digital tenderness and duration of dactylitis. METHODS:Forty-eight cases of PsA dactylitis were investigated using high frequency ultrasound (US) both in grey scale (GS) and Power Doppler (PD), eva...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4400-z
更新日期:2019-03-01 00:00:00
abstract::The objective of this study was to describe ultrasonography (US) and magnetic resonance imaging (MRI) findings at painful Achilles tendons and entheses in patients with and without spondyloarthropathy (SpA and non-SpA) and healthy control persons (CTRLs). Particularly, we aimed to investigate if any changes differenti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2111-4
更新日期:2013-03-01 00:00:00
abstract::Expectancies play a major role for the treatment outcome of a broad variety of immune-mediated conditions and may strengthen or mimic the effects of regular long-term therapies. This study adds to a recently published study of Kox et al. (PNAS 111:7379-7384, 2014) on the ability to voluntarily influence the physiologi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-015-3009-8
更新日期:2016-04-01 00:00:00
abstract::A 22-year-old African male with known sickle cell anaemia was referred by a Congolese medical centre with a request to improve his poor physical condition. He was unable to walk, stand or sit because his large joints and his spine were either ankylosed or very rigid. Radiographs showed joint fusion from the third to t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670070047
更新日期:2000-01-01 00:00:00
abstract::This study aimed to investigate the multiple values of 18F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by 18F-FDG PET/CT and eventu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3794-3
更新日期:2017-10-01 00:00:00
abstract::A 61-year-old female with a history of vaginal dryness, Raynaud's phenomenon, xerostomia and xerophthalmia presented with exertional dyspnoea and weakness. Laboratory and instrumental examinations enabled us to make the diagnosis of primary Sjögren's syndrome, while cardiologic and imaging investigations evidenced iso...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-004-1071-8
更新日期:2005-08-01 00:00:00
abstract::The "A disintegrin and metalloprotease" (ADAM) family is thought to play an important role in tissue destruction and inflammatory reactions. ADAM-17 was first described as the protease responsible for tumor necrosis factor (TNF)-α shedding. Here, we have shown the expression of ADAM-17 in inflammatory myopathy and dem...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4014-5
更新日期:2018-04-01 00:00:00
abstract::A case of pseudo-pseudohypoparathyroidism (PPH) with shortening of the left femur and tibia and coalition of the base of the fourth metacarpals with capitatum and hamatum in bilateral wrist joints was presented. Involvement of the fourth digits both in hands and feet were more prominent on the left side, with shorteni...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0279-1
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:This study was conducted to assess the safety and efficacy of intra-articular injection of etanercept and compare it with corticosteroid injection in rheumatoid arthritis (RA) patients. METHODS:Fifty patients with RA who suffered from activity in one joint were randomized into two groups, received an intra-...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05235-9
更新日期:2021-02-01 00:00:00
abstract::Weekly adalimumab dosing is used to treat juvenile idiopathic arthritis (JIA), uveitis, and other pediatric rheumatic diseases, but the safety of such dosing has not previously been studied. A retrospective chart review was conducted to assess the safety of weekly adalimumab. Demographic and clinical data were collect...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3890-4
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To explore the trends in diagnosis of Kawasaki disease (KD) and determine the characteristics for patients outside the usual age range of 6 months to 4 years. METHOD:A retrospective review of patients with KD identified in four epidemiological surveys spanning 20 years (1998-2017) in Shanghai was performed. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05361-4
更新日期:2020-08-26 00:00:00
abstract::Pulse therapy is one of the most well-known methods used in the treatment of juvenile rheumatoid arthritis. This study assessed the outcome of methylprednisolone pulse therapy, its rate of efficacy, and its associated complications in patients with juvenile rheumatoid arthritis (JRA). This cross-sectional study was pe...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0919-8
更新日期:2008-11-01 00:00:00
abstract::The aim of the study was to investigate the long-term outcome of non-specific seronegative oligoarthritis in adults. The study included 64 adult patients with recent (<6 months) seronegative oligoarthritis (rheumatoid factor negative, number of swollen joints 1-4 during the first 6 months). Follow-up examinations were...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200096
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To assess whether systemic sclerosis (SSc) is associated with total knee arthroplasty (TKA) outcomes. METHODS:We used the 1998-2014 US National Inpatient Sample. We conducted multivariable-adjusted logistic regression analyses to examine the association of a diagnosis of SSc with post-TKA in-hospital complic...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04754-4
更新日期:2020-01-01 00:00:00
abstract::In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of met...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208347
更新日期:1995-05-01 00:00:00