Abstract:
OBJECTIVE:To determine clinical course and outcomes in rheumatic disease patients with coronavirus disease 2019 (COVID-19) and compare results to uninfected patients. METHODS:We conducted a case cohort study of autoimmune disease patients with COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR) from February 1, 2020, to July 31, 2020, and compared them in a 1:3 ratio with uninfected patients who were matched based on race, age, sex, and comorbidity index. Patient demographics, clinical course, and outcomes were compared among these patient groups. RESULTS:A total of 70 rheumatic disease patients with COVID-19 (mean age, 56.6 years; 64% African American) were identified. The 34 (49%) patients who were hospitalized used oral glucocorticoids more frequently than those treated as outpatients (p < 0.01). All 10 patients using anti-TNFα medications were treated as outpatients (p < 0.01). Those hospitalized with COVID-19 more often required ICU admission (17 (50%) vs 27 (26%), p = 0.01) and intubation (10 (29%) vs 6 (6%), p < 0.01) than uninfected patients and had higher mortality rates (6 (18%) vs 3 (3%), p < 0.01). Of the six COVID-19 patients who died, only one was of African ancestry (p = 0.03). CONCLUSION:Rheumatic disease patients infected with COVID-19 were more likely to require ICU admission, ventilation, and died more frequently versus uninfected patients with autoimmune disease. Patients on anti-TNFα medications were hospitalized less frequently, while those on chronic glucocorticoids were hospitalized more frequently. These findings have important implications for medication choice in rheumatic disease patients during the ongoing spread of COVID-19. Key Points • We show that hospitalized rheumatic disease patients with COVID-19 have poorer outcomes including ICU admission, ventilation, and death compared to hospitalized rheumatic disease patients not infected with COVID-19. • This study adds further support regarding protective effects of anti-TNFα medications in COVID-19 disease course, with 0 of 10 of these patients required hospitalization.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Arleo T,Tong D,Shabto J,O'Keefe G,Khosroshahi Adoi
10.1007/s10067-021-05578-xsubject
Has Abstractpub_date
2021-01-09 00:00:00eissn
0770-3198issn
1434-9949pii
10.1007/s10067-021-05578-xpub_type
杂志文章abstract::To analyze fucosylation of alpha(1)-acid glycoprotein (AGP) and to identify relations between AGP fucosylation and clinical and biochemical indices of disease activity in patients with rheumatoid arthritis (RA) treated with monoclonal antitumor necrosis factor (TNF) antibody infliximab, we examined 22 patients with RA...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0572-7
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The association between pyoderma gangrenosum (PG) and rheumatoid arthritis (RA) was not investigated in the setting of controlled studies. The risk of PG among patients with RA is not established. OBJECTIVE:The study aims to evaluate the magnitude of the association between RA and the subsequent development...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05253-7
更新日期:2021-02-01 00:00:00
abstract::Employing a recently developed questionnaire we studied the self-esteem structure of 61 female fibromyalgia (FM) patients by comparing them with i) 40 healthy psychology students and ii) 37 patients suffering from rheumatoid arthritis. Depressed FM patients (n=36) had a high need to gain self-esteem through competence...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02247798
更新日期:1997-11-01 00:00:00
abstract::The role of opioid therapy in chronic musculoskeletal disease continues to be controversial. However, recent years have seen a gradual shift towards the use of opioid therapy in chronic non-malignant pain (CNMP) following recognition that at least a subpopulation of such patients appears to benefit from long-term opio...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s100670200029
更新日期:2002-02-01 00:00:00
abstract::A 22-year-old African male with known sickle cell anaemia was referred by a Congolese medical centre with a request to improve his poor physical condition. He was unable to walk, stand or sit because his large joints and his spine were either ankylosed or very rigid. Radiographs showed joint fusion from the third to t...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670070047
更新日期:2000-01-01 00:00:00
abstract::To present the clinical and pathological findings in patients presenting with myositis caused by syphilis. The literature is reviewed, and pathophysiologic factors discussed. A 49-year-old Caucasian heterosexual male with a known history of stable human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection, ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1668-z
更新日期:2011-05-01 00:00:00
abstract::We encountered an adult patient with acute parvovirus B19 infection who presented with transient lupus-like symptoms (i.e., polyarthritis, fever, myalgia, pancytopenia, hypocomplementemia, and nephritis). Our case is characterized by the demonstration of acute nephritis as a complication of this infection, making it d...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0691-1
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Antineutrophil cytoplasmic antibodies (ANCAs) are considered a risk factor for granulomatosis with polyangiitis (GPA) exacerbation, especially when staphylococcal superantigens (SAgs) are present in nasal swabs. Their role in monitoring disease activity remains controversial. This study determined the relatio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04693-0
更新日期:2019-11-01 00:00:00
abstract::Interstitial lung disease (ILD) is a severe rheumatoid arthritis (RA) manifestation. The worst survival has been associated with usual interstitial pneumonia (UIP) definitive pattern in high-resolution chest tomography (HRCT) scans. Moreover, the use of methotrexate in RA-ILD is controversial. Our aim was to evaluate ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3707-5
更新日期:2017-07-01 00:00:00
abstract::Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02284051
更新日期:1988-03-01 00:00:00
abstract::Mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. It is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. This is the first report of septic arthritis with this fungus in a healthy Canadian male. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1448-9
