Abstract:
:A number of cross-sectional analysis studies have been conducted to determine the relationships between serum uric acid and related variables or clinical manifestations. However, few data related to changes in serum uric acid within the same cohort population at two separate periods of time have been reported. In this study, we investigated the changes in serum uric acid in a population from baseline to 1-year follow-up and examined the associations with related parameters and medical conditions. A total of 1,437 eligible male subjects who underwent 2 medical examinations at a health promotion center at an interval of approximately 12 months were enrolled in this study. Data were obtained from routine physical assessments such as blood pressure, height, waist circumference, blood analyses for liver function, renal function, lipid profile, and electrolytes, along with standardized questionnaires including self-reported data. In this population, serum uric acid was significantly increased at 1-year follow-up compared with the baseline level (5.94 +/- 1.20 vs 5.99 +/- 1.22, p = 0.003). Changes of some confounders such as total bilirubin, creatinine, BUN, phosphorus, total cholesterol, and triglyceride were significantly associated with changes in serum uric acid. Among them, serum creatinine may be the most influential in determining the serum uric acid level (odds ratio = 21.691, 95%CI = 5.110-92.086). A change of serum uric acid over 1 year did not seem to affect changes in the clinical status for some medical conditions including hypertension, diabetes mellitus, cardiovascular disease, and metabolic syndrome. This analysis showed that a change in serum creatinine level between baseline and 1-year follow-up might be the most potent factor affecting a change in serum uric acid in healthy, male subjects. Changes of serum uric acid did not show any meaningful impact on the development of hypertension, heart failure, diabetes mellitus, and metabolic syndrome in this 1-year follow-up study.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Choe JY,Park SH,Kim JY,Shin IH,Kim SKdoi
10.1007/s10067-007-0732-9subject
Has Abstractpub_date
2008-04-01 00:00:00pages
483-9issue
4eissn
0770-3198issn
1434-9949journal_volume
27pub_type
杂志文章abstract::The aim of this study was to investigate the involvement of autonomic nervous system (ANS) function by using power spectral analysis of heart rate variability (HRV) method in patients with ankylosing spondylitis (AS). The study included 94 AS patients all fulfilling the New York criteria for AS, and 49 healthy volunte...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/pl00011198
更新日期:2001-01-01 00:00:00
abstract::Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-on...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04470-z
更新日期:2019-05-01 00:00:00
abstract::Circulating intercellular adhesion molecule-1 (ICAM-1) and 3 types of autoantibodies were measured in 30 patients with angiographical or pathological proved vasculitis. There were 18 patients with systemic vasculitis and 12 patients with cutaneous vasculitis. The measured antibodies included anti-endothelial cell anti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231583
更新日期:1993-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031611
更新日期:1985-09-01 00:00:00
abstract::As a class, tumor necrosis factor (TNF)-alpha inhibitors have provided clinicians significant control over chronic inflammatory diseases. With their widespread use has come the emergence of new side effects such as the reactivation of latent infections. One such infection that may reactivate is the hepatitis B virus (...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2010-09-01 00:00:00
abstract::The goals of this study were to determine if secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis (RA) compared to control subjects and to examine the relationships of S-SMase activity with functional status, quality of life, and RA disease activity measurements. We collected...
journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The association between pyoderma gangrenosum (PG) and rheumatoid arthritis (RA) was not investigated in the setting of controlled studies. The risk of PG among patients with RA is not established. OBJECTIVE:The study aims to evaluate the magnitude of the association between RA and the subsequent development...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05253-7
更新日期:2021-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3699-1
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To evaluate and compare the diagnostic test accuracy of magnetic resonance imaging (MRI) and ultrasound (US) for bone erosion in rheumatoid arthritis (RA) patients for a specific and efficient diagnostic recommendation. METHOD:To evaluate the diagnostic accuracy, the sensitivity, specificity, area under the ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10067-019-04825-6
更新日期:2020-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2387-z
更新日期:2014-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s100670200029
更新日期:2002-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3937-6
更新日期:2018-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1639-4
更新日期:2011-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208035
更新日期:1991-03-01 00:00:00
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journal_title:Clinical rheumatology
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更新日期:2020-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02242463
更新日期:1997-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0703-8
更新日期:2003-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1325-6
更新日期:2010-03-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02201028
更新日期:1987-06-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Alkaptonuria (AKU) is a rare metabolic disease. The global incidence is 1:100,000 to 1:250,000. However, identification of a founder mutation in a gypsy population from India prompted us to study the prevalence of AKU in this population and to do molecular typing in referred cases of AKU from the rest of I...
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doi:10.1007/s10067-020-05020-8
更新日期:2020-09-01 00:00:00
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更新日期:2012-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1530-3
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3536-y
更新日期:2017-04-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1139-6
更新日期:2009-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:1992-03-01 00:00:00