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To explore the trends in diagnosis of Kawasaki disease (KD) and determine the characteristics for patients outside the usual age range of 6 months to 4 years. METHOD:A retrospective review of patients with KD identified in four epidemiological surveys spanning 20 years (1998-2017) in Shanghai was performed. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05361-4
更新日期:2020-08-26 00:00:00
abstract::Electrocardiographic (ECG) and echocardiographic examinations and 24-h ECG Holter monitoring were carried out in 100 patients (age < 65 years) with rheumatoid arthritis (RA) of stages II-IV according to Steinbrocker's criteria. One hundred patients with osteoarthrosis, spondyloarthrosis and painful shoulder matched fo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01450894
更新日期:1998-01-01 00:00:00
abstract::The objective of this study was to understand the patient experience of musculoskeletal imaging tests for investigation of inflammatory arthritis and factors that contribute to this experience. We conducted a thematic analysis of semi-structured interviews with 33 patients who had a recent peripheral joint musculoskel...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3760-0
更新日期:2018-08-01 00:00:00
abstract::Hyperuricemia is not only a risk factor for gout but also an independent determinant of hypertension, diabetes, and chronic kidney diseases. Although the incidence of gout in Korean adults is increasing, epidemiologic studies on hyperuricemia in the general Korean population are limited. Thus, this study aimed at eval...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4130-2
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. METHODS:A total of 497 AAV patients were retrosp...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-04975-y
更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:The primary objective was to evaluate the impact of an in-department pharmacist on the prevention of drug iatrogenesis in a rheumatology department. Secondary objectives were to determine (i) if medication history discrepancies were detected more frequently in the elderly or not, and (ii) if the...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05138-9
更新日期:2021-01-01 00:00:00
abstract::If rheumatoid arthritis (RA) patients with a mild disease course could be identified early in the phase of the disease, therapy with less aggressive and probably less toxic antirheumatic drugs seems to be rational. The aim of this study was to investigate which factors at baseline could predict a clinical response (Am...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s100670050121
更新日期:1999-01-01 00:00:00
abstract::To date, there have been very few studies on the age dependence of maximal isometric muscle strength (MIMS) in healthy subjects aged 20-80 years, based upon measurements of a large number of functional muscle groups (FMGs). Using a hand-held pull gauge it is possible to measure MIMS of nearly every FMG. The objectives...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050026
更新日期:2000-01-01 00:00:00
abstract::The study aims to comprehensively assess the profiles of myositis-specific autoantibodies (MSAs) in Chinese patients with polymyositis (PM)/dermatomyositis (DM) and compare them with a Japanese cohort. One hundred forty-five Chinese patients (68 classic DM, 25 clinically amyopathic DM [CADM], and 52 PM) and 165 Japane...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-2935-9
更新日期:2015-09-01 00:00:00
abstract::Identification of patients with exposure to viral hepatitis is an important part of the care of patients with inflammatory arthritis. This study was conducted to assess the extent of hepatitis B and C screening, and the prevalence of viral hepatitis in a cohort of patients with established rheumatoid arthritis (RA). T...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2612-4
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04802-z
更新日期:2020-02-01 00:00:00
abstract::Weekly adalimumab dosing is used to treat juvenile idiopathic arthritis (JIA), uveitis, and other pediatric rheumatic diseases, but the safety of such dosing has not previously been studied. A retrospective chart review was conducted to assess the safety of weekly adalimumab. Demographic and clinical data were collect...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3890-4
更新日期:2018-02-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure. At autopsy, there w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1395-5
更新日期:2010-07-01 00:00:00
abstract::The aim of this systematic review was to determine the potential role of dual-energy CT in the diagnosis and follow-up of gout with regard to the Outcome Measures in Rheumatology (OMERACT) filter. A systematic analysis of the literature was conducted using the MEDLINE and Cochrane databases and published abstracts of ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-017-3976-z
更新日期:2018-03-01 00:00:00
abstract::This study aimed to investigate the multiple values of 18F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by 18F-FDG PET/CT and eventu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3794-3
更新日期:2017-10-01 00:00:00
abstract::In this scoping review, we sought to summarize the types of outcomes collected in pregnant patients with ankylosing spondylitis (AS), and to identify some methodological limitations related to pregnancy research in these patients. A comprehensive search was done to identify relevant articles in MEDLINE and Embase. We ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-021-05588-9
更新日期:2021-01-19 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing joint damage and significant functional impairment. Methotrexate (MTX) remains the mainstay for the treatment of RA. MTX inhibits several enzymes of the folate and nucleotide pathways. Thymidylate synthase (TYMS) is an important enzyme in the d...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3608-7
更新日期:2017-06-01 00:00:00
abstract::A patient presenting with interstitial lung disease was predicted to have underlying polymyositis when found to be anti-Jo-1 antibody positive. When myopathy developed later with elevated serum creatine phosphokinase and myoglobin levels, the electromyogram was nonmyopathic, and polymyositis was confirmed by muscle bi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02201038
更新日期:1987-06-01 00:00:00
abstract::The level of the N terminal fragment of procollagen III (P3NP) levels of 100 consecutive patients affected by rheumatoid arthritis (RA) were evaluated in comparison with disease activity markers (erythrocytes sedimentation rate, C reactive protein), immunological status (rheumatoid factors, immune complexes) and joint...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02283106
更新日期:1992-12-01 00:00:00